Zobrazeno 1 - 10
of 17
pro vyhledávání: '"XP, extra precision"'
Autor:
Yanfei Cai, Jingyu Zhu, Yun Chen, Jian Jin, Xinling Zhao, Kan Li, Lei Xu, Huazhong Li, Gang Huang
Publikováno v:
Journal of Advanced Research
Journal of Advanced Research, Vol 36, Iss, Pp 1-13 (2022)
Journal of Advanced Research, Vol 36, Iss, Pp 1-13 (2022)
Graphical abstract
Highlights • Virtual screening based on machine learning with multiple proteins was developed. • Discovery of a novel PI3Kγ inhibitor integrating virtual screening and bio-assays. • JN-KI3 selective inhibit PI3Kγ enzym
Highlights • Virtual screening based on machine learning with multiple proteins was developed. • Discovery of a novel PI3Kγ inhibitor integrating virtual screening and bio-assays. • JN-KI3 selective inhibit PI3Kγ enzym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cdbf7fb8f578b72a0c3242e69513c71
https://doi.org/10.1016/j.jare.2021.04.007
https://doi.org/10.1016/j.jare.2021.04.007
Identification of Mpro inhibitors of SARS-CoV-2 using structure based computational drug repurposing
Publikováno v:
Biocatalysis and Agricultural Biotechnology
The recent outbreak of COVID-19, caused by the novel pathogen SARS-coronavirus 2 (SARS-CoV-2) is a severe health emergency. In this pandemic, drug repurposing seems to be the most promising alternative to identify effective therapeutic agents for imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d64012a07aa96e2be16fd8f2578e1ca
https://doi.org/10.1016/j.bcab.2021.102178
https://doi.org/10.1016/j.bcab.2021.102178
Autor:
Lingxia Zhu, Peng Cao, Yonghua Zhu, Jiao Chen, Rafael Rosell, Yuhan Yang, Chunping Hu, Xiaoyan Sun, Xueting Cai, Jiayu Zhao, Yang Yang, Jiaqi Wang
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 4, Pp 603-614 (2020)
Acta Pharmaceutica Sinica B, Vol 10, Iss 4, Pp 603-614 (2020)
Pancreatic cancer is one of the most aggressive cancers with poor prognosis and a low 5-year survival rate. The family of P21-activated kinases (PAKs) appears to modulate many signaling pathways that contribute to pancreatic carcinogenesis. In this w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0913dd0c804696dd82046e2f7cdf6b50
https://pubmed.ncbi.nlm.nih.gov/32322465
https://pubmed.ncbi.nlm.nih.gov/32322465
Akademický článek
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Akademický článek
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Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
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Autor:
Nath V; Department of Pharmacy, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Ajmer, India., Rohini A; College of Pharmacy, JSS Academy of Technical Sciences, Noida, Uttar Pradesh, India., Kumar V; Department of Pharmacy, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Ajmer, India.
Publikováno v:
Biocatalysis and agricultural biotechnology [Biocatal Agric Biotechnol] 2021 Oct; Vol. 37, pp. 102178. Date of Electronic Publication: 2021 Oct 01.
Autor:
Zhu J; School of Pharmaceutical Sciences, Jiangnan University, Wuxi, Jiangsu 214122, China., Li K; School of Pharmaceutical Sciences, Jiangnan University, Wuxi, Jiangsu 214122, China., Xu L; Institute of Bioinformatics and Medical Engineering, School of Electrical and Information Engineering, Jiangsu University of Technology, Changzhou 213001, China., Cai Y; School of Pharmaceutical Sciences, Jiangnan University, Wuxi, Jiangsu 214122, China., Chen Y; School of Pharmaceutical Sciences, Jiangnan University, Wuxi, Jiangsu 214122, China., Zhao X; School of Pharmaceutical Sciences, Jiangnan University, Wuxi, Jiangsu 214122, China., Li H; School of Biotechnology, Jiangnan University, Wuxi, Jiangsu 21412 2, China., Huang G; Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China., Jin J; School of Pharmaceutical Sciences, Jiangnan University, Wuxi, Jiangsu 214122, China.
Publikováno v:
Journal of advanced research [J Adv Res] 2021 Apr 20; Vol. 36, pp. 1-13. Date of Electronic Publication: 2021 Apr 20 (Print Publication: 2022).
Autor:
Wang J; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China.; Department of Pharmacology, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.; Laboratory of Cellular and Molecular Biology, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, China., Zhu Y; Fullshare Health College, Nanjing University of Chinese Medicine, Nanjing 210023, China., Chen J; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China.; Department of Pharmacology, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.; Laboratory of Cellular and Molecular Biology, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, China., Yang Y; Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China., Zhu L; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China.; Department of Pharmacology, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.; Laboratory of Cellular and Molecular Biology, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, China., Zhao J; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China.; Department of Pharmacology, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.; Laboratory of Cellular and Molecular Biology, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, China., Yang Y; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China.; Department of Pharmacology, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.; Laboratory of Cellular and Molecular Biology, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, China., Cai X; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China.; Department of Pharmacology, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.; Laboratory of Cellular and Molecular Biology, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, China., Hu C; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China.; Department of Pharmacology, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.; Laboratory of Cellular and Molecular Biology, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, China., Rosell R; Cancer Biology and Precision Medicine Program, Germans Trias i Pujol University Hospital, Badalona, Badalona 08916, Spain., Sun X; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China.; Department of Pharmacology, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.; Laboratory of Cellular and Molecular Biology, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, China., Cao P; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China.; Department of Pharmacology, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.; Laboratory of Cellular and Molecular Biology, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, China.; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Jiangsu Collaborative Innovation Center For Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
Publikováno v:
Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2020 Apr; Vol. 10 (4), pp. 603-614. Date of Electronic Publication: 2019 Dec 16.