Zobrazeno 1 - 10
of 101
pro vyhledávání: '"X. William, Yang"'
DNA methylation study of Huntington’s disease and motor progression in patients and in animal models
Autor:
Ake T. Lu, Pritika Narayan, Matthew J. Grant, Peter Langfelder, Nan Wang, Seung Kwak, Hilary Wilkinson, Richard Z. Chen, Jian Chen, C. Simon Bawden, Skye R. Rudiger, Marc Ciosi, Afroditi Chatzi, Alastair Maxwell, Timothy A. Hore, Jeff Aaronson, Jim Rosinski, Alicia Preiss, Thomas F. Vogt, Giovanni Coppola, Darren Monckton, Russell G. Snell, X. William Yang, Steve Horvath
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Although Huntington’s disease (HD) is a well-studied genetic disorder, less is known about the epigenetic changes underlying it. Here, the authors characterize DNA methylation levels in tissues from patients, a mouse huntingtin (Htt) gene knock-in
Externí odkaz:
https://doaj.org/article/9415f3c0bb6441ffad6d13aeb09b8ee8
Autor:
Rui Li, Muye Zhu, Junning Li, Michael S. Bienkowski, Nicholas N. Foster, Hanpeng Xu, Tyler Ard, Ian Bowman, Changle Zhou, Matthew B. Veldman, X. William Yang, Houri Hintiryan, Junsong Zhang, Hong-Wei Dong
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Most neuronal reconstruction software can automatically trace single neuronal morphologies but tracing multiple, densely interwoven neurons is much more challenging. Here the authors develop G-Cut, a computational approach for accurate segmentation o
Externí odkaz:
https://doaj.org/article/23743cd1ee8540e88902866335c58b30
Autor:
Daniel O'Reilly, Jillian Belgrad, Chantal Ferguson, Ashley Summers, Ellen Sapp, Cassandra McHugh, Ella Mathews, Adel Boudi, Julianna Buchwald, Socheata Ly, Dimas Moreno, Raymond Furgal, Eric Luu, Zachary Kennedy, Vignesh Hariharan, Kathryn Monopoli, X. William Yang, Jeffery Carroll, Marian DiFiglia, Neil Aronin, Anastasia Khvorova
Publikováno v:
Molecular Therapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88d44db32c4893997bcd51e5eccde0fb
https://doi.org/10.1016/j.ymthe.2023.05.006
https://doi.org/10.1016/j.ymthe.2023.05.006
Autor:
Peter Langfelder, Fuying Gao, Nan Wang, David Howland, Seung Kwak, Thomas F Vogt, Jeffrey S Aaronson, Jim Rosinski, Giovanni Coppola, Steve Horvath, X William Yang
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0190550 (2018)
In Huntington's disease (HD) patients and in model organisms, messenger RNA transcriptome has been extensively studied; in contrast, comparatively little is known about expression and potential role of microRNAs. Using RNA-sequencing, we have quantif
Externí odkaz:
https://doaj.org/article/b8777b2d13824572b2030ef761c7666a
Autor:
Judith Mizrachi, Partha P. Mitra, Arun Narasimhan, Philip R. Nicovich, Sarojini M. Attili, Hideki Kondo, Pavel Osten, Muye Zhu, Brian Zingg, Anthony M. Zador, Stephan Fischer, William Galbavy, Uree Chon, Liya Ding, Stephanie Mok, Kwanghun Chung, Florence D’Orazi, Xu An, Shenqin Yao, Philip Lesnar, Wayne Wakemen, James C. Gee, Darrick Lo, Kathleen Kelly, Ian Bowman, Lydia Ng, Peng Xie, Quanxin Wang, Karla E. Hirokawa, X. William Yang, Julie A. Harris, Xiuli Kuang, Huizhong W. Tao, Samik Bannerjee, Elise Shen, Xu Li, Z. Josh Huang, Ali Cetin, Young Gyun Park, Lijuan Liu, Corey Elowsky, Xiangning Li, Lin Gou, Hong-Wei Dong, Laura Korobkova, Joshua T. Hatfield, Junxiang Jason Huang, Hui Gong, Yun Wang, Houri Hintiryan, Nicholas N. Foster, Peter A. Groblewski, Michael S. Bienkowski, Diek W. Wheeler, Xiaoyin Chen, Yu-Chi Sun, Anastasiia Bludova, Maitham Naeemi, Rodrigo Muñoz-Castañeda, Joel D. Hahn, Jing Yuan, Hanchuan Peng, Katherine Matho, Jason Palmer, Huiqing Zhan, Yimin Wang, Hongkui Zeng, Michael Hawrylycz, Chris Sin Park, Li I. Zhang, Rhonda Drewes, Ramesh Palaniswamy, Bing-Xing Huo, Anan Li, Yongsoo Kim, Jesse Gillis, Byung Kook Lim, Lei Gao, Giorgio A. Ascoli, Xiaoli Qi, Meng Kuan Lin, Yaoyao Li, Qingming Luo
Publikováno v:
Nature
