Zobrazeno 1 - 10
of 1 184
pro vyhledávání: '"XIONG Ji"'
Publikováno v:
STAR Protocols, Vol 4, Iss 3, Pp 102356- (2023)
Summary: Sequencing chromatin-associated RNA using libraries from the chromatin fraction makes it possible to characterize RNA processing driven by disassociated subunits. Here, we present an experimental strategy and computational pipeline for proce
Externí odkaz:
https://doaj.org/article/f995dcb7f94642aa8cea614dce909e29
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112941- (2023)
Summary: RNA polymerase III (Pol III) plays a vital role in transcription and as a viral-DNA sensor, but how it is assembled and distributed within cells remains poorly understood. Here, we show that Pol III is assembled with chaperones in the cytopl
Externí odkaz:
https://doaj.org/article/7e4cdf37cddc4343be671afc1e8c2cae
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-37 (2022)
Abstract Background Mammalian cells have three types of RNA polymerases (Pols), Pol I, II, and III. However, the extent to which these polymerases are cross-regulated and the underlying mechanisms remain unclear. Results We employ genome-wide profili
Externí odkaz:
https://doaj.org/article/bd582bf29c8f445391be4e69fe2a8d99
Autor:
Hui Wang, Boyuan Li, Linyu Zuo, Bo Wang, Yan Yan, Kai Tian, Rong Zhou, Chenlu Wang, Xizi Chen, Yongpeng Jiang, Haonan Zheng, Fangfei Qin, Bin Zhang, Yang Yu, Chao-Pei Liu, Yanhui Xu, Juntao Gao, Zhi Qi, Wulan Deng, Xiong Ji
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-26 (2022)
RNA polymerase II (Pol II) transcription factories play a central role in gene expression and 3D chromatin organization. Here, the authors demonstrate that RUVBL2 directly regulates Pol II clustering at active gene promoters.
Externí odkaz:
https://doaj.org/article/b2515b94263f46c690eb47a252390402
Publikováno v:
STAR Protocols, Vol 4, Iss 2, Pp 102202- (2023)
Summary: Clustering of RNA polymerase II carboxy-terminal domain (CTD) and CTCF DNA-binding domains (DBDs) have been viewed as emerging mechanisms of transcription regulation and three-dimensional chromatin organization. In this protocol, we address
Externí odkaz:
https://doaj.org/article/0546505153884575a3e862040b4f8e71
Autor:
Rong Zhou, Kai Tian, Jie Huang, Wenjia Duan, Hongye Fu, Ying Feng, Hui Wang, Yongpeng Jiang, Yuanjun Li, Rui Wang, Jiazhi Hu, Hanhui Ma, Zhi Qi, Xiong Ji
Publikováno v:
iScience, Vol 25, Iss 9, Pp 105011- (2022)
Summary: CTCF is a predominant insulator protein required for three-dimensional chromatin organization. However, the roles of its insulation of enhancers in a 3D nuclear organization have not been fully explained. Here, we found that the CTCF DNA-bin
Externí odkaz:
https://doaj.org/article/7e8c6a2bad8943179c6a38dd6e1a14f1
Autor:
Yang Liu, Chen Ai, Tingting Gan, Jinchun Wu, Yongpeng Jiang, Xuhao Liu, Rusen Lu, Ning Gao, Qing Li, Xiong Ji, Jiazhi Hu
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-27 (2021)
Abstract Background Early DNA replication occurs within actively transcribed chromatin compartments in mammalian cells, raising the immediate question of how early DNA replication coordinates with transcription to avoid collisions and DNA damage. Res
Externí odkaz:
https://doaj.org/article/aaadb8da280347eba3f0d8eb1e4aa311
Autor:
Lili Cao, Yujie Luo, Xuefei Guo, Shengde Liu, Siji Li, Junhong Li, Zeming Zhang, Yingchi Zhao, Qiao Zhang, Feng Gao, Xiong Ji, Xiang Gao, Yunfei Li, Fuping You
Publikováno v:
PLoS Pathogens, Vol 18, Iss 6, p e1010599 (2022)
Regulation of chromatin structure and accessibility determines the transcription activities of genes, which endows the host with function-specific patterns of gene expression. Upon viral infection, the innate immune responses provide the first line o
Externí odkaz:
https://doaj.org/article/49852bb063ba48edac37daf068a96678
Autor:
Bo Yang, Boyuan Li, Liyang Jia, Yongpeng Jiang, Xin Wang, Shaodong Jiang, Shunda Du, Xiong Ji, Pengyuan Yang
Publikováno v:
Cell Discovery, Vol 6, Iss 1, Pp 1-12 (2020)
Abstract Hepatitis B viral (HBV) DNAs, including covalently closed circular DNA (cccDNA) and integrated HBV DNA forms, are considered to be primary contributors to the development and progression of HBV-associated liver diseases. However, it remains
Externí odkaz:
https://doaj.org/article/a4313746a2774c649d5e8b8c35a618c9
Autor:
Yongpeng Jiang, Jie Huang, Kehuan Lun, Boyuan Li, Haonan Zheng, Yuanjun Li, Rong Zhou, Wenjia Duan, Chenlu Wang, Yuanqing Feng, Hong Yao, Cheng Li, Xiong Ji
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-28 (2020)
Abstract Background The relationship between transcription and the 3D chromatin structure is debated. Multiple studies have shown that transcription affects global Cohesin binding and 3D genome structures. However, several other studies have indicate
Externí odkaz:
https://doaj.org/article/39b6292b3d024683b964eace154d7c75