Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Wytze J Vlietstra"'
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0271395 (2022)
Genome-wide association studies (GWAS) have identified many single nucleotide polymorphisms (SNPs) that play important roles in the genetic heritability of traits and diseases. With most of these SNPs located on the non-coding part of the genome, it
Externí odkaz:
https://doaj.org/article/d18d178dca1f432fbd5e8da5b393e046
Publikováno v:
Journal of Biomedical Semantics, Vol 11, Iss 1, Pp 1-11 (2020)
Abstract Background Knowledge graphs can represent the contents of biomedical literature and databases as subject-predicate-object triples, thereby enabling comprehensive analyses that identify e.g. relationships between diseases. Some diseases are o
Externí odkaz:
https://doaj.org/article/a8f13915053546b5b20c6827ab2d876e
Publikováno v:
Journal of Biomedical Semantics, Vol 9, Iss 1, Pp 1-10 (2018)
Abstract Background Biomedical knowledge graphs have become important tools to computationally analyse the comprehensive body of biomedical knowledge. They represent knowledge as subject-predicate-object triples, in which the predicate indicates the
Externí odkaz:
https://doaj.org/article/2e8e6e8eef204dd1a4a834b4091c4343
Autor:
Sanne J. van der Veen, Wytze J. Vlietstra, Laura van Dussen, André B.P. van Kuilenburg, Marcel G. W. Dijkgraaf, Malte Lenders, Eva Brand, Christoph Wanner, Derralynn Hughes, Perry M. Elliott, Carla E. M. Hollak, Mirjam Langeveld
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 16, p 5784 (2020)
Fabry Disease (FD) is a rare, X-linked, lysosomal storage disease that mainly causes renal, cardiac and cerebral complications. Enzyme replacement therapy (ERT) with recombinant alpha-galactosidase A is available, but approximately 50% of male patien
Externí odkaz:
https://doaj.org/article/6bb61548db1441af83b377edf9e1fac9
Autor:
Carla E. M. Hollak, Sanne J. van der Veen, Christoph Wanner, Laura van Dussen, André B.P. van Kuilenburg, Eva Brand, Malte Lenders, Marcel G. W. Dijkgraaf, Perry M. Elliott, Derralynn Hughes, Wytze J. Vlietstra, Mirjam Langeveld
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, 21(16):5784. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, Vol 21, Iss 5784, p 5784 (2020)
International journal of molecular sciences, 21(16):5784. Multidisciplinary Digital Publishing Institute (MDPI)
Volume 21
Issue 16
International Journal of Molecular Sciences, 21(16):5784. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, Vol 21, Iss 5784, p 5784 (2020)
International journal of molecular sciences, 21(16):5784. Multidisciplinary Digital Publishing Institute (MDPI)
Volume 21
Issue 16
Fabry Disease (FD) is a rare, X-linked, lysosomal storage disease that mainly causes renal, cardiac and cerebral complications. Enzyme replacement therapy (ERT) with recombinant alpha-galactosidase A is available, but approximately 50% of male patien
Publikováno v:
Journal of biomedical semantics, 11(1):9. BioMed Central Ltd
Journal of Biomedical Semantics
Journal of Biomedical Semantics, Vol 11, Iss 1, Pp 1-11 (2020)
Journal of Biomedical Semantics, 11(1):9. BioMed Central Ltd.
Journal of Biomedical Semantics
Journal of Biomedical Semantics, Vol 11, Iss 1, Pp 1-11 (2020)
Journal of Biomedical Semantics, 11(1):9. BioMed Central Ltd.
