Zobrazeno 1 - 10
of 2 117
pro vyhledávání: '"XENOBIOTIC METABOLISM"'
Autor:
Fan-Zhu Meng, Wen-Kai Wei, Min-Zheng Cai, Zuo-Qian Wang, Liang-Fen Yin, Wei-Xiao Yin, Guido Schnabel, Chao-Xi Luo
Publikováno v:
mBio, Vol 15, Iss 12 (2024)
ABSTRACT Rice blast caused by Magnaporthe oryzae is one of the most economically important rice diseases. Fungicides such as isoprothiolane (IPT) have been used extensively for rice blast control, but resistance to IPT in M. oryzae is an emerging thr
Externí odkaz:
https://doaj.org/article/452b2ec250b84881a2ee5489fe10cad7
Publikováno v:
Toxicology Reports, Vol 13, Iss , Pp 101752- (2024)
Enzyme kinetic parameters for aflatoxin B1 metabolism have been reported for chicken, quail, turkey and duck, but an integrated in silico model has not been proposed. Both enzyme-catalyzed reactions and spontaneous reactions were modeled in the CellD
Externí odkaz:
https://doaj.org/article/e3ab7f3636bb4aa3abcf4f5068292a9e
Autor:
M. Friberg, A. F. Behndig, J. A. Bosson, Ala Muala, S. Barath, R. Dove, D. Glencross, F. J. Kelly, A. Blomberg, I. S. Mudway, T. Sandström, J. Pourazar
Publikováno v:
Particle and Fibre Toxicology, Vol 20, Iss 1, Pp 1-13 (2023)
Abstract Background Diesel exhaust (DE) induces neutrophilia and lymphocytosis in experimentally exposed humans. These responses occur in parallel to nuclear migration of NF-κB and c-Jun, activation of mitogen activated protein kinases and increased
Externí odkaz:
https://doaj.org/article/e9531d56fc7c476fb68512267664b83d
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-28 (2023)
Abstract Background The radiation of mammals at the extinction of the dinosaurs produced a plethora of new forms—as diverse as bats, dolphins, and elephants—in only 10–20 million years. Behind the scenes, adaptation to new niches is accompanied
Externí odkaz:
https://doaj.org/article/0623f6af69774b5a9c205a95b9dcc6aa
Publikováno v:
Успехи молекулярной онкологии, Vol 10, Iss 2, Pp 30-41 (2023)
Genetic apparatus of human cells is constantly affected by a broad spectrum of mutagenic factors, both exogenous and endogenous. Genetic and epigenetic disorders, which emerge as a result of this influence, become the main cause of the majority of ma
Externí odkaz:
https://doaj.org/article/afaf993f0c09406297b6ebe7ff848498
Autor:
Marine Huillet, Frédéric Lasserre, Marie-Pierre Gratacap, Beatrice Engelmann, Justine Bruse, Arnaud Polizzi, Tiffany Fougeray, Céline Marie Pauline Martin, Clémence Rives, Anne Fougerat, Claire Naylies, Yannick Lippi, Géraldine Garcia, Elodie Rousseau-Bacquie, Cécile Canlet, Laurent Debrauwer, Ulrike Rolle-Kampczyk, Martin von Bergen, Bernard Payrastre, Elisa Boutet-Robinet, Laurence Gamet-Payrastre, Hervé Guillou, Nicolas Loiseau, Sandrine Ellero-Simatos
Publikováno v:
JHEP Reports, Vol 6, Iss 1, Pp 100930- (2024)
Background & Aims: The constitutive androstane receptor (CAR) is a nuclear receptor that binds diverse xenobiotics and whose activation leads to the modulation of the expression of target genes involved in xenobiotic detoxification and energy metabol
Externí odkaz:
https://doaj.org/article/17ee943087754a249afd56b554637a6c
Publikováno v:
BMC Pregnancy and Childbirth, Vol 23, Iss 1, Pp 1-13 (2023)
Abstract Background Cytochrome P450 2E1 (CYP2E1) plays a key role in the metabolism of xenobiotic and endogenous low-molecular-weight compounds. This study aimed to determine if the genetic variations of 96-bp insertion/deletion (I/D) and C-1054T (rs
Externí odkaz:
https://doaj.org/article/c7d84bc30d4a440483c13555e73a35af
Autor:
Shen Chen, Miao Li, Rui Zhang, Lizhu Ye, Yue Jiang, Xinhang Jiang, Hui Peng, Ziwei Wang, Zhanyu Guo, Liping Chen, Rong Zhang, Yujie Niu, Michael Aschner, Daochuan Li, Wen Chen
Publikováno v:
Particle and Fibre Toxicology, Vol 20, Iss 1, Pp 1-17 (2023)
Abstract Background Pre-existing metabolic diseases may predispose individuals to particulate matter (PM)-induced adverse health effects. However, the differences in susceptibility of various metabolic diseases to PM-induced lung injury and their und
Externí odkaz:
https://doaj.org/article/161cfbd6a0ce4f33a2f23e6192b2f391
Autor:
Olavi Pelkonen, Khaled Abass, Juan Manuel Parra Morte, Martina Panzarea, Emanuela Testai, Serge Rudaz, Jochem Louisse, Ursula Gundert-Remy, Gerrit Wolterink, Dorne Jean-Lou CM, Sandra Coecke, Camilla Bernasconi
Publikováno v:
Frontiers in Toxicology, Vol 5 (2023)
A large majority of chemicals is converted into metabolites through xenobiotic-metabolising enzymes. Metabolites may present a spectrum of characteristics varying from similar to vastly different compared with the parent compound in terms of both tox
Externí odkaz:
https://doaj.org/article/2feb36a65c8c49e1b8fa256be6ef6c18
Autor:
Lindsey M. Pieper, Peter Spanogiannopoulos, Regan F. Volk, Carson J. Miller, Aaron T. Wright, Peter J. Turnbaugh
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT The microbiome is an underappreciated contributor to intestinal drug metabolism with broad implications for drug efficacy and toxicity. While considerable progress has been made toward identifying the gut bacterial genes and enzymes involved
Externí odkaz:
https://doaj.org/article/f83c7a0eeaf4426f93a48cd22b21ff80