Zobrazeno 1 - 10
of 245
pro vyhledávání: '"Wyeth W Wasserman"'
Autor:
Phillip Andrew Richmond, Alice Mary Kaye, Godfrain Jacques Kounkou, Tamar Vered Av-Shalom, Wyeth W Wasserman
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 3, p e1008815 (2021)
Across the life sciences, processing next generation sequencing data commonly relies upon a computationally expensive process where reads are mapped onto a reference sequence. Prior to such processing, however, there is a vast amount of information t
Externí odkaz:
https://doaj.org/article/80aea80618184eab822ac33dc4b8646d
Autor:
Alissandra de Moura Gomes, Terri L. Petkau, Andrea J. Korecki, Oriol Fornes, Adriana Galvan, Ge Lu, Austin M. Hill, Siu Ling Lam, Anqi Yao, Rachelle A. Farkas, Wyeth W. Wasserman, Yoland Smith, Elizabeth M. Simpson, Blair R. Leavitt
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract Compact cell type-specific promoters are important tools for basic and preclinical research and clinical delivery of gene therapy. In this work, we designed novel MiniPromoters to target D1 and D2 type dopaminoceptive medium spiny neurons in
Externí odkaz:
https://doaj.org/article/ccbb413e18624dfaadafe59f90e06ce7
Autor:
Puya Seid-Karbasi, Xin C Ye, Allen W Zhang, Nicole Gladish, Suzanne Y S Cheng, Katharina Rothe, Jessica A Pilsworth, Min A Kang, Natalie Doolittle, Xiaoyan Jiang, Peter C Stirling, Wyeth W Wasserman
Publikováno v:
PLoS Biology, Vol 15, Iss 3, p e2001192 (2017)
Student creation of educational materials has the capacity both to enhance learning and to decrease costs. Three successive honors-style classes of undergraduate students in a cancer genetics class worked with a new software system, CuboCube, to crea
Externí odkaz:
https://doaj.org/article/0f991d7c342c4fe09f41abcc77b6c2de
Autor:
Jack W Hickmott, Chih-yu Chen, David J Arenillas, Andrea J Korecki, Siu Ling Lam, Laurie L Molday, Russell J Bonaguro, Michelle Zhou, Alice Y Chou, Anthony Mathelier, Sanford L Boye, William W Hauswirth, Robert S Molday, Wyeth W Wasserman, Elizabeth M Simpson
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Current gene therapies predominantly use small, strong, and readily available ubiquitous promoters. However, as the field matures, the availability of small, cell-specific promoters would be greatly beneficial. Here we design seven small promoters fr
Externí odkaz:
https://doaj.org/article/ec3b5f27a8ba4237bd6536d98ddff289
Autor:
Casper Shyr, Maja Tarailo-Graovac, Michael Gottlieb, Jessica JY Lee, Clara van Karnebeek, Wyeth W Wasserman
Publikováno v:
BMC Medical Genomics, Vol 10, Iss 1, Pp 1-1 (2017)
Correction Unfortunately, the original article [1] contained an error. The additional files were included incorrectly. The correct additional files 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13 and 14 are published in this correction.
Externí odkaz:
https://doaj.org/article/d9d11c14311c49a78e3921b142ce339d
Autor:
Charles N de Leeuw, Frank M Dyka, Sanford L Boye, Stéphanie Laprise, Michelle Zhou, Alice Y Chou, Lisa Borretta, Simone C McInerny, Kathleen G Banks, Elodie Portales-Casamar, Magdalena I Swanson, Cletus A D'Souza, Shannon E Boye, Steven JM Jones, Robert A Holt, Daniel Goldowitz, William W Hauswirth, Wyeth W Wasserman, Elizabeth M Simpson
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 1, Iss C (2014)
Critical for human gene therapy is the availability of small promoters tools to drive gene expression in a highly specific and reproducible manner. We tackled this challenge by developing human DNA MiniPromoters (MiniPs) using computational biology a
Externí odkaz:
https://doaj.org/article/a4992868fae84ac68f19247787a4fd6f
Autor:
Anthony Mathelier, Wyeth W Wasserman
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 9, p e1003214 (2013)
Finding where transcription factors (TFs) bind to the DNA is of key importance to decipher gene regulation at a transcriptional level. Classically, computational prediction of TF binding sites (TFBSs) is based on basic position weight matrices (PWMs)
Externí odkaz:
https://doaj.org/article/338acd7d9de14561884e55355d54b698
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 12, p e1002256 (2011)
We performed a genome-wide scan for muscle-specific cis-regulatory modules (CRMs) using three computational prediction programs. Based on the predictions, 339 candidate CRMs were tested in cell culture with NIH3T3 fibroblasts and C2C12 myoblasts for
Externí odkaz:
https://doaj.org/article/6c9a710453c5402face97518a5837cbf
Autor:
Malin C Andersen, Pär G Engström, Stuart Lithwick, David Arenillas, Per Eriksson, Boris Lenhard, Wyeth W Wasserman, Jacob Odeberg
Publikováno v:
PLoS Computational Biology, Vol 4, Iss 1, p e5 (2008)
Identification of functional genetic variation associated with increased susceptibility to complex diseases can elucidate genes and underlying biochemical mechanisms linked to disease onset and progression. For genes linked to genetic diseases, most
Externí odkaz:
https://doaj.org/article/75312311854f482284de8f3108b9ae78
Autor:
Danielle Kemmer, Raf M Podowski, Dimas Yusuf, Jochen Brumm, Warren Cheung, Claes Wahlestedt, Boris Lenhard, Wyeth W Wasserman
Publikováno v:
PLoS ONE, Vol 3, Iss 1, p e1440 (2008)
We introduce the Gene Characterization Index, a bioinformatics method for scoring the extent to which a protein-encoding gene is functionally described. Inherently a reflection of human perception, the Gene Characterization Index is applied for asses
Externí odkaz:
https://doaj.org/article/ed971e84803345ddb9072328bc984619