Zobrazeno 1 - 10
of 221
pro vyhledávání: '"X Long, Zheng"'
Publikováno v:
Cerebrovascular Diseases Extra, Vol 11, Iss 1, Pp 29-36 (2021)
Background: Thrombotic thrombocytopenic purpura (TTP) is a rare blood disorder resulting in organ damage including ischemic strokes. We sought to characterize the neuroimaging patterns of stroke in a large cohort of patients with immune-mediated TTP
Externí odkaz:
https://doaj.org/article/250eae03eed84d6b802a781523bbb0a7
Autor:
Jingrui Sui, Wenjing Cao, Konstantine Halkidis, Mohammad S. Abdelgawwad, Nicole K. Kocher, Bryan Guillory, Lance A. Williams, Radhika Gangaraju, Marisa B. Marques, X. Long Zheng
Publikováno v:
Blood Advances, Vol 3, Iss 24, Pp 4177-4186 (2019)
Abstract: Immune thrombotic thrombocytopenic purpura (iTTP) is primarily caused by immunoglobulin G (IgG)–type autoantibodies that bind and inhibit plasma ADAMTS13 activity and/or accelerate its clearance from circulation. Approximately 50% of pati
Externí odkaz:
https://doaj.org/article/3075a9848ea04a87aa80ea5d219f1fe4
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 5, Iss 6, Pp n/a-n/a (2021)
Abstract Background Heparin‐induced thrombocytopenia (HIT) is a life‐threatening thrombotic complication after heparin exposure. However, the role of ADAMTS‐13 and von Willebrand factor (VWF) in the disease process and outcomes of HIT is not kn
Externí odkaz:
https://doaj.org/article/685fc3bcc5ec4a9a9eb401275c5d9e15
Publikováno v:
TH Open, Vol 05, Iss 01, Pp e1-e7 (2021)
Background Neurological involvement is common in patients with immune thrombotic thrombocytopenic purpura (iTTP), but the frequency, risk factors, and outcomes of these with imaging-confirmed stroke in iTTP are not known. Methods We selected 66 out o
Externí odkaz:
https://doaj.org/article/2bd1a15292c149f0ac4bc8cc8930d935
Autor:
Liang Zheng, Mohammad S. Abdelgawwad, Di Zhang, Leimeng Xu, Shi Wei, Wenjing Cao, X. Long Zheng
Publikováno v:
Haematologica, Vol 105, Iss 4 (2020)
Thrombotic thrombocytopenic purpura (TTP) is caused by severe deficiency of ADAMTS13 (A13), a plasma metalloprotease that cleaves endothelium-derived von Willebrand factor (VWF). However, severe A13 deficiency alone is often not sufficient to cause a
Externí odkaz:
https://doaj.org/article/c99fbb0d3c3342cdac7355f8667a3e73
Publikováno v:
Journal of Thrombosis and Haemostasis. 20:2270-2283
Severe deficiency of plasma ADAMTS13 activity may result in potentially fatal thrombotic thrombocytopenic purpura and relative deficiency of plasma ADAMTS13 activity may be associated with adverse outcomes of certain malignancies. Here, we report the
Autor:
Shruti, Chaturvedi, Ana G, Antun, Andrew M, Farland, Ryan, Woods, Ara, Metjian, Yara A, Park, Gustaaf, de Ridder, Briana, Gibson, Raj S, Kasthuri, Darla K, Liles, Frank, Akwaa, Todd, Clover, Lisa, Baumann Kreuziger, J Evan, Sadler, Meera, Sridharan, Ronald S, Go, Keith R, McCrae, Harsh Vardhan, Upreti, Angela, Liu, Ming Y, Lim, Radhika, Gangaraju, X Long, Zheng, Jay S, Raval, Camila, Masias, Spero R, Cataland, Andrew, Johnson, Elizabeth, Davis, Michael D, Evans, Marshall A, Mazepa
Publikováno v:
Blood. 140:1335-1344
Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is characterized by recurring episodes of thrombotic microangiopathy, causing ischemic organ impairment. Black patients are overrepresented in iTTP cohorts in the United States, but racial di
Autor:
Liang Zheng, Yingying Mao, Mohammad S. Abdelgawwad, Nicole K. Kocher, Mandy Li, Xiangrong Dai, Benjamin Li, X. Long Zheng
Publikováno v:
Blood Advances, Vol 1, Iss 1, Pp 75-83 (2016)
Abstract: Thrombotic thrombocytopenic purpura (TTP), a potentially fatal blood clot disorder, is primarily caused by severe deficiency of plasma ADAMTS13 activity resulting from acquired autoantibodies. Plasma exchange is the only effective initial t
Externí odkaz:
https://doaj.org/article/34c526799c7b469d8a77d8247241821c
Autor:
Elizabeth M. Staley, Wenjing Cao, Huy P. Pham, Chong H. Kim, Nicole K. Kocher, Lucy Zheng, Radhika Gangaraju, Robin G. Lorenz, Lance A. Williams, Marisa B. Marques, X. Long Zheng
Publikováno v:
Haematologica, Vol 104, Iss 1 (2019)
Immune-mediated thrombotic thrombocytopenic purpura is characterized by severe thrombocytopenia and microangiopathic hemolytic anemia. It is primarily caused by immunoglobin G type autoantibodies against ADAMTS13, a plasma metalloprotease that cleave
Externí odkaz:
https://doaj.org/article/7b5f965436604a24acbac6b211ff1ace
Publikováno v:
Blood.
Antibody binding to a plasma metalloprotease ADAMTS13 is necessary for the development of immune thrombotic thrombocytopenic purpura (iTTP). Inhibition of ADAMTS13-mediated VWF cleavage by such antibodies clearly plays a role in the pathophysiology o