Výsledky vyhledávání - "X. P. Ioannou"

Safety of CpG Oligodeoxynucleotides in Veterinary Species

Autor: George Mutwiri, A. Mena, X. P. Ioannou, S. Van Drunen Littel-Van Den Hurk, Dale L. Godson, Rolf Hecker, Lorne A. Babiuk, P. Griebel, Susantha Gomis

Publikováno v: Antisense and Nucleic Acid Drug Development. 13:157-167

Bacterial DNA and synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs in particular sequence contexts (CpG ODN) are recognized as a danger signal by the innate immune system of vertebrates. For this reason, CpG ODNs have a poten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57793fac662000f21f95a525142e78b1
https://doi.org/10.1089/108729003768247628

Zobrazit plný text záznamu

The Immunogenicity and Protective Efficacy of Bovine Herpesvirus 1 Glycoprotein D plus Emulsigen Are Increased by Formulation with CpG Oligodeoxynucleotides

Autor: P. Griebel, Rolf Hecker, S. van Drunen Littel-van den Hurk, X. P. Ioannou, Lorne A. Babiuk

Publikováno v: Journal of Virology. 76:9002-9010

The immunogenicity and protective efficacy of a bovine herpesvirus 1 (BHV-1) subunit vaccine formulated with Emulsigen (Em) and a synthetic oligodeoxynucleotide containing unmethylated CpG dinucleotides (CpG ODN) was determined in cattle. A truncated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::871d073025462d144b16b723b491d4a9
https://doi.org/10.1128/jvi.76.18.9002-9010.2002

Zobrazit plný text záznamu

CpG Motif Identification for Veterinary and Laboratory Species Demonstrates That Sequence Recognition Is Highly Conserved

Autor: Lorne A. Babiuk, Sylvia van Drunen Littel-van den Hurk, Arthur M. Krieg, Robert Rankin, X. P. Ioannou, Reno Pontarollo, Rolf Hecker

Publikováno v: Antisense and Nucleic Acid Drug Development. 11:333-340

Oligodinucleotides containing CpG motifs stimulate vertebrate immune cells in vitro, have proven efficacy in murine disease models and are currently being tested in human clinical trials as therapies for cancer, allergy, and infectious disease. As th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cd3f52e4fd0bca197a416e4ceb78304
https://doi.org/10.1089/108729001753231713

Zobrazit plný text záznamu

Bovine and ovine blood mononuclear leukocytes differ markedly in innate immune responses induced by Class A and Class B CpG-oligodeoxynucleotide

Autor: A. K. Nichani, Yurij Popowych, Angelo Mena, Rolf Hecker, Philip J. Griebel, George Mutwiri, Dale L. Godson, X. P. Ioannou, Lorne A. Babiuk

Publikováno v: Oligonucleotides. 13(4)

Cytosine-phosphate-guanosine (CpG)-DNA can induce an impressive array of innate immune responses that may directly or indirectly contribute to the clearance of infectious agents. Assays, such as lymphocyte proliferative responses, have been used to d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d5a6fd4718f4b80748760d3f0bb3e1a
https://pubmed.ncbi.nlm.nih.gov/15000839

Zobrazit plný text záznamu

Safety and efficacy of CpG-containing oligodeoxynucleotides as immunological adjuvants in rabbits

Autor: X P, Ioannou, S M, Gomis, R, Hecker, L A, Babiuk, S, van Drunen Littel-van den Hurk

Publikováno v: Vaccine. 21(27-30)

The efficacy of oligodeoxynucleotides containing unmethylated CpG dinucleotides (CpG ODN) as an adjuvant for rabbits was assessed alone and in combination with aluminum hydroxide (CpG/alum). The CpG/alum combination elicited a greater immune response

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::295f6c35f06275ee322feb551e914d08
https://pubmed.ncbi.nlm.nih.gov/14505919

Zobrazit plný text záznamu

Biological activity of immunostimulatory CpG DNA motifs in domestic animals

Autor: Hugh G.G. Townsend, Shawn Babiuk, Lorne A. Babiuk, George Mutwiri, Rolf Hecker, S. van Drunen Littel-van den Hurk, X. P. Ioannou, C Tsang, Susantha Gomis, Philip J. Griebel, A Nichani, A. Mena, Reno Pontarollo, Andrew A. Potter, V L Alcón

Publikováno v: Veterinary immunology and immunopathology. 91(2)

Bacterial DNA contains a much higher frequency of CpG dinucleotides than are present in mammalian DNA. Furthermore, bacterial CpG dinucleotides are often not methylated. It is thought that these two features in combination with specific flanking base

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c7d54fb713a2c79bdf83ee7ad273396
https://pubmed.ncbi.nlm.nih.gov/12543546

Zobrazit plný text záznamu

CpG-containing oligodeoxynucleotides, in combination with conventional adjuvants, enhance the magnitude and change the bias of the immune responses to a herpesvirus glycoprotein

Autor: B.C. Karvonen, Susantha Gomis, X. P. Ioannou, Rolf Hecker, Lorne A. Babiuk, S. van Drunen Littel-van den Hurk

Publikováno v: Vaccine. 21(1-2)

Vaccine adjuvants must have the capacity to increase protective immune responses with minimal side effects. Conventional adjuvants not only cause undesirable tissue site reactions, but often induce T-helper type 2 (Th2)-biased responses which may be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b2dffc383963d492a34ebf42c04fa8b
https://pubmed.ncbi.nlm.nih.gov/12443671

Zobrazit plný text záznamu

Th1/Th2 biasing effects of vaccination in cattle as determined by real-time PCR

Autor: Yurij Popowych, Sylvia Van Drunen Little-Van Den Hurk, A. Mena, Andrew G. Van Kessel, Lorne A. Babiuk, Dale L. Godson, X. P. Ioannou

Publikováno v: Journal of immunological methods. 263(1-2)

Real-time polymerase chain reaction (PCR) is now becoming an accepted tool for measuring gene expression at the transcriptional level. In this study, a direct comparison between real-time PCR, enzyme-linked immunosorbent assay (ELISA) and enzyme-link

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5745f34337c940bb7aee01dddf3d9be
https://pubmed.ncbi.nlm.nih.gov/12009200

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání