Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Xabier, Guruceaga"'
Autor:
Adela Martin-Vicente, Ana Camila Oliveira Souza, Xabier Guruceaga, Harrison I. Thorn, Jinhong Xie, Ashley V. Nywening, Wenbo Ge, Jarrod R. Fortwendel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Fungal pathogens must exhibit strong nutritional plasticity, effectively sensing and utilizing diverse nutrients to support virulence. How the signals generated by nutritional sensing are efficiently translated to the morphogenetic machinery
Externí odkaz:
https://doaj.org/article/5a0472a7915f416c96e09e8fa6ce7d05
Autor:
Jinhong Xie, Jeffrey M. Rybak, Adela Martin-Vicente, Xabier Guruceaga, Harrison I. Thorn, Ashley V. Nywening, Wenbo Ge, Josie E. Parker, Steven L. Kelly, P. David Rogers, Jarrod R. Fortwendel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Triazoles, the most widely used class of antifungal drugs, inhibit the biosynthesis of ergosterol, a crucial component of the fungal plasma membrane. Inhibition of a separate ergosterol biosynthetic step, catalyzed by the sterol C-24 methylt
Externí odkaz:
https://doaj.org/article/5bf67aaf3a334a329c3a9686785bf735
Autor:
Jeffrey M. Rybak, Jinhong Xie, Adela Martin-Vicente, Xabier Guruceaga, Harrison I. Thorn, Ashley V. Nywening, Wenbo Ge, Ana C. O. Souza, Amol C. Shetty, Carrie McCracken, Vincent M. Bruno, Josie E. Parker, Steven L. Kelly, Hannah M. Snell, Christina A. Cuomo, P. David Rogers, Jarrod R. Fortwendel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Triazole antifungals function as ergosterol biosynthesis inhibitors and are frontline therapy for invasive fungal infections, such as invasive aspergillosis. The primary mechanism of action of triazoles is through the specific inhibition of
Externí odkaz:
https://doaj.org/article/f05294528fb640d8a22b184dae7ef4b2
Autor:
Harrison I. Thorn, Xabier Guruceaga, Adela Martin-Vicente, Ashley V. Nywening, Jinhong Xie, Wenbo Ge, Jarrod R. Fortwendel
Publikováno v:
mSphere, Vol 9, Iss 3 (2024)
ABSTRACTAspergillus fumigatus is a major invasive mold pathogen and the most frequent etiologic agent of invasive aspergillosis. The currently available treatments for invasive aspergillosis are limited in both number and efficacy. Our recent work ha
Externí odkaz:
https://doaj.org/article/7ddc1d00b17f49cdb51d639cab468426
Autor:
Xabier Guruceaga, Uxue Perez-Cuesta, Adela Martin-Vicente, Eduardo Pelegri-Martinez, Harrison I. Thorn, Saioa Cendon-Sanchez, Jinhong Xie, Ashley V. Nywening, Andoni Ramirez-Garcia, Jarrod R. Fortwendel, Aitor Rementeria
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
In this study, two distinct in vitro infection models of Aspergillus fumigatus, using murine macrophages (RAW264.7) and human lung epithelial cells (A549), were employed to identify the genes important for fungal adaptation during infection. Transcri
Externí odkaz:
https://doaj.org/article/ed608cd0adf649ad8318efe5f7449234
Autor:
Xabier Guruceaga, Guillermo Ezpeleta, Emilio Mayayo, Monica Sueiro-Olivares, Ana Abad-Diaz-De-Cerio, José Manuel Aguirre Urízar, Hong G. Liu, Philipp Wiemann, Jin Woo Bok, Scott G. Filler, Nancy P. Keller, Fernando L. Hernando, Andoni Ramirez-Garcia, Aitor Rementeria
Publikováno v:
Virulence, Vol 9, Iss 1, Pp 1548-1561 (2018)
Virulence mechanisms of the pathogenic fungus Aspergillus fumigatus are multifactorial and depend on the immune state of the host, but little is known about the fungal mechanism that develops during the process of lung invasion. In this study, microa
Externí odkaz:
https://doaj.org/article/2f401884faf044bb8f5ce754b968ea69
Autor:
Xabier Guruceaga, Uxue Perez-Cuesta, Aize Pellon, Saioa Cendon-Sanchez, Eduardo Pelegri-Martinez, Oskar Gonzalez, Fernando Luis Hernando, Emilio Mayayo, Juan Anguita, Rosa M. Alonso, Nancy P. Keller, Andoni Ramirez-Garcia, Aitor Rementeria
Publikováno v:
Journal of Fungi, Vol 7, Iss 11, p 936 (2021)
The activity of fumagillin, a mycotoxin produced by Aspergillus fumigatus, has not been studied in depth. In this study, we used a commercial fumagillin on cultures of two cell types (A549 pneumocytes and RAW 264.7 macrophages). This toxin joins its
Externí odkaz:
https://doaj.org/article/e06448526b3e4decb5db64303b6d2e08
Autor:
Uxue Perez-Cuesta, Xabier Guruceaga, Saioa Cendon-Sanchez, Eduardo Pelegri-Martinez, Fernando L. Hernando, Andoni Ramirez-Garcia, Ana Abad-Diaz-de-Cerio, Aitor Rementeria
Publikováno v:
Journal of Fungi, Vol 7, Iss 7, p 518 (2021)
Aspergillus fumigatus is a ubiquitous soil decomposer and an opportunistic pathogen that is characterized by its large metabolic machinery for acquiring nutrients from media. Lately, an ever-increasing number of genes involved in fungal nutrition has
Externí odkaz:
https://doaj.org/article/3b804d1385264595ad8b1895ec602abf
Autor:
Eduardo Pelegri-Martinez, Xabier Guruceaga, Leire Martin-Souto, Ana Abad-Diaz-de-Cerio, Aitor Rementeria, Alazne Dominguez-Monedero, Mikel Gallego, Oscar Martinez, Eunate Arana-Arri, Maitane Aranzamendi, Andoni Ramirez-Garcia
Publikováno v:
Journal of applied microbiologyREFERENCES. 133(6)
Introduction Quantitative reverse transcription PCR (RT-qPCR) is the leading tool to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Given that it will almost certainly continue to coexist with other respiratory viruses in the co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57dfc18ed551956b5ef927042240fe0a
https://pubmed.ncbi.nlm.nih.gov/35988051
https://pubmed.ncbi.nlm.nih.gov/35988051
Autor:
Ane Yaldebere, Oskar González, Xabier Guruceaga, Andoni Ramirez-Garcia, Aitor Rementeria, Rosa María Alonso
Publikováno v:
EKAIA Euskal Herriko Unibertsitateko Zientzia eta Teknologia Aldizkaria.
Aspergillus fumigatus onddoak sortutako aspergilosi inbaditzailea mehatxua da immunoeskasia duten gaixoentzat. Azkeneko ikerketa batzuen arabera, fumagilinak, onddoak sortutako mikotoxinak, gaixotasunaren hedapenarekin zerikusia duela ikusi da. Hori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30799e9d453888986a255634fac8430a
https://doi.org/10.1387/ekaia.23368
https://doi.org/10.1387/ekaia.23368