Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Wytse Hogewerf"'
Autor:
Mandy Koopman, Lale Güngördü, Leen Janssen, Renée I. Seinstra, Janet E. Richmond, Nathan Okerlund, René Wardenaar, Priota Islam, Wytse Hogewerf, Andre E.X. Brown, Erik M. Jorgensen, Ellen A.A. Nollen
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114204- (2024)
Summary: Amyotrophic lateral sclerosis can be caused by abnormal accumulation of TAR DNA-binding protein 43 (TDP-43) in the cytoplasm of neurons. Here, we use a C. elegans model for TDP-43-induced toxicity to identify the biological mechanisms that l
Externí odkaz:
https://doaj.org/article/59ffe124ab8347a4847a5c6cfc5bd77d
Autor:
Esther Stroo, Leen Janssen, Olga Sin, Wytse Hogewerf, Mirjam Koster, Liesbeth Harkema, Sameh A Youssef, Natalie Beschorner, Anouk HG Wolters, Bjorn Bakker, Lore Becker, Lilian Garrett, Susan Marschall, Sabine M Hoelter, Wolfgang Wurst, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabe de Angelis, Amantha Thathiah, Floris Foijer, Bart van de Sluis, Jan van Deursen, Matthias Jucker, Alain de Bruin, Ellen AA Nollen
Publikováno v:
Life science alliance 6(7), e202201730 (2023). doi:10.26508/lsa.202201730
In age-related neurodegenerative diseases, like Alzheimer’s and Parkinson’s, disease-specific proteins become aggregation-prone and form amyloid-like deposits. Depletion of SERF proteins ameliorates this toxic process in worm and human cell model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba2dc28445569fccfa99cc8b093ea779
https://pub.dzne.de/record/257883
https://pub.dzne.de/record/257883
Autor:
Janine Kirstein, Esther Stroo, Samantha Louise Edwards, Wytse Hogewerf, Anita Pras, Mandy Koopman, Matthias De Vleeschouwer, Joost Schymkowitz, Ellen A. A. Nollen, Michele Vendruscolo, Renée I. Seinstra, Christian Gallrein, Francesco A. Aprile, Alejandro Mata-Cabana, Rodrigo Gallardo, Bert Houben, Salvatore Fabio Falsone, Minke de Vries, Frederic Rousseau, Leen Janssen
Publikováno v:
The EMBO Journal
The EMBO Journal, 40(21):e107568. Wiley
The EMBO Journal, 40(21):e107568. Wiley
Funder: Ubbo Emmius fonds
Funder: Boehringer Ingelheim Fonds (BIF); Id: http://dx.doi.org/10.13039/501100001645
Funder: Cornelis de Cock
Funder: FP7 People Marie‐Curie Actions (PEOPLE)
Funder: BCN Brain RUG
Funder: KU Leuve
Funder: Boehringer Ingelheim Fonds (BIF); Id: http://dx.doi.org/10.13039/501100001645
Funder: Cornelis de Cock
Funder: FP7 People Marie‐Curie Actions (PEOPLE)
Funder: BCN Brain RUG
Funder: KU Leuve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ecf889dfd2240e37ce084f9da4161c9
http://hdl.handle.net/10044/1/92204
http://hdl.handle.net/10044/1/92204
Autor:
Renée I. Seinstra, S. Fabio Falsone, Joost Schymkowitz, Samantha Louise Edwards, Esther Stroo, Mandy Koopman, Wytse Hogewerf, Francesco A. Aprile, Anita Pras, Rodrigo Gallardo, Matthias De Vleeschouwer, Michele Vendruscolo, Leen Janssen, Frederic Rousseau, Alejandro Mata-Cabana, Ellen A. A. Nollen, Minke de Vries, Bert Houben
While aggregation-prone proteins are known to accelerate ageing and cause age-related diseases, the cellular mechanisms that drive their cytotoxicity remain unresolved. The orthologous proteins MOAG-4, SERF1A and SERF2 have recently been identified a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85252cf3e52367877b4d9ec1d86e8db1
https://doi.org/10.1101/2020.12.09.417709
https://doi.org/10.1101/2020.12.09.417709
Autor:
Francesco A. Aprile, Michele Vendruscolo, Wytse Hogewerf, Anne Steinhof, Renée I. Seinstra, Esther Stroo, Tristan V. de Jong, Mohamad Amr Zaini, Victor Guryev, Olga Sin, Roméo Willinge Prins, Erich E. Wanker, Valerie Reinke, Ellen A. A. Nollen, Hai Hui Wang, Michelle M. Kudron, Alejandro Mata-Cabana, Celine N. Martineau, Cornelis F. Calkhoven
Publikováno v:
Molecular Cell
Molecular Cell, 65(6), 1096-1108. CELL PRESS
Molecular Cell, 65(6), 1096-1108. CELL PRESS
Summary Protein aggregation is associated with age-related neurodegenerative disorders, such as Alzheimer’s and polyglutamine diseases. As a causal relationship between protein aggregation and neurodegeneration remains elusive, understanding the ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e49ac8b7e738cdd40f9553c84750cf6
https://research.rug.nl/en/publications/b07f1a85-8118-40ee-a7d2-94d002751a65
https://research.rug.nl/en/publications/b07f1a85-8118-40ee-a7d2-94d002751a65
Autor:
Marc-Jan van Goethem, Robert P. Coppes, Peter van Luijk, Johannes A. Langendijk, Reinier Bron, Sytze Brandenburg, Wytse Hogewerf, Maarten Niemantsverdriet
Publikováno v:
International Journal of Radiation Oncology Biology Physics, 83(4), 1291-1297. ELSEVIER SCIENCE INC
Purpose: Radiotherapy using high linear energy transfer (LET) radiation is aimed at efficiently killing tumor cells while minimizing dose (biological effective) to normal tissues to prevent toxicity. It is well established that high LET radiation res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc729366cc64971bdbcfaa49798a6545
https://research.rug.nl/en/publications/2d083218-147a-4d2e-a7b2-057359b8483c
https://research.rug.nl/en/publications/2d083218-147a-4d2e-a7b2-057359b8483c
Autor:
Robert P. Coppes, Wytse Hogewerf, H. Langendijk, M.J. van Goethem, Reinier Bron, Maarten Niemantsverdriet, P. van Luijk, Sijtze Brandenburg
Publikováno v:
STARTPAGE=S39;ENDPAGE=S39;TITLE=None
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::484be3e45f53ac79a71403038dd5b2ae
https://research.rug.nl/en/publications/a3f2e399-0006-4801-aa21-1fcd233b59cf
https://research.rug.nl/en/publications/a3f2e399-0006-4801-aa21-1fcd233b59cf