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Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 309:E632-E639
In rat pancreatic islets, β-cell gene expression, survival, and subsequent acute glucose stimulation of insulin secretion (GSIS) are optimally preserved by prolonged culture at 10 mM glucose (G10) and markedly altered by culture at G5 or G30. Here,