An essential step toward understanding brain function is to establish a structural framework with cellular resolution on which multi-scale datasets spanning molecules, cells, circuits and systems can be integrated and interpreted1. Here, as part of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69a9d6eb17e664b75265f08198a32b92
https://doi.org/10.1038/s41586-021-03970-w
https://doi.org/10.1038/s41586-021-03970-w
Autor:
Ian R. Wickersham, Nora L. Benavidez, Jun-Hyeok Choi, Jim Stanis, Tao Jiang, Yasmine Sherafat, Marlene Becerra, Amanda J. Tugangui, Lin Gou, Hong-Wei Dong, Byung Kook Lim, Hui Gong, Nicholas N. Foster, Xiangning Li, Hyun-Seung Mun, Zhao Feng, Ian Bowman, Anthony Santarelli, Joshua Barry, Luis Garcia, Lei Gao, Muye Zhu, Gordon Dan, Qingming Luo, Brian Zingg, Tyler Boesen, David L. Johnson, Sarvia Aquino, Marina Fayzullina, Darrick Lo, Neda Khanjani, Joel D. Hahn, Bo Peng, X. William Yang, Monica Song, Carlos Cepeda, Anan Li, Sarah Ustrell, Michael S. Bienkowski, Chunru Cao, Seita Yamashita, Houri Hintiryan, Sana Azam, Xueyan Jia, Hanpeng Xu, Bin Zhang, Michael Levine, Li I. Zhang, Kaelan Cotter, Laura Korobkova
Publikováno v:
Nature
The cortico–basal ganglia–thalamo–cortical loop is one of the fundamental network motifs in the brain. Revealing its structural and functional organization is critical to understanding cognition, sensorimotor behaviour, and the natural history
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6ef9a0f5e8e7d23c88097df7f7603ee
http://europepmc.org/articles/PMC8494639
http://europepmc.org/articles/PMC8494639
Autor:
Leonardo E. Dionisio, X. William Yang
Publikováno v:
Cell Systems. 13:268-270
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d6cd8877a7a36ba32cba1736705b2a1
https://doi.org/10.1016/j.cels.2022.03.003
https://doi.org/10.1016/j.cels.2022.03.003
Autor:
Daniel O’Reilly, Jillian Belgrad, Chantal Ferguson, Ashley Summers, Ellen Sapp, Cassandra McHugh, Ella Mathews, Julianna Buchwald, Socheata Ly, Dimas Echeverria Moreno, Zachary Kennedy, Vignesh Hariharan, Kathryn Monopoli, X. William Yang, Jeffery Carroll, Marian DiFiglia, Neil Aronin, Anastasia Khvorova
Huntington’s Disease (HD) is a severe neurodegenerative disorder caused by expansion of the CAG trinucleotide repeat tract in the huntingtin gene. Inheritance of expanded CAG repeats is needed for HD manifestation, but further somatic expansion of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b85abae4738303ac45e081a5dee520ab
https://doi.org/10.1101/2022.09.06.506795
https://doi.org/10.1101/2022.09.06.506795
Autor:
Nan Wang, Peter Langfelder, Matthew Stricos, Lalini Ramanathan, Jeffrey B. Richman, Raymond Vaca, Mary Plascencia, Xiaofeng Gu, Shasha Zhang, T. Katherine Tamai, Liguo Zhang, Fuying Gao, Koliane Ouk, Xiang Lu, Leonid V. Ivanov, Thomas F. Vogt, Qing Richard Lu, A. Jennifer Morton, Christopher S. Colwell, Jeffrey S. Aaronson, Jim Rosinski, Steve Horvath, X. William Yang
Publikováno v:
Neuron. 110(20)
Brain tissue transcriptomes may be organized into gene coexpression networks, but their underlying biological drivers remain incompletely understood. Here, we undertook a large-scale transcriptomic study using 508 wild-type mouse striatal tissue samp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::102cf3176c3176500f2ba80c16ba4a22
https://pubmed.ncbi.nlm.nih.gov/36265442
https://pubmed.ncbi.nlm.nih.gov/36265442
Autor:
Xiaofeng Gu, Jeffrey Richman, Peter Langfelder, Nan Wang, Shasha Zhang, Monica Bañez-Coronel, Huei-Bin Wang, Lucia Yang, Lalini Ramanathan, Linna Deng, Chang Sin Park, Christopher R. Choi, Jeffrey P. Cantle, Fuying Gao, Michelle Gray, Giovanni Coppola, Gillian P. Bates, Laura P.W. Ranum, Steve Horvath, Christopher S. Colwell, X. William Yang
Publikováno v:
Neuron, vol 110, iss 7
In Huntington's disease (HD), the uninterrupted CAG repeat length, but not the polyglutamine length, predicts disease onset. However, the underlying pathobiology remains unclear. Here, we developed bacterial artificial chromosome (BAC) transgenic mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b04693f7ac3c7c68110e9b998475b45c
https://escholarship.org/uc/item/52k97025
https://escholarship.org/uc/item/52k97025