Zobrazeno 1 - 10
of 280
pro vyhledávání: '"XUEZHONG LIU"'
Autor:
Li Wang, Chaofan Zhang, Muhammad Azhar Memon, Qianting Shi, Le Lu, Xishuai Tong, Yonggang Ma, Hui Zou, Jianhong Gu, Xuezhong Liu, Jianchun Bian, Zongping Liu, Yan Yuan
Publikováno v:
Poultry Science, Vol 104, Iss 1, Pp 104597- (2025)
Cadmium (Cd) is an environmental pollutant that has neurotoxic properties, which poses serious threats to human health and the development of poultry farming. Chlorogenic acid (CGA) is a dietary polyphenol exhibit various biological activities such a
Externí odkaz:
https://doaj.org/article/79d44457d68c47d6b493968557a28a17
Autor:
Yong Tao, Veronica Lamas, Wan Du, Wenliang Zhu, Yiran Li, Madelynn N. Whittaker, John A. Zuris, David B. Thompson, Arun Prabhu Rameshbabu, Yilai Shu, Xue Gao, Johnny H. Hu, Charles Pei, Wei-Jia Kong, Xuezhong Liu, Hao Wu, Benjamin P. Kleinstiver, David R. Liu, Zheng-Yi Chen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Mutations in Atp2b2, an outer hair cell gene, cause dominant hearing loss in humans. Using a mouse model Atp2b2 Obl/+, with a dominant hearing loss mutation (Oblivion), we show that liposome-mediated in vivo delivery of CRISPR-Cas9 ribonucle
Externí odkaz:
https://doaj.org/article/a29936b8a683497cbbd1b953799336a4
Autor:
Xianlin Liu, Jie Wen, Xuezhong Liu, Anhai Chen, Sijun Li, Jing Liu, Jie Sun, Wei Gong, Xiaoming Kang, Zhili Feng, Chufeng He, Lingyun Mei, Jie Ling, Yong Feng
Publikováno v:
PLoS ONE, Vol 18, Iss 9, p e0288640 (2023)
The ELMOD3 gene is implicated in causing autosomal recessive/dominant non-syndromic hearing loss in humans. However, the etiology has yet to be completely elucidated. In this study, we generated a patient-derived iPSC line carrying ELMOD3 c.512A>G mu
Externí odkaz:
https://doaj.org/article/adce9d9495d24721b446265975dd91ca
Autor:
Wenhua Zhang, Mingchang Xu, Shuangquan Wen, Li Wang, Kanglei Zhang, Chaofan Zhang, Hui Zou, Jianhong Gu, Xuezhong Liu, Jianchun Bian, Zongping Liu, Yan Yuan
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 247, Iss , Pp 114239- (2022)
Cadmium (Cd) is a highly neurotoxic environmental pollutant. Puerarin (Pur) is a natural antioxidant isolated from Kudzu root that exhibits a powerful neuroprotective effect. Herein, we illustrated the mechanism underlying the protective effect of Pu
Externí odkaz:
https://doaj.org/article/11ba0c3811014152af1650634303296d
PINK1/Parkin-mediated mitophagy modulates cadmium-induced apoptosis in rat cerebral cortical neurons
Autor:
Shuangquan Wen, Li Wang, Chaofan Zhang, Ruilong Song, Hui Zou, Jianhong Gu, Xuezhong Liu, Jianchun Bian, Zongping Liu, Yan Yuan
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 244, Iss , Pp 114052- (2022)
Cadmium is a persistent environmental pollutant whose neurotoxicity is of serious concern. Mitochondrial dysfunction and its mediated mitophagy and apoptosis are considered key events in Cd-induced neurological pathologies, but the exact molecular me
Externí odkaz:
https://doaj.org/article/a42c01319692496aaa79491862ae9242
Autor:
Kevin Y. Zhan, Oliver F. Adunka, Adrien Eshraghi, William J. Riggs, Sandra M. Prentiss, Denise Yan, Fred F. Telischi, Xuezhong Liu, Shuman He
Publikováno v:
Journal of Otology, Vol 16, Iss 1, Pp 40-46 (2021)
Background: Congenital hearing loss is remarkably heterogeneous, with over 130 deafness genes and thousands of variants, making for innumerable genotype/phenotype combinations. Understanding both the pathophysiology of hearing loss and molecular site
Externí odkaz:
https://doaj.org/article/363bbb63585044e9963824ac42bdb64c
Autor:
Junzhao Yuan, Yumeng Zhao, Yuni Bai, Jianhong Gu, Yan Yuan, Xuezhong Liu, Zongping Liu, Hui Zou, Jianchun Bian
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 228, Iss , Pp 112993- (2021)
Acute exposure to cadmium (Cd) causes vacuolar degeneration in buffalo rat liver 3 A (BRL 3 A) cells. The present study aimed to determine the relationship between Cd-induced microtubule damage and intracellular vacuolar degeneration. Western blottin
Externí odkaz:
https://doaj.org/article/5ba97bc63167488a88aa4df8540a6e61
Autor:
Peirong Cai, Zhiheng Feng, Nannan Feng, Hui Zou, Jianhong Gu, Xuezhong Liu, Zongping Liu, Yan Yuan, Jianchun Bian
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 220, Iss , Pp 112367- (2021)
Zearalenone, which is ubiquitous in grains and animal feed, is a mycotoxin that can cause serious damage to animals and humans. Sertoli cells (SCs) can be used to study ZEA male reproductive toxicity in vitro. SCs provide energy for germ cells, where
Externí odkaz:
https://doaj.org/article/9d557f6d1fe04781aedaf024c5da8666
Autor:
Yilai Shu, Wenyan Li, Mingqian Huang, Yi-Zhou Quan, Deborah Scheffer, Chunjie Tian, Yong Tao, Xuezhong Liu, Konrad Hochedlinger, Artur A. Indzhykulian, Zhengmin Wang, Huawei Li, Zheng-Yi Chen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
The adult mammalian inner ear cells cannot regenerate nor proliferate. Here, the authors show that co-activation of Myc and NOTCH pathways can stimulate proliferation of inner ear sensory epithelial cells, which can be induced to become hair cell-lik
Externí odkaz:
https://doaj.org/article/ffede07f9adb4b84bc66e2e78aa02c57
Autor:
Christine Mei, Hongsong Dong, Eric Nisenbaum, Torin Thielhelm, Aida Nourbakhsh, Denise Yan, Molly Smeal, Yesha Lundberg, Michael E. Hoffer, Simon Angeli, Fred Telischi, Guohui Nie, Susan H. Blanton, Xuezhong Liu
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Background: Vestibular disorders (VDs) are a clinically divergent group of conditions that stem from pathology at the level of the inner ear, vestibulocochlear nerve, or central vestibular pathway. No etiology can be identified in the majority of pat
Externí odkaz:
https://doaj.org/article/d012615d536e4cb5bf8dc13a57e26148