Zobrazeno 1 - 10
of 24 767
pro vyhledávání: '"X - ray Structure"'
Autor:
Daniele Veggi, Chelsy C. Chesterman, Laura Santini, Ying Huang, Nicola Pacchiani, Jeannette Sierra, Lynn Chen, Jason Laliberte, Federica Bianchi, Roberta Cozzi, Elisabetta Frigimelica, Domenico Maione, Oretta Finco, Matthew J. Bottomley
Publikováno v:
FASEB BioAdvances, Vol 6, Iss 8, Pp 235-248 (2024)
Abstract Thousands of disease cases and hundreds of deaths occur globally each year due to invasive meningococcal disease. Neisseria meningitidis serogroup B (MenB) is the leading cause of such disease in developed countries. Two vaccines, 4CMenB and
Externí odkaz:
https://doaj.org/article/9b599c9365e449dfb0b143e66a3cfe14
Autor:
Marta Ilona Wojtyś, Weronika Maksymiuk, Marta Narczyk, Ante Bubić, Ivana Leščić Ašler, Paweł Krzyżek, Grażyna Gościniak, Elżbieta Katarzyna Jagusztyn-Krynicka, Agnieszka Bzowska
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
The current therapies against gastric pathogen Helicobacter pylori are ineffective in over 20% of patients. Enzymes belonging to the purine salvage pathway are considered as novel drug targets in this pathogen. Therefore, the main aim of the current
Externí odkaz:
https://doaj.org/article/d49a28023d5d4282a32dff07929d534e
Autor:
Mohamed El-Naggar, Kamrul Hasan, Monther A. Khanfar, Fatima-Azzahra Delmani, Ihsan A. Shehadi, Raed Al-Qawasmeh, Hussein M. Elmehdi
Publikováno v:
Heliyon, Vol 10, Iss 22, Pp e40318- (2024)
Triazole is considered as a privileged scaffold in medicinal chemistry by virtue of it is diverse biological activity. several drugs currently in the market possess triazole moiety. In this study click chemistry was performed on the pyridine based 1,
Externí odkaz:
https://doaj.org/article/ce14e4065d5a46d08da53c36ec6028c8
Publikováno v:
Molbank, Vol 2024, Iss 3, p M1878 (2024)
The title compound and its hydroxymethyl precursor have been fully characterised for the first time. The IR spectra, fully assigned 1H and 13C NMR spectra, and X-ray structures are presented for both compounds. Both compounds form hydrogen-bonded dim
Externí odkaz:
https://doaj.org/article/6a204a415e464552ac79072bacb8edc9
Publikováno v:
Advanced Science, Vol 11, Iss 30, Pp n/a-n/a (2024)
Abstract The N─Oxide oxygen in the 111 C─I···⁻O─N+ halogen bond (XB) complexes, formed by five perfluoroiodobenzene XB donors and 32 pyridine N‐oxides (PyNO) XB acceptors, exhibits three XB modes: bidentate, tridentate, and monodentate.
Externí odkaz:
https://doaj.org/article/6d355d713bdc4c0ebdac92f8f8ec0289
Publikováno v:
Molbank, Vol 2024, Iss 3, p M1860 (2024)
The hydrovinylation of nopadiene gave a single 1,4-addition product (1) as an oil. A 3- step transformation of 3 gave 2,4-dinitrophenylhydrazone 6 as a crystalline compound. X-ray diffraction analysis of 6 confirmed the stereochemical assignments abo
Externí odkaz:
https://doaj.org/article/05e8e8ad8893493e847558f8e7f92415
Autor:
El-Naggar, Mohamed a, ⁎, Hasan, Kamrul a, Khanfar, Monther A. a, b, Delmani, Fatima-Azzahra c, Shehadi, Ihsan A. a, Al-Qawasmeh, Raed a, b, Elmehdi, Hussein M. d
Publikováno v:
In Heliyon 30 November 2024 10(22)
Autor:
R. Alan Aitken, Khadija Ait Moulay, David B. Cordes, Ryan A. Inwood, Fraser G. Jamieson, Alexander J. B. Nelson, Aidan P. McKay
Publikováno v:
Organics, Vol 5, Iss 1, Pp 12-31 (2024)
A series of fourteen O-ethyl-N-butylphenylphosphonamidates with benzyl ether substituents at the ortho position was prepared and fully characterised. Upon treatment with n-butyllithium in THF at RT, they underwent cyclisation in eight cases to give t
Externí odkaz:
https://doaj.org/article/7bb160c7549e4946872a87e08bc3ca0e
Publikováno v:
Molbank, Vol 2024, Iss 2, p M1835 (2024)
(S)-1-Methyl-2-oxoimidazolidine-4-carboxylic acid 1 is an analog of (S)-pyroglutamic acid, a key component of naturally occurring peptide hormones and synthetic pharmaceutical candidates. The reaction of (S)-2-amino-3-(methylamino)propionic acid with
Externí odkaz:
https://doaj.org/article/5d2cba90480e4b52a612fdc9fe0a084a
Publikováno v:
Molbank, Vol 2024, Iss 2, p M1803 (2024)
A simplified synthesis of the title compound is reported and its 1H and 13C NMR data are fully assigned including determination of H–H and C–H coupling constants. Its X-ray structure has been determined for the first time. NMR data are also prese
Externí odkaz:
https://doaj.org/article/2b22e912fac64ecb8453224ff48d28f7