Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Wyle Solomon"'
Autor:
Lee Shangold, William Hanes, Wyle Solomon, Adam Williamson, Florian Missey, Malin Silvera Ejneby, Jan Trajilinek
Publikováno v:
SLEEP. 46:A219-A220
Introduction Hypoglossal nerve stimulation has proven effective as an alternative to Positive Airway Pressure (PAP) machines in treating obstructive sleep apnea (OSA). The only currently FDA-approved hypoglossal nerve stimulator requires surgical imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9aebee91bb4135e7ba8845afc1ab66bc
https://doi.org/10.1093/sleep/zsad077.0494
https://doi.org/10.1093/sleep/zsad077.0494
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:1261-1264
The synthesis of bicyclo[7.4.1]enediynes 2a and 2b are described. The bicyclo[7.4.1]enediyne 2b was found to be a poor DNA cleaver but did cause damage to several protein isolates.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c35f33028e7052d5c643957d5edf41f8
https://doi.org/10.1016/0960-894x(96)00212-0
https://doi.org/10.1016/0960-894x(96)00212-0
Autor:
Kahnie Pham, Mark D. Wittman, Nada Zein, Wyle Solomon, Harold Mastalerz, Dolatrai M. Vyas, William C. Rose, Leung Kinwa, John F. Kadow
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:2925-2928
The thiol activation and aromatization of bicyclo[7.1.0]enediynes was found to be dependent of the nature of the propargyl substituent. These effects are correlated to antitumor activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0c8326c56de13bc1ce1b068b0e97d68
https://doi.org/10.1016/s0960-894x(01)80841-6
https://doi.org/10.1016/s0960-894x(01)80841-6
Autor:
John F. Kadow, Nada Zein, William C. Rose, Stephen W. Mamber, Wyle Solomon, Daniel Richard Marshall, Gregory Roth
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:711-714
A series of electronically and sterically altered enediyne cores, based on esperamicin, were prepared using a cobalt mediated cyclization strategy in an attempt to improve the antitumor activity of this class of compounds. The biological activity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::615a9f5cbb363c7caa53949a3adf17df
https://doi.org/10.1016/s0960-894x(01)80185-2
https://doi.org/10.1016/s0960-894x(01)80185-2
Autor:
Anna Maria Casazza, John F. Kadow, Wyle Solomon, Nada Zein, Terrence W. Doyle, Dolatrai M. Vyas, Min Min Tun, Bala Krishnan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:1351-1356
The simple enediyne core molecule 1 is shown to cause protein damage to several cellular protein isolates in vitro. The aromatization of 1 to generate a benzene diradical under simulated physiological conditions is also described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::975d090a3ff55fcfdf7a3e87bb8432d7
https://doi.org/10.1016/s0960-894x(00)80347-9
https://doi.org/10.1016/s0960-894x(00)80347-9
Publikováno v:
ChemInform. 27
The synthesis of bicyclo[7.4.1]enediynes 2a and 2b are described. The bicyclo[7.4.1]enediyne 2b was found to be a poor DNA cleaver but did cause damage to several protein isolates.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdf5a821a0d6010d6394605ea1cb7384
https://doi.org/10.1002/chin.199642092
https://doi.org/10.1002/chin.199642092
Publikováno v:
Biochemistry. 34(36)
Maduropeptin (MDP) is a recently isolated antitumor antibiotic, consisting of an enediyne-containing chromophore embedded in a highly acidic protein. This holoantibiotic damages duplex DNA in vitro, producing a mixture of single- and double-strand br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::963d01827bc845174bcbdc7fa6e4538f
https://pubmed.ncbi.nlm.nih.gov/7547890
https://pubmed.ncbi.nlm.nih.gov/7547890
Publikováno v:
Journal of the American Chemical Society. 115:12627-12628
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83dde88f76da4196a7d1c9ca4160e18f
https://doi.org/10.1021/ja00079a069
https://doi.org/10.1021/ja00079a069