Zobrazeno 1 - 10
of 184
pro vyhledávání: '"Wynne, Aherne"'
Autor:
Michelle D. Garrett, Ian Collins, Paul Workman, Suzanne A. Eccles, Florence I. Raynaud, Wynne Aherne, Neil T. Thompson, John J. Caldwell, Gowri Vijayaraghavan, Lisa Pickard, Alan Henley, Simon P. Heaton, Ruth Ruddle, Paul D. Eve, Alexis de Haven Brandon, Melanie Valenti, Lisa-Jane K. Hunter, Mike I. Walton, Timothy A. Yap
Supplementary Figures 1-4 from Preclinical Pharmacology, Antitumor Activity, and Development of Pharmacodynamic Markers for the Novel, Potent AKT Inhibitor CCT128930
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::152e6b9e2a7c0fc3cf17558fd7b2c7b2
https://doi.org/10.1158/1535-7163.22496215.v1
https://doi.org/10.1158/1535-7163.22496215.v1
Autor:
Michelle D. Garrett, Ian Collins, Paul Workman, Suzanne A. Eccles, Florence I. Raynaud, Wynne Aherne, Neil T. Thompson, John J. Caldwell, Gowri Vijayaraghavan, Lisa Pickard, Alan Henley, Simon P. Heaton, Ruth Ruddle, Paul D. Eve, Alexis de Haven Brandon, Melanie Valenti, Lisa-Jane K. Hunter, Mike I. Walton, Timothy A. Yap
Supplementary Figure Legends and Supplementary Table 1 from Preclinical Pharmacology, Antitumor Activity, and Development of Pharmacodynamic Markers for the Novel, Potent AKT Inhibitor CCT128930
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67936b34bb07aa265992163ae6426afc
https://doi.org/10.1158/1535-7163.22496218.v1
https://doi.org/10.1158/1535-7163.22496218.v1
Autor:
Michelle D. Garrett, Ian Collins, Paul Workman, Suzanne A. Eccles, Florence I. Raynaud, Wynne Aherne, Neil T. Thompson, John J. Caldwell, Gowri Vijayaraghavan, Lisa Pickard, Alan Henley, Simon P. Heaton, Ruth Ruddle, Paul D. Eve, Alexis de Haven Brandon, Melanie Valenti, Lisa-Jane K. Hunter, Mike I. Walton, Timothy A. Yap
AKT is frequently deregulated in cancer, making it an attractive anticancer drug target. CCT128930 is a novel ATP-competitive AKT inhibitor discovered using fragment- and structure-based approaches. It is a potent, advanced lead pyrrolopyrimidine com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ccf70ce5d4c987a11727e4158ff1adf
https://doi.org/10.1158/1535-7163.c.6535195.v1
https://doi.org/10.1158/1535-7163.c.6535195.v1
Autor:
Michelle D. Garrett, Ian Collins, Suzanne A. Eccles, Florence I. Raynaud, Louis Chesler, John C. Reader, G. Wynne Aherne, Simon P. Robinson, Yann Jamin, Thomas P. Matthews, Michael Lainchbury, Kathy J. Boxall, Elizabeth L. Smith, Albert Hallsworth, Gary Box, Alexis K. De Haven Brandon, Melanie R. Valenti, Angela Hayes, Paul D. Eve, Mike I. Walton
PDF file, 79K, Supplementary Table 3 - Mouse body weights for data in Figure 4A Body Weights expressed as a percentage of the weight on day 0 for mice bearing HT29 xenografts and treated with gemcitabine (100mg/kg iv), CCT244747 (75mg/kg po) or the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::401ea57b719c1a1d93ab5881aa5484ab
https://doi.org/10.1158/1078-0432.22445615
https://doi.org/10.1158/1078-0432.22445615
Autor:
Michelle D. Garrett, Ian Collins, Suzanne A. Eccles, Florence I. Raynaud, Louis Chesler, John C. Reader, G. Wynne Aherne, Simon P. Robinson, Yann Jamin, Thomas P. Matthews, Michael Lainchbury, Kathy J. Boxall, Elizabeth L. Smith, Albert Hallsworth, Gary Box, Alexis K. De Haven Brandon, Melanie R. Valenti, Angela Hayes, Paul D. Eve, Mike I. Walton
PDF file, 92K, Supplementary Figure 2. A constrained, scaffold docking model of CCT244747 in the ATP pocket of human CHK1 realized using the SAR-020106 X-ray crystal structure (PDB 2ym8).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9db6fcbdeb80531e3ddd7d42e0cafbdd
