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pro vyhledávání: '"X.-S. Pan"'
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Publikováno v:
Water Resources. 44:43-51
In-depth studies of water and sediment fluxes from rivers into the sea are very important for understanding the interactions between land and sea. This paper is concerned with identifying the changes in the time series of water and sediment fluxes fr
Akademický článek
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Autor:
Mark R. Sanderson, Trishant R. Umrekar, L. Mark Fisher, Galyna B. Skamrova, X.-S. Pan, D.A. Veselkov, Ivan Laponogov
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Laponogov, I, Pan, X S, Veselkov, D A, Skamrova, G B, Umrekar, T R, Fisher, L M & Sanderson, M R 2018, ' Trapping of the transport-segment DNA by the ATPase domains of a type II topoisomerase ', Nature Communications, vol. 9, no. 1, 2579 . https://doi.org/10.1038/s41467-018-05005-x
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Laponogov, I, Pan, X S, Veselkov, D A, Skamrova, G B, Umrekar, T R, Fisher, L M & Sanderson, M R 2018, ' Trapping of the transport-segment DNA by the ATPase domains of a type II topoisomerase ', Nature Communications, vol. 9, no. 1, 2579 . https://doi.org/10.1038/s41467-018-05005-x
Type II topoisomerases alter DNA topology to control DNA supercoiling and chromosome segregation and are targets of clinically important anti-infective and anticancer therapeutics. They act as ATP-operated clamps to trap a DNA helix and transport it
Autor:
Ryan Cirz, D.A. Veselkov, X.-S. Pan, Heinz E. Moser, Isabelle M.-T. Crevel, Art Branstrom, Mark R. Sanderson, Ivan Laponogov, L. Mark Fisher, Jogitha Selvarajah
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b1798ea4dbd69d476b9c8c0cbd8ac8d
https://openaccess.sgul.ac.uk/id/eprint/111159/1/a55730.pdf
https://openaccess.sgul.ac.uk/id/eprint/111159/1/a55730.pdf
Akademický článek
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Publikováno v:
Nucleic Acids Research
Antibacterial fluoroquinolones trap a cleavage complex of gyrase and topoisomerase (topo) IV inducing site-specific DNA breakage within a bent DNA gate engaged in DNA transport. Despite its importance for drug action and in revealing potential sites
Publikováno v:
Antimicrobial Agents and Chemotherapy. 53:3822-3831
Quinazoline-2,4-diones, such as PD 0305970, are new DNA gyrase and topoisomerase IV (topo IV) inhibitors with potent activity against gram-positive pathogens, including quinolone-resistant isolates. The mechanistic basis of dione activity vis-à-vis
Autor:
Céline Corbel, Emmanuelle Cambau, Jean-Yves Driot, X.-S. Pan, L. Mark Fisher, Stéphanie Matrat, C. Lascols, Romain Roth Dit Bettoni, Alexandra Aubry
Publikováno v:
Journal of Antimicrobial Chemotherapy. 63:443-450
Objectives Besifloxacin is a new fluoroquinolone in development for ocular use. We investigated its mode of action and resistance in two major ocular pathogens, Streptococcus pneumoniae and Staphylococcus aureus, and in the reference species Escheric
Autor:
Katherine McAuley, X.-S. Pan, A.W. Thompson, D.A. Veselkov, M.K. Sohi, L.M. Fisher, Mark R. Sanderson, Ivan Laponogov, R. Sawhney
Publikováno v:
Nature Structural & Molecular Biology. 16:667-669
Type II topoisomerases alter DNA topology by forming a covalent DNA-cleavage complex that allows DNA transport through a double-stranded DNA break. We present the structures of cleavage complexes formed by the Streptococcus pneumoniae ParC breakage-r