Výsledky vyhledávání

Akademický článek

Butyrate attenuates sympathetic activation in rats with chronic heart failure by inhibiting microglial inflammation in the paraventricular nucleus

Autor: Liu Chang, Yu Hao, Xia Hongyi, Wang Ziwei, Li Bolin, Xue Hongmei, Jin Sheng, Xiao Lin, Wu Yuming, Guo Qi

Publikováno v: Acta Biochimica et Biophysica Sinica, Vol 56, Pp 1823-1832 (2024)

Sympathetic activation is a hallmark of heart failure and the underlying mechanism remains elusive. Butyrate is generated by gut microbiota and influences numerous physiological and pathological processes in the host. The present study aims to invest

Externí odkaz: https://doaj.org/article/4b242814950e450d8330babf8bfd5142

Zobrazit plný text záznamu

Akademický článek

Hydrogen sulfide ameliorates senescence in vascular endothelial cells through ameliorating inflammation and activating PPARδ/SGLT2/STAT3 signaling pathway

Autor: Tian Danyang, Meng Jinqi, Li Lin, Xue Hongmei, Geng Qi, Miao Yuxin, Xu Meng, Wang Ru, Zhang Xiangjian, Wu Yuming

Publikováno v: Acta Biochimica et Biophysica Sinica, Vol 55, Pp 1358-1369 (2023)

Mounting evidence demonstrates that hydrogen sulfide (H2S) promotes anti-inflammatory molecules and inhibits pro-inflammatory cytokines in endothelial cells (ECs). This study aims to investigate the favorable action of H2S on endothelial function in

Externí odkaz: https://doaj.org/article/47ff80b823d5443faaa1a02752c31991

Zobrazit plný text záznamu

Akademický článek

Endoplasmic reticulum stress mediates homocysteine-induced hypertrophy of cardiac cells through activation of cyclic nucleotide phosphodiesterase 1C

Autor: Sun Wentao, Zhou Yang, Xue Hongmei, Hou Haitao, He Guowei, Yang Qin

Publikováno v: Acta Biochimica et Biophysica Sinica, Vol 54, Pp 388-399 (2022)

Although the association of elevated homocysteine level with cardiac hypertrophy has been reported, the molecular mechanisms by which homocysteine induces cardiac hypertrophy remain inadequately understood. In this study we aim to uncover the roles o

Externí odkaz: https://doaj.org/article/332927bc16db44d3ab2b3a81fb3d5ab3

Zobrazit plný text záznamu