https://doi.org/10.1158/1078-0432.22445639
https://doi.org/10.1158/1078-0432.22445639
Autor:
Michelle D. Garrett, Ian Collins, John C. Reader, David H. Williams, Florence I. Raynaud, Suzanne A. Eccles, G. Wynne Aherne, Kathy J. Boxall, Gary Box, Alexis De Haven Brandon, Melanie Valenti, Angela Hayes, Paul D. Eve, Michael I. Walton
PDF file, 63KB, Kinase inhibitory profile of SAR-020106 at 10 μMa.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32afb33095afaa0235fcca7f9841e0bf
https://doi.org/10.1158/1535-7163.22485369
https://doi.org/10.1158/1535-7163.22485369
Autor:
Michelle D. Garrett, Ian Collins, Suzanne A. Eccles, Florence I. Raynaud, Louis Chesler, John C. Reader, G. Wynne Aherne, Simon P. Robinson, Yann Jamin, Thomas P. Matthews, Michael Lainchbury, Kathy J. Boxall, Elizabeth L. Smith, Albert Hallsworth, Gary Box, Alexis K. De Haven Brandon, Melanie R. Valenti, Angela Hayes, Paul D. Eve, Mike I. Walton
PDF file, 118K, Supplementary Table 2 Summary of Effects of Irinotecan, Gemcitabine and CCT244747 alone or in combination on human tumor xenografts growth delay.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d1bd0e4da26aa07abae832d484513eb
https://doi.org/10.1158/1078-0432.22445618
https://doi.org/10.1158/1078-0432.22445618
Autor:
Michelle D. Garrett, Ian Collins, Suzanne A. Eccles, Florence I. Raynaud, Louis Chesler, John C. Reader, G. Wynne Aherne, Simon P. Robinson, Yann Jamin, Thomas P. Matthews, Michael Lainchbury, Kathy J. Boxall, Elizabeth L. Smith, Albert Hallsworth, Gary Box, Alexis K. De Haven Brandon, Melanie R. Valenti, Angela Hayes, Paul D. Eve, Mike I. Walton
PDF file, 810K, Supplementary Figure 3 Characterisation of the effects of minimally toxic concentrations of CCT244747 alone or in combination with genotoxic agents (+) in HT29 and SW620 colon cancer cell lines. A, HT29 cells were treated with SN38 (1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::343131448e94d2702194f9a5362972e1
https://doi.org/10.1158/1078-0432.22445636
https://doi.org/10.1158/1078-0432.22445636
Autor:
Paul Workman, Martin Drysdale, Sue Eccles, Florence Raynaud, Edward McDonald, Keith Jones, Laurence Pearl, Wynne Aherne, Roderick E. Hubbard, Nicolas Foloppe, Allan Surgenor, Lisa Wright, Julie E. Cansfield, Xavier Barril, Paul A. Brough, Brian Dymock, Anthea Hardcastle, Angela Hayes, Karen James, Andrew Kalusa, Kwai-Ming J. Cheung, Thomas P. Matthews, Gary Box, Joanna L. Holmes, Marissa V. Powers, Kathy Boxall, Chrisostomos Prodromou, Swee Y. Sharp
Adobe PDF - MCT-07-0149--Suppl_Data.pdf from Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d4d7fb2338ed0110488ee5feca6169d
https://doi.org/10.1158/1535-7163.22485900
https://doi.org/10.1158/1535-7163.22485900
Autor:
Michelle D. Garrett, Ian Collins, Suzanne A. Eccles, Florence I. Raynaud, Louis Chesler, John C. Reader, G. Wynne Aherne, Simon P. Robinson, Yann Jamin, Thomas P. Matthews, Michael Lainchbury, Kathy J. Boxall, Elizabeth L. Smith, Albert Hallsworth, Gary Box, Alexis K. De Haven Brandon, Melanie R. Valenti, Angela Hayes, Paul D. Eve, Mike I. Walton
PDF file, 76K, Supplementary Table 1 Kinome selectivity profile of CCT244747 CCT244747 was tested at 1 μM (140 enzymes) and 10 μM (121 enzymes) for inhibition of human kinases in a radiometric protein phosphorylation assay (MRC Protein Phosphorylat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbea4bf2cbee88a83459a4ad37108cee
https://doi.org/10.1158/1078-0432.22445621.v1
https://doi.org/10.1158/1078-0432.22445621.v1