Zobrazeno 1 - 10
of 176
pro vyhledávání: '"X. Emonds-Alt"'
Autor:
Soazig Nénan, Vincent Lagente, M Veron, X Emonds-Alt, Elisabeth Boichot, Charles Advenier, Isabelle Guenon
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 31:634-640
1. Several observations suggest that tachykinins are involved in the pathogenesis of bronchopulmonary alterations. We have investigated the effect of antagonists for tachykinin NK1 (SR 140333), NK2 (SR 48968) or NK3 (SR 142801) receptors on inflammat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb6f3b4923c7f6d12e7d1116d17e72e0
https://doi.org/10.1111/j.1440-1681.2004.04061.x
https://doi.org/10.1111/j.1440-1681.2004.04061.x
Publikováno v:
European Respiratory Journal. 20:268-273
Gastro-oesophageal reflux is a common clinical disorder associated with a variety of respiratory symptoms, including chronic cough and exacerbation of asthma. In this study, the potential role of acid-induced tachykinin release was examined in guinea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fd26765ec50cad755671d258106d0f1
https://doi.org/10.1183/09031936.02.00250902
https://doi.org/10.1183/09031936.02.00250902
Publikováno v:
Revue Française d'Allergologie et d'Immunologie Clinique. 38:963-971
Resume Il est maintenant acquis que les tachykinines du systeme NANC excitateur jouent un role important au niveau des voies aeriennes. Elles induisent une bronchoconstriction par l'activation du recepteur NK 2 , elles provoquent une augmentation de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49706eeb948c688234a20f0882234765
https://doi.org/10.1016/s0335-7457(98)80173-1
https://doi.org/10.1016/s0335-7457(98)80173-1
Publikováno v:
Clinical & Experimental Allergy. 28:1299-1305
Background Tachykinins, such as substance P, might be involved in the development of airway hyperresponsiveness and airway inflammation. Objective This study was designed to investigate the effects of the tachykinin NK1 receptor antagonist SR 140333
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a89e0f6cac62b6cfd5aa33d992ed25e9
https://doi.org/10.1046/j.1365-2222.1998.00398.x
https://doi.org/10.1046/j.1365-2222.1998.00398.x
Autor:
G. Le Fur, S Daoul, J.C. Brelière, D. Van Broeck, M. Poncelet, Charles Advenier, Jean-Philippe Ducoux, Marco Landi, Emmanuel Naline, C Cognon, Philippe Soubrie, Vincenzo Proietto, X. Emonds-Alt, P. Vilain, Gervais Neliat, J P Maffrand, T. Croci
Publikováno v:
Neuropeptides. 31:449-458
(R)-3-(1-[2-(4-benzoyl-2-(3,4-difluorophenyl)-morpholin-2-yl)- ethyl]-4-phenylpiperidin-4-yl)-1-dimethylurea (SR 144190) is a new non-peptide antagonist of tachykinin NK2 receptors. SR 144190 potently and selectively inhibited neurokinin A binding to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635453df0e79e08dfa3ea9112dc64bd6
https://doi.org/10.1016/s0143-4179(97)90039-1
https://doi.org/10.1016/s0143-4179(97)90039-1
Publikováno v:
European Respiratory Journal. 9:1445-1450
Tachykinins, such as substance P, might be involved in the development of airway hyperresponsiveness (AHR) and airway inflammation. However, it is unknown which tachykinin receptors mediate these biological activities. The effects of two antagonists
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e286fe89c111eebd7b18adc2de4d42c
https://doi.org/10.1183/09031936.96.09071445
https://doi.org/10.1183/09031936.96.09071445
Autor:
Daniel Bichon, B. Miloux, M. Poncelet, J.C. Brele`ere, Gervais Neliat, X. Emonds-Alt, Jean-Philippe Ducoux, Vincenzo Proietto, P. Vilain, D. Van Broeck, Michel Heaulme, Philippe Soubrie, G. Le Fur
Publikováno v:
Life Sciences. 56:PL27-PL32
SR 142801 is the first potent and selective non-peptide antagonist of the tachykinin NK3 receptor. It inhibited [MePhe7]NKB binding to its receptor from various species, including humans. SR 142801 was a competitive antagonist of [MePhe7]NKB-mediated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00cba3ece7eda5bf9198e2c8b7ed1fc4
https://doi.org/10.1016/0024-3205(94)00413-m
https://doi.org/10.1016/0024-3205(94)00413-m
Autor:
J. Souilhac, J.C. Brelière, R. Calassi, X. Emonds-Alt, Philippe Soubrie, G. Le Fur, Jeanne Maruani, Christiane Gueudet, M. Jung, M. Poncelet, M.C. Barnouin
Publikováno v:
Neuropharmacology. 33:167-179
SR 140333 (1-2-[3-(3,4-dichlorophenyl)-1-(3-isopropoxyphenylacetyl)piperidin-3-yl]ethyl-4-phenyl -1-azonia-bicyclo[2.2.2]octane, chloride), a potent non peptide ligand of the substance P (SP) NK1 receptor subtype with high affinity for NK1 receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea20ebd19d0a5d2461d7350605796cf5
https://doi.org/10.1016/0028-3908(94)90004-3
https://doi.org/10.1016/0028-3908(94)90004-3
Publikováno v:
Pulmonary Pharmacology. 6:63-67
The aim of this study was to demonstrate the involvement of neuropeptides in the increase in microvascular permeability induced by bradykinin in guinea-pig airways in vivo and to determine the type of receptor involved. Extravasation of intravenously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c12af9801a63793ffb399bedfa34acf
https://doi.org/10.1006/pulp.1993.1009
https://doi.org/10.1006/pulp.1993.1009
Autor:
Nguyen Qt, Regoli D, Emmanuel Naline, J.C. Brelière, X. Emonds-Alt, Charles Advenier, Rouissi N, Neliat G
Publikováno v:
Biochemical and Biophysical Research Communications. 184:1418-1424
SR 48968, a new non-peptide antagonist of NK 2 receptors, has been tested in a variety of isolated smooth muscle preparations from rats, guinea pigs, rabbits, hamsters and men, in order to assess its selectivity for NK 2 receptors as well as its comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29b6493a619565fec27bbe8e7e9f9737
https://doi.org/10.1016/s0006-291x(05)80041-5
https://doi.org/10.1016/s0006-291x(05)80041-5