Helicase-assisted continuous editing for programmable mutagenesis of endogenous genomes.

Autor: Chen XD; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.; Systems, Synthetic, and Quantitative Biology PhD Program, Harvard University, Cambridge, MA 02138, USA., Chen Z; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Cell Biology and Pathology, Harvard Medical School, Boston, MA 02115, USA., Wythes G; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Zhang Y; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Orr BC; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA., Sun G; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Cell Biology and Pathology, Harvard Medical School, Boston, MA 02115, USA., Chao YK; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA., Navarro Torres A; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Thao K; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Vallurupalli M; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Sun J; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Borji M; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Tkacik E; Systems, Synthetic, and Quantitative Biology PhD Program, Harvard University, Cambridge, MA 02138, USA., Chen H; Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Bernstein BE; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Cell Biology and Pathology, Harvard Medical School, Boston, MA 02115, USA.; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Chen F; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2024 Oct 11; Vol. 386 (6718), pp. eadn5876. Date of Electronic Publication: 2024 Oct 11.