Zobrazeno 1 - 10
of 27
pro vyhledávání: '"X. Eric Hu and"'
Autor:
Emmanuela Adjei-Sowah, Yue Peng, Jason Weeks, Jennifer H. Jonason, Karen L. de Mesy Bentley, Elysia Masters, Yugo Morita, Gowrishankar Muthukrishnan, Philip Cherian, X. Eric Hu, Charles E. McKenna, Frank H. Ebetino, Shuting Sun, Edward M. Schwarz, Chao Xie
Publikováno v:
Antibiotics, Vol 10, Iss 6, p 732 (2021)
The use of local antibiotics to treat bone infections has been questioned due to a lack of clinical efficacy and emerging information about Staphylococcus aureus colonization of the osteocyte-lacuno canalicular network (OLCN). Here we propose bisphos
Externí odkaz:
https://doaj.org/article/55d8be3a8e344453a7cad2e4bff9c98b
Autor:
Edward M. Schwarz, Shuting Sun, Karen L. de Mesy Bentley, X. Eric Hu, Chao Xie, Jennifer H. Jonason, Emmanuela Adjei-Sowah, Yue Peng, Elysia A Masters, Gowrishankar Muthukrishnan, Charles E. McKenna, Frank H. Ebetino, Yugo Morita, Philip T. Cherian, Jason Weeks
Publikováno v:
Antibiotics, Vol 10, Iss 732, p 732 (2021)
Antibiotics
Volume 10
Issue 6
Antibiotics
Volume 10
Issue 6
The use of local antibiotics to treat bone infections has been questioned due to a lack of clinical efficacy and emerging information about Staphylococcus aureus colonization of the osteocyte-lacuno canalicular network (OLCN). Here we propose bisphos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd07af541f011ac4ec3698dd0963e209
https://pubmed.ncbi.nlm.nih.gov/34204351
https://pubmed.ncbi.nlm.nih.gov/34204351
Autor:
Zhiqian Dong, William L. Seibel, Ruben Papoian, Sreenivasa R. Mundla, X. Eric Hu, Marcin Golczak, Krzysztof Palczewski, Jianye Zhang
Publikováno v:
Molecular Pharmacology. 87:477-491
All-trans-retinal, a retinoid metabolite naturally produced upon photoreceptor light activation, is cytotoxic when present at elevated levels in the retina. To lower its toxicity, two experimentally validated methods have been developed involving inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f28c300f460acc512ac243eff13f109
https://doi.org/10.1124/mol.114.096560
https://doi.org/10.1124/mol.114.096560
Autor:
Ofer Reizes, Anny Odile Colson, José Méndez-Andino, Kenneth M. Meyers, Jennifer L. Paris, Karen M.B. Hodge, John August Wos, X. Eric Hu, Jeremy M. Howard, Cindy Obringer, Maria C. Mitchell, Martin E. Dowty
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:657-661
The synthesis and biological testing of novel classes of potent melanin-concentrating hormone (MCH-R1) antagonists based on pyrazolopiperazinone and pyrrolopiperazinone scaffolds are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b63c13330f72f8b408838e3e9d397233
https://doi.org/10.1016/j.bmcl.2006.10.096
https://doi.org/10.1016/j.bmcl.2006.10.096
Autor:
Namal Chithranga Warshakoon, Beth B. Pinney, Ofer Reizes, Nick K. Kim, Justin Sheville, Chrissy Mitchell, José Méndez-Andino, X. Eric Hu, Jennifer L. Paris, John August Wos, Ritu Tiku Bhatt, Wei Ji, Kenneth M. Meyers
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:5207-5211
A novel series of substituted quinoline analogs were designed and synthesized as potent and selective melanin concentrating hormone (MCH) antagonists. These analogs show potent (nM) activity (12a-k) with a moderate selectivity. Conversely, the confor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f63414ec00add49c8dc48a46f38fcb17
https://doi.org/10.1016/j.bmcl.2006.07.006
https://doi.org/10.1016/j.bmcl.2006.07.006
Autor:
Leo Grinius, Nick K. Kim, Glen E. Mieling, Charles M. Morris, Thomas P. Demuth, X. Eric Hu, Cynthia D. Wallace
Publikováno v:
Synthesis. 2003:1732-1738
(5S)-Tricyclic penems were synthesized for the first time via intramolecular cyclization of penem epoxy amides catalyzed by a weak Lewis acid [Mg(ClO 4 ) 2 ]. Due to the high degree of ring strain in these molecules, mild reaction conditions were dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cefb686654910e27f26541476cd5456e
https://doi.org/10.1055/s-2003-40882
https://doi.org/10.1055/s-2003-40882
Autor:
Ji-In Kim Almstead, Nick K. Kim, Jeffrey Lyle Gray, X. Eric Hu, William L. Seibel, Benoit Ledoussal
Publikováno v:
Journal of Medicinal Chemistry. 46:3655-3661
Novel quinolone antibacterial agents bearing (3S)-amino-(4R)-ethylpiperidines were designed by using low energy conformation analysis and synthesized by applying a conventional coupling reaction of the quinolone nuclei with new piperidine side chains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37b7f93f841ff8ce53c3eeee5f803dce
https://doi.org/10.1021/jm030272n
https://doi.org/10.1021/jm030272n
Publikováno v:
Tetrahedron Letters. 43:4289-4293
3,4-Piperidinyl aziridine N-phosphonate underwent ring opening in Grignard addition catalyzed by a copper reagent to yield trans 3-amino-4-alkyl-piperidines. The nucleophilic addition occurred trans to the aziridine group and regioselectively at C-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e30ea96b7a2a75414cdb7c6ea06fbad1
https://doi.org/10.1016/s0040-4039(02)00639-1
https://doi.org/10.1016/s0040-4039(02)00639-1
Publikováno v:
Journal of Organometallic Chemistry. 646:212-222
Asymmetric Michael reaction of phosphinic or aminophosphinic acids with acrylate derivatives afforded phosphinyl dipeptidomimetics in excellent yields (>90%). Chiral induction of substituents at the α-position of acrylate derivatives of Evans oxazol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2aa3d2b878addaa014c59f6d78429dc
https://doi.org/10.1016/s0022-328x(01)01388-2
https://doi.org/10.1016/s0022-328x(01)01388-2
Autor:
Thomas P. Demuth, X. Eric Hu and
Publikováno v:
The Journal of Organic Chemistry. 63:1719-1723
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bad99bfb3cb7b7471682def61c4a45fe
https://doi.org/10.1021/jo9716845
https://doi.org/10.1021/jo9716845