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Publikováno v:
The Journal of Gene Medicine. 4:498-509
Background The helper-dependent (HD) adenoviral (Ad) vector relies on a helper virus to provide viral proteins for vector amplification. HD-Ad vectors can significantly increase therapeutic gene expression and improve safety. However, the yield of an
Autor:
Heshan Zhou, Tiejun Zhao, X. Mei Rao, Wendy Zheng, Arthur L. Beaudet, Maged F. Nageh, Lucio Pastore
Publikováno v:
Molecular Therapy. 3(4):613-622
Adenoviral vectors are attractive for the delivery of transgenes into mammalian cells because of their efficient transduction, high titer, and stability. The major concerns with using E1-deleted adenoviral vectors in gene therapy are the pathogenic p