Zobrazeno 1 - 10
of 265
pro vyhledávání: '"XLF"'
Akademický článek
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Autor:
Shirly Frizinsky, Erez Rechavi, Ortal Barel, Yu Nee Lee, Amos J. Simon, Atar Lev, Tali Stauber, Etai Adam, Raz Somech
Publikováno v:
Frontiers in Pediatrics, Vol 10 (2022)
BackgroundDuring the process of generating diverse T and B cell receptor (TCR and BCR, respectively) repertoires, double-strand DNA breaks are produced. Subsequently, these breaks are corrected by a complex system led by the non-homologous end-joinin
Externí odkaz:
https://doaj.org/article/4b302d93034d4c11abf8ea09476eb014
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Non-homologous end joining (cNHEJ) is a major pathway to repair double-strand breaks (DSBs) in DNA. Several core cNHEJ are involved in the progress of the repair such as KU70 and 80, DNA-dependent protein kinase catalytic subunit (DNA-PKcs), Artemis,
Externí odkaz:
https://doaj.org/article/c48a3730c87b4ded81acc7b9b51d80d3
Publikováno v:
Drug Design, Development and Therapy, Vol Volume 13, Pp 3823-3834 (2019)
Zhuo Liu,1 Miao Yu,1 Bingyuan Fei,1 Jing Sun,2 Dongxin Wang3 1Department of Gastrointestinal Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin, People’s Republic of China; 2Department of Biochemistry and
Externí odkaz:
https://doaj.org/article/abfae9a43d50400cbaa79204165ad9de
Publikováno v:
Frontiers in Pediatrics, Vol 7 (2020)
The ubiquitous presence of enzymes required for repair of DNA double strand breaks renders patients with defects in these pathways susceptible to immunodeficiency, an increased risk of infection, autoimmunity, bone marrow failure and malignancies, wh
Externí odkaz:
https://doaj.org/article/934d6f72485e4d0e953cbc8a5b8f44ed
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
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Autor:
Sitian Yang, Xiao Qi Wang
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-10 (2017)
Abstract Background DNA repair pathways are used by cancer cells to overcome many standard anticancer treatments, causing therapy resistance. Here, we investigated the role of XRCC4-like factor (XLF), a core member of the non-homologous end joining (
Externí odkaz:
https://doaj.org/article/e59b3210461947b4bc539c0c27c363f3
Autor:
Maria J. Recio, Nerea Dominguez-Pinilla, Melina Soledad Perrig, Carmen Rodriguez Vigil-Iturrate, Nerea Salmón-Rodriguez, Cristina Martinez Faci, María J. Castro-Panete, Javier Blas-Espada, Marta López-Nevado, Raquel Ruiz-Garcia, Rebeca Chaparro-García, Luis M. Allende, Luis Ignacio Gonzalez-Granado
Publikováno v:
Frontiers in Immunology, Vol 9 (2019)
Cernunnos/XLF deficiency is a rare primary immunodeficiency classified within the DNA repair defects. Patients present with severe growth retardation, microcephaly, lymphopenia and increased cellular sensitivity to ionizing radiation. Here, we descri
Externí odkaz:
https://doaj.org/article/60b1ef43446645559d00f8c2778e5f28
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2016 Sep . 113(38), 10619-10624.
Externí odkaz:
https://www.jstor.org/stable/26471638
Autor:
Satish K. Tadi, Carine Tellier-Lebègue, Clément Nemoz, Pascal Drevet, Stéphane Audebert, Sunetra Roy, Katheryn Meek, Jean-Baptiste Charbonnier, Mauro Modesti
Publikováno v:
Cell Reports, Vol 17, Iss 2, Pp 541-555 (2016)
In mammalian cells, classical non-homologous end joining (c-NHEJ) is critical for DNA double-strand break repair induced by ionizing radiation and during V(D)J recombination in developing B and T lymphocytes. Recently, PAXX was identified as a c-NHEJ
Externí odkaz:
https://doaj.org/article/c861e7cc7c714c09a07a270f4bfd07e7