Zobrazeno 1 - 10
of 59
pro vyhledávání: '"X, Nair"'
Publikováno v:
Mediators of Inflammation, Vol 3, Iss 6, Pp 459-463 (1994)
The anti-inflammatory effect of a small molecular weight antagonist of P- and E-selectin-dependent cell adhesion was examined. The glycolipid sulphatide was shown to block the adherence of thrombin-activated rat platelets to HL-60 cells. This interac
Externí odkaz:
https://doaj.org/article/f9b43aa2b7424085b095a04bd32f6595
Autor:
A, Marinier, A, Martel, C, Bachand, S, Plamondon, B, Turmel, J P, Daris, J, Banville, P, Lapointe, C, Ouellet, P, Dextraze, M, Menard, J J, Wright, J, Alford, D, Lee, P, Stanley, X, Nair, G, Todderud, K M, Tramposch
Publikováno v:
Bioorganicmedicinal chemistry. 9(6)
A series of potent inhibitors of P-selectin as potential anti-inflammatory agents is reported. These compounds are derivatives of galactocerebrosides bearing a malonate side chain in positions 2 and 3 of the galactose moiety. Based on the binding mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d4bfa241f491c81ae323a51a6f8272a4
https://pubmed.ncbi.nlm.nih.gov/11408160
https://pubmed.ncbi.nlm.nih.gov/11408160
Autor:
G, Todderud, X, Nair, D, Lee, J, Alford, L, Davern, P, Stanley, C, Bachand, P, Lapointe, A, Marinier, A, Martel, M, Menard, J J, Wright, J, Bajorath, D, Hollenbaugh, A, Aruffo, K M, Tramposch
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 282(3)
Selectin binding is the first step in extravasation of leukocytes through the endothelium. Infiltration of leukocytes is a hallmark of an inflammatory response. Blockade of selectin-dependent adhesion, therefore, represents a specific mechanism-based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a552d744acf41957aed1fe677c86798d
https://pubmed.ncbi.nlm.nih.gov/9316838
https://pubmed.ncbi.nlm.nih.gov/9316838
Autor:
A H, Lewin, S L, Black, M E, Bos, R R, Goehring, X, Nair, G, Whiting, P, Bouquin, G, Tetrault, F I, Carroll
Publikováno v:
Pharmaceutical research. 12(7)
Optimization of the therapeutic ratio of analogs of the topically active 11-cis, 13-cis-12-hydroxymethylretinoic acid, delta-lactone (1) relative to antihyperproliferation and antihyperkeratinization vs. toxicity.Nine analogs of 1, in which variation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::384e8672721eeabdfe8bee3b6381fee1
https://pubmed.ncbi.nlm.nih.gov/7494818
https://pubmed.ncbi.nlm.nih.gov/7494818
Autor:
A H, Lewin, R R, Goehring, F C, Zusi, G J, Gendimenico, X, Nair, G, Whitting, P, Bouquin, G, Tetrault, F I, Carroll
Publikováno v:
Pharmaceutical research. 11(7)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::603e813e5a252d4f345bed4177e916cd
https://pubmed.ncbi.nlm.nih.gov/7937550
https://pubmed.ncbi.nlm.nih.gov/7937550
Publikováno v:
Pharmaceutical research. 11(2)
Evaluation of 13-cis-12-substituted analogues of retinoic acid in a series of dermatologic screens has revealed that structural modifications can lead to selectivity and specificity. An analogue, 11-cis,13-cis-12-hydroxymethylretinoic acid, delta-lac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b31ab4635aa8374204ec1efaa602a347
https://pubmed.ncbi.nlm.nih.gov/8165176
https://pubmed.ncbi.nlm.nih.gov/8165176
Publikováno v:
Inflammation. 17(2)
A predictive animal model of skin inflammation is needed for the development of potential therapeutic agents. The existing models of inflammation rely on animals whose skin physiology or biochemistry differs significantly from human. The objective of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fce74f935beb950d49de4adf8b1a8447
https://pubmed.ncbi.nlm.nih.gov/8491515
https://pubmed.ncbi.nlm.nih.gov/8491515
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 256(1)
In the treatment of various dermatological disorders, topically applied retinoids have potential therapeutic use with the advantage of improved localized activity and lower toxicity over systemically administered retinoids. However, most retinoids ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d0aa2a47dff88cae48a20f65833f2573
https://pubmed.ncbi.nlm.nih.gov/1988666
https://pubmed.ncbi.nlm.nih.gov/1988666
Autor:
X, Nair
Publikováno v:
Research communications in chemical pathology and pharmacology. 9(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0df7c5e7a5bc50e9f50097fb9a30759d
https://pubmed.ncbi.nlm.nih.gov/4445570
https://pubmed.ncbi.nlm.nih.gov/4445570
Publikováno v:
The Journal of investigative dermatology. 93(3)
We investigated the effects of the retinoids, all-trans retinoic acid (t-RA), 13-cis retinoic acid, etretinate, and arotinoid ethyl ester, on 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced DNA synthesis, and epidermal hyperplasia in hairless mou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6a64bd7ae7341ff24f8c8262084a83d3
https://pubmed.ncbi.nlm.nih.gov/2768837
https://pubmed.ncbi.nlm.nih.gov/2768837