Zobrazeno 1 - 10
of 207
pro vyhledávání: '"Wytse J. Wadman"'
Autor:
Erine Craey, Fabian Hulpia, Jeroen Spanoghe, Simona Manzella, Lars E. Larsen, Mathieu Sprengers, Dimitri De Bundel, Ilse Smolders, Evelien Carrette, Jean Delbeke, Kristl Vonck, Paul Boon, Serge Van Calenbergh, Wytse J. Wadman, Robrecht Raedt
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 16, p 8887 (2022)
We report the design, synthesis, and validation of the novel compound photocaged N6-cyclopentyladenosine (cCPA) to achieve precisely localized and timed release of the parent adenosine A1 receptor agonist CPA using 405 nm light. Gi protein-coupled A1
Externí odkaz:
https://doaj.org/article/ebe67bf7ff904601a50d9497aa46580a
Publikováno v:
Frontiers in Computational Neuroscience, Vol 14 (2020)
Neurons in many brain regions exhibit spontaneous, intrinsic rhythmic firing activity. This rhythmic firing activity may determine the way in which these neurons respond to extrinsic synaptic inputs. We hypothesized that neurons should be most respon
Externí odkaz:
https://doaj.org/article/f82a3c0d51bd4a0c90a503c065302987
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Abstract The mechanical properties of brain tissue play a pivotal role in neurodevelopment and neurological disorders. Yet, at present, there is no consensus on how the different structural parts of the tissue contribute to its stiffness variations.
Externí odkaz:
https://doaj.org/article/5b22ffeb4a2d4bfb8160c64fa840b73a
Publikováno v:
Frontiers in Integrative Neuroscience, Vol 13 (2019)
Micro Electrode Arrays were used to simultaneously record spontaneous extracellular action potentials from 10 to 30 dopamine neurons in acute brain slices from the lateral Ventral Tegmental Area (VTA) of the rat. The spike train of an individual neur
Externí odkaz:
https://doaj.org/article/18c83ed6a9ce41b7a019f075f10b78f2
Publikováno v:
Frontiers in Computational Neuroscience, Vol 12 (2018)
Neuronal action potentials or spikes provide a long-range, noise-resistant means of communication between neurons. As point processes single spikes contain little information in themselves, i.e., outside the context of spikes from other neurons. More
Externí odkaz:
https://doaj.org/article/ba549e047b7544e28f692af677f31272
Publikováno v:
Frontiers in Computational Neuroscience, Vol 11 (2017)
Understanding the relation between (sensory) stimuli and the activity of neurons (i.e., “the neural code”) lies at heart of understanding the computational properties of the brain. However, quantifying the information between a stimulus and a spi
Externí odkaz:
https://doaj.org/article/f155a66f3008483d97e4e18b377f3027
Autor:
Anirudh R. Acharya, Lars Emil Larsen, Jean Delbeke, Wytse J. Wadman, Kristl Vonck, Alfred Meurs, Paul Boon, Robrecht Raedt
Publikováno v:
CNS NEUROSCIENCE & THERAPEUTICS
AimsThe blue light-sensitive chloride-conducting opsin, stGtACR2, provides potent optogenetic silencing of neurons. The present study investigated whether activation of stGtACR2 in granule cells of the dentate gyrus (DG) inhibits epileptic afterdisch
Autor:
Robrecht Raedt, Sofie Carrette, Evelien Carrette, Paul Boon, Jean Delbeke, Wytse J. Wadman, Ann Mertens, Emma Lescrauwaet, Kristl Vonck, Debby Klooster
Publikováno v:
Neuromodulation, 25(3), 395-406. Wiley-Blackwell
Objectives: As a potential treatment for epilepsy, transcutaneous auricular vagus nerve stimulation (taVNS) has yielded inconsistent results. Combining transcranial magnetic stimulation with electromyography (TMS-EMG) and electroencephalography (TMS-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9caa9582962afe68d589169817f60d20
https://research.tue.nl/nl/publications/399538bb-f2cf-41bf-b8cd-8130f12d9955
https://research.tue.nl/nl/publications/399538bb-f2cf-41bf-b8cd-8130f12d9955
Autor:
Wytse J. Wadman, Robrecht Raedt, Paul Boon, Lars Emil Larsen, Mathieu Sprengers, Kristl Vonck, Jean Delbeke
Publikováno v:
Epilepsia, 61(5), 903-913. Wiley-Blackwell
OBJECTIVE: Deep brain stimulation (DBS) is an increasingly applied treatment for various neuropsychiatric disorders including drug-resistant epilepsy, and it may be optimized by rationalizing the stimulation protocol based on increased knowledge of i
Autor:
Lianne A. Hulshof, Nelda Antonovaite, Elly M. Hol, Davide Iannuzzi, Christiaan F. M. Huffels, Wytse J. Wadman
Publikováno v:
Journal of the Mechanical Behavior of Biomedical Materials, 122:104697. Elsevier BV
Antonovaite, N, Hulshof, L A, Huffels, C F M, Hol, E M, Wadman, W J & Iannuzzi, D 2021, ' Mechanical alterations of the hippocampus in the APP/PS1 Alzheimer's disease mouse model ', Journal of the Mechanical Behavior of Biomedical Materials, vol. 122, 104697 . https://doi.org/10.1016/j.jmbbm.2021.104697
Antonovaite, N, Hulshof, L A, Huffels, C F M, Hol, E M, Wadman, W J & Iannuzzi, D 2021, ' Mechanical alterations of the hippocampus in the APP/PS1 Alzheimer's disease mouse model ', Journal of the Mechanical Behavior of Biomedical Materials, vol. 122, 104697 . https://doi.org/10.1016/j.jmbbm.2021.104697
There is increasing evidence of altered tissue mechanics in neurodegeneration. However, due to difficulties in mechanical testing procedures and the complexity of the brain, there is still little consensus on the role of mechanics in the onset and pr