Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Xander H. T. Wehrens"'
Autor:
Zain Dardas, Jawid M. Fatih, Angad Jolly, Moez Dawood, Haowei Du, Christopher M. Grochowski, Edward G. Jones, Shalini N. Jhangiani, Xander H. T. Wehrens, Pengfei Liu, Weimin Bi, Eric Boerwinkle, Jennifer E. Posey, Donna M. Muzny, Richard A. Gibbs, James R. Lupski, Zeynep Coban-Akdemir, Shaine A. Morris
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-20 (2024)
Abstract Background NODAL signaling plays a critical role in embryonic patterning and heart development in vertebrates. Genetic variants resulting in perturbations of the TGF-β/NODAL signaling pathway have reproducibly been shown to cause laterality
Externí odkaz:
https://doaj.org/article/732bd51decf14dba8374c1b62dec21e8
Autor:
Chang Seok Lee, Sung Yun Jung, Rachel Sue Zhen Yee, Nadia H. Agha, Jin Hong, Ting Chang, Lyle W. Babcock, Jorie D. Fleischman, Benjamin Clayton, Amy D. Hanna, Christopher S. Ward, Denise Lanza, Ayrea E. Hurley, Pumin Zhang, Xander H. T. Wehrens, William R. Lagor, George G. Rodney, Susan L. Hamilton
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-19 (2023)
Abstract Here we show that striated muscle preferentially expressed protein kinase α (Spegα) maintains cardiac function in hearts with Spegβ deficiency. Speg is required for stability of excitation-contraction coupling (ECC) complexes and interact
Externí odkaz:
https://doaj.org/article/7a8ed53a9dd64509bc4efd890aaae296
Publikováno v:
Cells, Vol 12, Iss 10, p 1363 (2023)
This article reviews progress in the field of cardiac genome editing, in particular, its potential utility in treating cardiac arrhythmias. First, we discuss genome editing methods by which DNA can be disrupted, inserted, deleted, or corrected in car
Externí odkaz:
https://doaj.org/article/0c1f5a45ff7c47b4a46109070430b67f
Autor:
Pooja Patel, Arielys Mendoza, Dexter J. Robichaux, Meng C. Wang, Xander H. T. Wehrens, Jason Karch
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Mitochondrial permeability transition pore (MPTP)-dependent necrosis contributes to numerous pathologies in the heart, brain, and skeletal muscle. The MPTP is a non-selective pore in the inner mitochondrial membrane that is triggered by high levels o
Externí odkaz:
https://doaj.org/article/d0aa832a997846169e462d49c336ea7a
Autor:
David Y. Chiang, Satadru Lahiri, Guoliang Wang, Jason Karch, Meng C. Wang, Sung Y. Jung, Albert J. R. Heck, Arjen Scholten, Xander H. T. Wehrens
Publikováno v:
Proteomes, Vol 9, Iss 2, p 27 (2021)
Hyperphosphorylation of the calcium release channel/ryanodine receptor type 2 (RyR2) at serine 2814 (S2814) is associated with multiple cardiac diseases including atrial fibrillation and heart failure. Despite recent advances, the molecular mechanism
Externí odkaz:
https://doaj.org/article/693d54477023445b8fa93c2d7f62a0b7
Autor:
Cristina E. Molina, Issam H. Abu-Taha, Qiongling Wang, Elena Roselló-Díez, Marcus Kamler, Stanley Nattel, Ursula Ravens, Xander H. T. Wehrens, Leif Hove-Madsen, Jordi Heijman, Dobromir Dobrev
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Atrial fibrillation (AF) and heart failure (HF) are common cardiovascular diseases that often co-exist. Animal models have suggested complex AF-promoting atrial structural, electrical, and Ca2+-handling remodeling in the setting of HF, but data in hu
Externí odkaz:
https://doaj.org/article/1962b8dcc1f442a2a39a855142be13a1
Autor:
José A. Herrera, Christopher S. Ward, Meagan R. Pitcher, Alan K. Percy, Steven Skinner, Walter E. Kaufmann, Daniel G. Glaze, Xander H. T. Wehrens, Jeffrey L. Neul
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 4, Pp 363-371 (2015)
One quarter of deaths associated with Rett syndrome (RTT), an X-linked neurodevelopmental disorder, are sudden and unexpected. RTT is associated with prolonged QTc interval (LQT), and LQT-associated cardiac arrhythmias are a potential cause of unexpe
Externí odkaz:
https://doaj.org/article/ebf4109932af452a8babec28ce379258
Autor:
Melanie G. Kitagawa, Julia O. Reynolds, Xander H. T. Wehrens, Robert M. Bryan, Lavannya M. Pandit
Publikováno v:
Frontiers in Medicine, Vol 4 (2017)
IntroductionPulmonary hypertension (PH) carries significant associated morbidity and mortality and the underlying molecular mechanisms of PH are not well understood. Loss-of-function mutations in TASK-1 potassium channels are associated with PH in hu
Externí odkaz:
https://doaj.org/article/c9cc16ae7a3b474abab0a900f11a116a
Autor:
Eric Himelman, Julie Nouet, Mauricio A. Lillo, Alexander Chong, Delong Zhou, Xander H. T. Wehrens, George G. Rodney, Lai-Hua Xie, Natalia Shirokova, Jorge E. Contreras, Diego Fraidenraich
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 323:H983-H995
Dilated cardiomyopathy is the leading cause of death in Duchenne muscular dystrophy (DMD), an inherited degenerative disease of the cardiac and skeletal muscle caused by absence of the protein dystrophin. We showed one hallmark of DMD cardiomyopathy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a86255591c808805041d03090769303
https://doi.org/10.1152/ajpheart.00179.2022
https://doi.org/10.1152/ajpheart.00179.2022
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 324(1)
Space medicine is key to the human exploration of outer space and pushes the boundaries of science, technology, and medicine. Because of harsh environmental conditions related to microgravity and other factors and hazards in outer space, astronauts a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a73c1e8ea0ea7a4aac6308f898418bf7
https://pubmed.ncbi.nlm.nih.gov/36399385
https://pubmed.ncbi.nlm.nih.gov/36399385