Výsledky vyhledávání - "Xavier, Brazzolotto"

Akademický článek

8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases

Publikováno v: Acta Pharmaceutica Sinica B, Vol 13, Iss 5, Pp 2152-2175 (2023)

We describe the development of quinolylnitrones (QNs) as multifunctional ligands inhibiting cholinesterases (ChEs: acetylcholinesterase and butyrylcholinesterase–hBChE) and monoamine oxidases (hMAO-A/B) for the therapy of neurodegenerative diseases

Externí odkaz: https://doaj.org/article/7f16c8ed45a64b12942b299889a26612

Zobrazit plný text záznamu

Akademický článek

Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes

Autor: Stane Pajk, Damijan Knez, Urban Košak, Maja Zorović, Xavier Brazzolotto, Nicolas Coquelle, Florian Nachon, Jacques-Philippe Colletier, Marko Živin, Jure Stojan, Stanislav Gobec

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 498-505 (2020)

Brain butyrylcholinesterase (BChE) is an attractive target for drugs designed for the treatment of Alzheimer’s disease (AD) in its advanced stages. It also potentially represents a biomarker for progression of this disease. Based on the crystal str

Externí odkaz: https://doaj.org/article/dbf12d5fe8ba43da9d6b77ed1a105af9

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Diisopropylfluorophosphate-induced status epilepticus drives complex glial cell phenotypes in adult male mice

Autor: Clémence Maupu, Julie Enderlin, Alexandre Igert, Myriam Oger, Stéphane Auvin, Rahma Hassan-Abdi, Nadia Soussi-Yanicostas, Xavier Brazzolotto, Florian Nachon, Grégory Dal Bo, Nina Dupuis

Publikováno v: Neurobiology of Disease, Vol 152, Iss , Pp 105276- (2021)

Organophosphate pesticides and nerve agents (OPs), are characterized by cholinesterase inhibition. In addition to severe peripheral symptoms, high doses of OPs can lead to seizures and status epilepticus (SE). Long lasting seizure activity and subseq

Externí odkaz: https://doaj.org/article/a2925ef027ff413ab4ff53a35214c3ee

Zobrazit plný text záznamu

Akademický článek

Fine-Tuning the Biological Profile of Multitarget Mitochondriotropic Antioxidants for Neurodegenerative Diseases

Autor: Daniel Chavarria, Ophelie Da Silva, Sofia Benfeito, Sandra Barreiro, Jorge Garrido, Fernando Cagide, Pedro Soares, Fernando Remião, Xavier Brazzolotto, Florian Nachon, Paulo J. Oliveira, José Dias, Fernanda Borges

Publikováno v: Antioxidants, Vol 10, Iss 2, p 329 (2021)

Neurotransmitter depletion and mitochondrial dysfunction are among the multiple pathological events that lead to neurodegeneration. Following our previous studies related with the development of multitarget mitochondriotropic antioxidants, this study

Externí odkaz: https://doaj.org/article/7e4c8f8ec8cb43e691f140757bac9eea

Zobrazit plný text záznamu

Akademický článek

A Thermophilic Bacterial Esterase for Scavenging Nerve Agents: A Kinetic, Biophysical and Structural Study

Autor: Janek Bzdrenga, Elodie Trenet, Fabien Chantegreil, Kevin Bernal, Florian Nachon, Xavier Brazzolotto

Publikováno v: Molecules, Vol 26, Iss 3, p 657 (2021)

Organophosphorous nerve agents (OPNA) pose an actual and major threat for both military and civilians alike, as an upsurge in their use has been observed in the recent years. Currently available treatments mitigate the effect of the nerve agents, and

Externí odkaz: https://doaj.org/article/f03d1fc962ef4603b1acd1aee3be968e

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime

Autor: André-Guilhem Calas, Anne-Sophie Hanak, Nina Jaffré, Aurélie Nervo, José Dias, Catherine Rousseau, Charlotte Courageux, Xavier Brazzolotto, Pascal Villa, Adeline Obrecht, Jean-François Goossens, Christophe Landry, Johan Hachani, Fabien Gosselet, Marie-Pierre Dehouck, Jagadeesh Yerri, Maria Kliachyna, Rachid Baati, Florian Nachon

Publikováno v: Biomolecules, Vol 10, Iss 6, p 858 (2020)

(1) Background: Human exposure to organophosphorus compounds employed as pesticides or as chemical warfare agents induces deleterious effects due to cholinesterase inhibition. One therapeutic approach is the reactivation of inhibited acetylcholineste

Externí odkaz: https://doaj.org/article/c8ad1bdb8ca0419e90bec0584f145514

Zobrazit plný text záznamu

Plný text ve formátu HTML

Pseudo-irreversible butyrylcholinesterase inhibitors: Structure-activity relationships, computational and crystallographic study of the N-dialkyl O-arylcarbamate warhead

Autor: Anže Meden, Damijan Knez, Xavier Brazzolotto, Fabrice Modeste, Andrej Perdih, Anja Pišlar, Maša Zorman, Maja Zorović, Milica Denic, Stane Pajk, Marko Živin, Florian Nachon, Stanislav Gobec

Publikováno v: European journal of medicinal chemistry. 247

Alongside reversible butyrylcholinesterase inhibitors, a plethora of covalent butyrylcholinesterase inhibitors have been reported in the literature, typically pseudo-irreversible carbamates. For these latter, however, most cases lack full confirmatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d593c4357e4e1d752379a2c2350596d0
https://pubmed.ncbi.nlm.nih.gov/36586299

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání