Zobrazeno 1 - 10
of 279
pro vyhledávání: '"Xabier, Agirre"'
Autor:
Francisco Exposito, Miriam Redrado, Diego Serrano, Silvia Calabuig-Fariñas, Aida Bao-Caamano, Sandra Gallach, Eloisa Jantus-Lewintre, Angel Diaz-Lagares, Aitor Rodriguez-Casanova, Juan Sandoval, Edurne San Jose-Eneriz, Javier Garcia, Esther Redin, Yaiza Senent, Sergio Leon, Ruben Pio, Rafael Lopez, Julen Oyarzabal, Antonio Pineda-Lucena, Xabier Agirre, Luis M. Montuenga, Felipe Prosper, Alfonso Calvo
Publikováno v:
Cell Death and Disease, Vol 15, Iss 11, Pp 1-16 (2024)
Abstract The treatment of non-small cell lung cancer (NSCLC) patients has significantly improved with recent therapeutic strategies; however, many patients still do not benefit from them. As a result, new treatment approaches are urgently needed. In
Externí odkaz:
https://doaj.org/article/6e85bcef9c6c4041a19b62d5fdc24ce3
Autor:
Luis V. Valcárcel, Edurne San José-Enériz, Raquel Ordoñez, Iñigo Apaolaza, Danel Olaverri-Mendizabal, Naroa Barrena, Ana Valcárcel, Leire Garate, Jesús San Miguel, Antonio Pineda-Lucena, Xabier Agirre, Felipe Prósper, Francisco J. Planes
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The development of computational tools for the systematic prediction of metabolic vulnerabilities of cancer cells constitutes a central question in systems biology. Here, we present gmctool, a freely accessible online tool that allows us to
Externí odkaz:
https://doaj.org/article/c4d4832b44504993870e80bfa11472fa
Autor:
Edurne San José-Enériz, Naroa Gimenez-Camino, Obdulia Rabal, Leire Garate, Estibaliz Miranda, Nahia Gómez-Echarte, Fernando García, Stella Charalampopoulou, Elena Sáez, Amaia Vilas-Zornoza, Patxi San Martín-Uriz, Luis V. Valcárcel, Naroa Barrena, Diego Alignani, Luis Esteban Tamariz-Amador, Ana Pérez-Ruiz, Sebastian Hilscher, Mike Schutkowski, Ana Alfonso-Pierola, Nicolás Martinez-Calle, María José Larrayoz, Bruno Paiva, María José Calasanz, Javier Muñoz, Marta Isasa, José Ignacio Martin-Subero, Antonio Pineda-Lucena, Julen Oyarzabal, Xabier Agirre, Felipe Prósper
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract Despite the development of novel therapies for acute myeloid leukemia, outcomes remain poor for most patients, and therapeutic improvements are an urgent unmet need. Although treatment regimens promoting differentiation have succeeded in the
Externí odkaz:
https://doaj.org/article/c19f4277205c445384d53303bce19ff2
Autor:
Lara Gil-Melgosa, Rafael Llombart-Blanco, Leire Extramiana, Isabel Lacave, Gloria Abizanda, Estibaliz Miranda, Xabier Agirre, Felipe Prósper, Antonio Pineda-Lucena, Juan Pons-Villanueva, Ana Pérez-Ruiz
Publikováno v:
Bone & Joint Research, Vol 13, Iss 4, Pp 169-183 (2024)
Aims: Rotator cuff (RC) injuries are characterized by tendon rupture, muscle atrophy, retraction, and fatty infiltration, which increase injury severity and jeopardize adequate tendon repair. Epigenetic drugs, such as histone deacetylase inhibitors (
Externí odkaz:
https://doaj.org/article/6f1a66f00d414accba4ab27fbadcc1c7
Autor:
Nahia Gómez-Echarte, Edurne San José-Enériz, Arantxa Carrasco-León, Naroa Barrena, Estibaliz Miranda, Leire Garate, Beatriz García-Torre, Sandra Alonso-Moreno, Naroa Gimenez-Camino, Estibaliz Urizar-Compains, Danel Olaverri-Mendizabal, Paula Aguirre-Ruiz, Beñat Ariceta, Luis-Esteban Tamariz-Amador, Paula Rodriguez-Otero, Francisco J. Planes, Laura Belver, José Ignacio Martín-Subero, Felipe Prosper, Xabier Agirre
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
Not available.
