Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Wylie Hosmer"'
Autor:
Alexander Vartanov, Aditi Kalotra, Jasmine Varughese, Shovendra Gautam, Sean Kandel, Wylie Hosmer
Publikováno v:
Respiratory Medicine Case Reports, Vol 33, Iss , Pp 101390- (2021)
The role for PD-1/PD-L1 and CTLA-4 targeted immunotherapy is well outlined in the treatment of metastatic NSCLC. Increased survival benefit supports the use of these medications and the development of next-generation agents with improved efficacy and
Externí odkaz:
https://doaj.org/article/d02a61f88d384e54ad8b0bf6f6275c8f
Autor:
Dennis J. Slamon, Steven M. Dubinett, Manway Liu, Cornelia Quadt, Michael Rugaard Jensen, Emin Avsar, Susan Ide, Wylie Hosmer, Amrita J. Desai, Naeimeh Kamranpour, Sharon Pitts, Judy Dering, Habib Hamidi, Richard S. Finn, Edward B. Garon
PDF - 69K, Supplemental Figure Legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5cc944f3707f5ad259f84b88e0f28a
https://doi.org/10.1158/1535-7163.22500510
https://doi.org/10.1158/1535-7163.22500510
Autor:
Dennis J. Slamon, Steven M. Dubinett, Manway Liu, Cornelia Quadt, Michael Rugaard Jensen, Emin Avsar, Susan Ide, Wylie Hosmer, Amrita J. Desai, Naeimeh Kamranpour, Sharon Pitts, Judy Dering, Habib Hamidi, Richard S. Finn, Edward B. Garon
Heat shock protein 90 (HSP90) is involved in protein folding and functions as a chaperone for numerous client proteins, many of which are important in non–small cell lung cancer (NSCLC) pathogenesis. We sought to define preclinical effects of the H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::340bde653ea76e976bddef604a102046
https://doi.org/10.1158/1535-7163.c.6536484.v1
https://doi.org/10.1158/1535-7163.c.6536484.v1
Autor:
Dennis J. Slamon, Steven M. Dubinett, Manway Liu, Cornelia Quadt, Michael Rugaard Jensen, Emin Avsar, Susan Ide, Wylie Hosmer, Amrita J. Desai, Naeimeh Kamranpour, Sharon Pitts, Judy Dering, Habib Hamidi, Richard S. Finn, Edward B. Garon
PDF - 769K, Heat maps from microarray analyses of gene expression changes seen in at least 13 of 16 experiments after exposure to NVP-AUY922
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2337f1f4ea5f861ba5a922f87b2c414c
https://doi.org/10.1158/1535-7163.22500516.v1
https://doi.org/10.1158/1535-7163.22500516.v1
Autor:
Dennis J. Slamon, Steven M. Dubinett, Manway Liu, Cornelia Quadt, Michael Rugaard Jensen, Emin Avsar, Susan Ide, Wylie Hosmer, Amrita J. Desai, Naeimeh Kamranpour, Sharon Pitts, Judy Dering, Habib Hamidi, Richard S. Finn, Edward B. Garon
PDF - 47B, A tabular demonstration of the efficacy and tolerability of NVP-AUY922 in 32 mice carrying subcutaneous A549 or H1975 xenograft tumors randomized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b3156a31aed59157028623a7831bffe
https://doi.org/10.1158/1535-7163.22500507
https://doi.org/10.1158/1535-7163.22500507
Autor:
Dennis J. Slamon, Paul Smith, Tim French, David Elashoff, Amrita Desai, Sharon Pitts, Naeimeh Kamranpour, Shahriar Adhami, Charles Ginther, Judy Dering, Wylie Hosmer, Richard S. Finn, Edward B. Garon
Selumetinib (AZD6244; ARRY-142886) is a tight-binding, uncompetitive inhibitor of mitogen-activated protein kinase kinases (MEK) 1 and 2 currently in clinical development. We evaluated the effects of selumetinib in 31 human breast cancer cell lines a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26ff809ecb2d29e3debc68b98e6353ac
https://doi.org/10.1158/1535-7163.c.6531540
https://doi.org/10.1158/1535-7163.c.6531540
Autor:
Dennis J. Slamon, Paul Smith, Tim French, David Elashoff, Amrita Desai, Sharon Pitts, Naeimeh Kamranpour, Shahriar Adhami, Charles Ginther, Judy Dering, Wylie Hosmer, Richard S. Finn, Edward B. Garon
Supplementary Data from Identification of Common Predictive Markers of In vitro Response to the Mek Inhibitor Selumetinib (AZD6244; ARRY-142886) in Human Breast Cancer and Non–Small Cell Lung Cancer Cell Lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62612360485d09c95ee1bd7cbc8e8ecc
https://doi.org/10.1158/1535-7163.22484697
https://doi.org/10.1158/1535-7163.22484697
Autor:
Diana C. Márquez-Garbán, Sharon Pitts, Amrita J. Desai, Richard J. Pietras, Wylie Hosmer, Richard S. Finn, Dennis J. Slamon, Erika von Euw, Judy Dering, Steven M. Dubinett, Naeimeh Kamranpour, Edward B. Garon
Publikováno v:
Journal of Thoracic Oncology. 8(3):270-278
Introduction Estrogen receptor (ER) signaling and its interaction with epidermal growth factor receptor (EGFR) is a potential therapeutic target in non–small-cell lung cancer (NSCLC). To explore cross-communication between ER and EGFR, we have corr
Publikováno v:
Supportive Care in Cancer
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, vol 19, iss 3
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, vol 19, iss 3
Purpose Current guidelines recommend prophylactic use of granulocyte-colony stimulating factors (G-CSF) when febrile neutropenia (FN) risk is greater than 20%. Advanced age is a risk factor for FN; however, little is known about the impact of other f
Autor:
Evangelos D. Michelakis, Heather R. Christofk, Carolyn D. Britten, Alexander C. Black, Sharon Pitts, Naeimeh Kamranpour, Wylie Hosmer, Agnes Bahng, Matthew J. Crabtree, Cecil Patel, Steven M. Dubinett, Dennis J. Slamon, Edward B. Garon, Candice Sun Hong, Fairooz F. Kabbinavar, Erika von Euw
Publikováno v:
Journal of cancer research and clinical oncology, vol 140, iss 3
Garon, EB; Christofk, HR; Hosmer, W; Britten, CD; Bahng, A; Crabtree, MJ; et al.(2014). Dichloroacetate should be considered with platinum-based chemotherapy in hypoxic tumors rather than as a single agent in advanced non-small cell lung cancer. Journal of Cancer Research and Clinical Oncology, 140(3), 443-452. doi: 10.1007/s00432-014-1583-9. UCLA: Retrieved from: http://www.escholarship.org/uc/item/1gr4w823
Garon, EB; Christofk, HR; Hosmer, W; Britten, CD; Bahng, A; Crabtree, MJ; et al.(2014). Dichloroacetate should be considered with platinum-based chemotherapy in hypoxic tumors rather than as a single agent in advanced non-small cell lung cancer. Journal of Cancer Research and Clinical Oncology, 140(3), 443-452. doi: 10.1007/s00432-014-1583-9. UCLA: Retrieved from: http://www.escholarship.org/uc/item/1gr4w823
Objectives: Dichloroacetate (DCA) is a highly bioavailable small molecule that inhibits pyruvate dehydrogenase kinase, promoting glucose oxidation and reversing the glycolytic phenotype in preclinical cancer studies. We designed this open-label phase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1ac291341524017e5ffbe7a833b2645
https://escholarship.org/uc/item/1gr4w823
https://escholarship.org/uc/item/1gr4w823