Investigation of Hot Spot Region in XIAP Inhibitor Binding Site by Fragment Molecular Orbital Method

Autor: Ki Beom Shin, Hocheol Lim, Jongwan Kim, Ky Youb Nam, Jiwon Choi, Xuemei Jin, Kyoung Tai No, Sungbo Hwang

Publikováno v: Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 17, Iss, Pp 1217-1225 (2019)

X-linked inhibitor of apoptosis protein (XIAP) is an important regulator of cancer cell survival whose BIR3 domain (XIAP-BIR3) recognizes the Smac N-terminal tetrapeptide sequence (AVPI), making it an attractive protein-protein interaction (PPI) targ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::846bf79946fc3f084b4f54bfe22d3220
https://doi.org/10.1016/j.csbj.2019.08.004