Externí odkaz:
https://doaj.org/article/d9ad4eb37a8149279d2b82a9df1dfc5d
Autor:
Sandra P. Nunes, Lucia Morales, Carolina Rubio, Ester Munera-Maravilla, Iris Lodewijk, Cristian Suárez-Cabrera, Victor G. Martínez, Mercedes Pérez-Escavy, Miriam Pérez-Crespo, Miguel Alonso Sánchez, Esther Montesinos, Edurne San José-Enériz, Xabier Agirre, Felipe Prósper, Antonio Pineda-Lucena, Rui Henrique, Marta Dueñas, Margareta P. Correia, Carmen Jerónimo, Jesús M. Paramio
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-15 (2024)
Abstract Alterations in the epigenetic machinery in both tumor and immune cells contribute to bladder cancer (BC) development, constituting a promising target as an alternative therapeutic option. Here, we have explored the effects of a novel histone
Externí odkaz:
https://doaj.org/article/2e7cebeed11f4705be37c46da8ae9498
Autor:
Alicja Zawiślak, Krzysztof Woźniak, Gianluca Tartaglia, Xabier Agirre, Satish Gupta, Beata Kawala, Anna Znamirowska-Bajowska, Katarzyna Grocholewicz, Felipe Prosper, Jan Lubiński, Anna Jakubowska
Publikováno v:
Diagnostics, Vol 14, Iss 14, p 1537 (2024)
Non-syndromic orofacial cleft (OFC) is the most common facial developmental defect in the global population. The etiology of these birth defects is complex and multifactorial, involving both genetic and environmental factors. This study aimed to dete
Externí odkaz:
https://doaj.org/article/22957d92f5cf474daf9546ac8f70557c
Autor:
Marta Moya-Jódar, Asier Ullate-Agote, Paula Barlabé, Juan Roberto Rodríguez-Madoz, Gloria Abizanda, Carolina Barreda, Xonia Carvajal-Vergara, Amaia Vilas-Zornoza, Juan Pablo Romero, Leire Garate, Xabier Agirre, Giulia Coppiello, Felipe Prósper, Xabier L. Aranguren
Publikováno v:
Stem Cell Reports, Vol 18, Iss 1, Pp 64-80 (2023)
Summary: Naive human pluripotent stem cells (hPSCs) are defined as the in vitro counterpart of the human preimplantation embryo’s epiblast and are used as a model system to study developmental processes. In this study, we report the discovery and c
Externí odkaz:
https://doaj.org/article/5525088ab778485bae0f0d5d92dd1f1f
Autor:
Sara Villar, Beñat Ariceta, Xabier Agirre, Aura Daniela Urribarri, Rosa Ayala, David Martínez-Cuadrón, Juan Miguel Bergua, Susana Vives, Lorenzo Algarra, Mar Tormo, Pilar Martínez, Josefina Serrano, Catia Simoes, Pilar Herrera, Maria José Calasanz, Ana Alfonso-Piérola, Bruno Paiva, Joaquín Martínez-López, Jesús F. San Miguel, Felipe Prósper, Pau Montesinos
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Acute myeloid leukemia (AML) in the elderly remains a clinical challenge, with a five-year overall survival rate below 10%. The current ELN 2017 genetic risk classification considers cytogenetic and mutational characteristics to stratify fit AML pati
Externí odkaz:
https://doaj.org/article/3518c66232c441da81dbca6328896425
Autor:
Marian Gimeno, Edurne San José-Enériz, Sara Villar, Xabier Agirre, Felipe Prosper, Angel Rubio, Fernando Carazo
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Artificial intelligence (AI) can unveil novel personalized treatments based on drug screening and whole-exome sequencing experiments (WES). However, the concept of “black box” in AI limits the potential of this approach to be translated into the
Externí odkaz:
https://doaj.org/article/91f44e62426944cb9d8b24cbc157b7d0