Background Knowledge graphs can represent the contents of biomedical literature and databases as subject-predicate-object triples, thereby enabling comprehensive analyses that identify e.g. relationships between diseases. Some diseases are often diag
Autor:
Erik M. van Mulligen, Jan A. Kors, Erik Anthony Schultes, Floris Wiesman, Ronald Zielman, Robin M. van Dongen, Wytze J. Vlietstra, Rein Vos
Publikováno v:
Journal of Biomedical Informatics, 71, 178-189. Elsevier Science
Journal of Biomedical Informatics, 71, 178-189. Academic Press
Journal of Biomedical Informatics, 71, 178-189. Academic Press
Problem: Biomedical literature and databases contain important clues for the identification of potential disease biomarkers. However, searching these enormous knowledge reservoirs and integrating findings across heterogeneous sources is costly and di
Autor:
Dorien J.M. Peters, Peter A C 't Hoen, Wytze J. Vlietstra, Roman Kudrin, Kristina Hettne, Sergey S. Starikov, Rein Vos, Erik M. van Mulligen, Mohammed Charrout, Tareq B. Malas, Jan A. Kors, Marco Roos
Publikováno v:
Scientific Reports, 9:6281. Nature Publishing Group
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports, 9
Scientific Reports, 9. NATURE PUBLISHING GROUP
Scientific Data, 9(1), 6281. Springer Nature
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports, 9
Scientific Reports, 9. NATURE PUBLISHING GROUP
Scientific Data, 9(1), 6281. Springer Nature
Scientific Reports
Compounds that are candidates for drug repurposing can be ranked by leveraging knowledge available in the biomedical literature and databases. This knowledge, spread across a variety of sources, can be integrated within a knowledge graph, which there
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::497965ea7478fda8f0a8a30e1d248bd2
https://pure.eur.nl/en/publications/c441421e-1db5-45d6-92fe-e994f0290dd9
https://pure.eur.nl/en/publications/c441421e-1db5-45d6-92fe-e994f0290dd9
Autor:
Umesh K. Nandal, Perry D. Moerland, Antoine H. C. van Kampen, Dave Speijer, Carsten Byrman, Wytze J. Vlietstra, Jeffrey H. Ringrose, Rienk E. Jeeninga
Publikováno v:
BMC bioinformatics, 16(1). BioMed Central
Nandal, U K, Vlietstra, W J, Byrman, C, Jeeninga, R E, Ringrose, J H, van Kampen, A H C, Speijer, D & Moerland, P D 2015, ' Candidate prioritization for low-abundant differentially expressed proteins in 2D-DIGE datasets ', BMC Bioinformatics . https://doi.org/10.1186/s12859-015-0455-x
BMC Bioinformatics, 16:25. BioMed Central
BMC Bioinformatics. BioMed Central
BMC Bioinformatics
Nandal, U K, Vlietstra, W J, Byrman, C, Jeeninga, R E, Ringrose, J H, van Kampen, A H C, Speijer, D & Moerland, P D 2015, ' Candidate prioritization for low-abundant differentially expressed proteins in 2D-DIGE datasets ', BMC Bioinformatics . https://doi.org/10.1186/s12859-015-0455-x
BMC Bioinformatics, 16:25. BioMed Central
BMC Bioinformatics. BioMed Central
BMC Bioinformatics
Background Two-dimensional differential gel electrophoresis (2D-DIGE) provides a powerful technique to separate proteins on their isoelectric point and apparent molecular mass and quantify changes in protein expression. Abundantly available proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b21fc8a41ca825172eba93647fdc4af3
https://pure.amc.nl/en/publications/candidate-prioritization-for-lowabundant-differentially-expressed-proteins-in-2ddige-datasets(2b02d983-24bb-4ea4-9cc1-a7131a66a3cb).html
https://pure.amc.nl/en/publications/candidate-prioritization-for-lowabundant-differentially-expressed-proteins-in-2ddige-datasets(2b02d983-24bb-4ea4-9cc1-a7131a66a3cb).html
Autor:
Jeffrey H. Ringrose, Perry D. Moerland, Ben Berkhout, Gert Jan Kramer, Rienk E. Jeeninga, Carsten Byrman, Wytze J. Vlietstra, Dave Speijer
Publikováno v:
Frontiers in Microbiology. Frontiers Media S.A.
Frontiers in Microbiology, Vol 3 (2012)
Frontiers in Microbiology
Kramer, G, Moerland, P D, Jeeninga, R E, Vlietstra, W J, Ringrose, J H, Byrman, C, Berkhout, B & Speijer, D 2012, ' Proteomic analysis of HIV–T cell interaction: an update ', Frontiers in Microbiology . https://doi.org/10.3389/fmicb.2012.00240
Frontiers in Microbiology, Vol 3 (2012)
Frontiers in Microbiology
Kramer, G, Moerland, P D, Jeeninga, R E, Vlietstra, W J, Ringrose, J H, Byrman, C, Berkhout, B & Speijer, D 2012, ' Proteomic analysis of HIV–T cell interaction: an update ', Frontiers in Microbiology . https://doi.org/10.3389/fmicb.2012.00240
This mini-review summarizes techniques applied in, and results obtained with, proteomic studies of human immunodeficiency virus type 1 (HIV-1)-T cell interaction. Our group previously reported on the use of two-dimensional differential gel electropho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91cf6187c72d87e51873a6d687f0659e
https://research.vu.nl/en/publications/795e217d-2cd7-4c7a-b94d-fb3c6c26cb70
https://research.vu.nl/en/publications/795e217d-2cd7-4c7a-b94d-fb3c6c26cb70