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Sembragiline: A Novel, Selective Monoamine Oxidase Type B Inhibitor for the Treatment of Alzheimer's Disease

Autor: Bart A. Ellenbroek, Axel Pähler, Bernd Bohrmann, Hansruedi Loetscher, Edilio Borroni, Wyler Rene, Julie K. Andersen, Juerg Messer, Anand Rane, Andrea M. Cesura, Stephane Nave, Fiona Grueninger, Subramanian Rajagopalan, Shankar J. Chinta, Eric Prinssen, Almas Siddiqui

Publikováno v: The Journal of pharmacology and experimental therapeutics. 362(3)

Monoamine oxidase B (MAO-B) has been implicated in the pathogenesis of Alzheimer's disease (AD) and other neurodegenerative disorders. Increased MAO-B expression in astroglia has been observed adjacent to amyloid plaques in AD patient brains. This ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aacf63885b6c44711a1262e8f93416f
https://pubmed.ncbi.nlm.nih.gov/28642233

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Akademický článek

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Replication and assembly

Autor: Edward A. Wintner, M. Morgan Conn, Julius Rebek, J. De Mendoza, C. Valdez, Neil R. Branda, Ivan Huc, Yoko Kato, Amalia Galán, Wyler Rene, M. Tymoschenko, René Beerli, Cecilia Andreu

Publikováno v: Pure and Applied Chemistry. 65:2313-2318

Molecules bearing surfaces capable of recognition phenomena can be covalently attached to each other to give self-complementary structures. Such molecules can reveal autocatalytic effects as replicators, and they are able to assemble in a variety of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::90ac899066b72ba8a0ca476cd36fd67f
https://doi.org/10.1351/pac199365112313

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2-Styryl-pyridines and 2-(3,4-Dihydro-naphthalen-2-yl)pyridines as Potent NR1/2B Subtype Selective NMDA Receptor Antagonists

Autor: Marie-Paule Heitz, Emmanuel Pinard, Gerhard Trube, Anne Bourson, Ramanjit Gill, Alexander Alanine, Wyler Rene, Vincent Mutel, Bernd Buettelmann

Publikováno v: CHIMIA, Vol 58, Iss 9 (2004)

A series of 2-styryl-pyridines and 2-(3,4-dihydro-naphthalen-2-yl)-pyridines was prepared and evaluated as NR1/2B subtype selective NMDA receptor antagonists. The SAR developed in this series resulted in the discovery of high affinity antagonists tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3561c20feed03174bb7ba14b6cec2167
https://chimia.ch/chimia/article/view/3879

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Pharmacological characterization of Ro 63-1908 (1-[2-(4-hydroxy-phenoxy)-ethyl]-4-(4-methyl-benzyl)-piperidin-4-ol), a novel subtype-selective N-methyl-D-aspartate antagonist

Autor: R. Wybrecht, Bernd Büttelmann, B. Levet-Trafit, Wyler Rene, John A. Kemp, M. P. Heitz, Pari Malherbe, M. Schmitt, M.-T. Miss, A. Alanine, H.-P. Lorez, Ramanjit Gill, Gerhard Trube, Vincent Mutel, S. Roever, Günther Fischer, E. Pinard, Anne Bourson, James N.C. Kew

Publikováno v: The Journal of pharmacology and experimental therapeutics. 302(3)

Ro 63-1908, 1-[2-(4-hydroxy-phenoxy)-ethyl]-4-(4-methyl-benzyl)-piperidin-4-ol, is a novel subtype-selective N-methyl-D-aspartate (NMDA) antagonist that has been characterized in vitro and in vivo. Ro 63-1908 inhibited [(3)H]dizocilpine ((3)H-MK-801)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1efe95f096110c9ea49dcd4f10661c11
https://pubmed.ncbi.nlm.nih.gov/12183650

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