Výsledky vyhledávání - "Wyeth Alexander"

Traumatic injury results in prolonged circulation of ultralarge von Willebrand factor and a reduction in ADAMTS13 activity

Autor: Jason L. Sperry, Margaret V. Ragni, Francis X. Guyette, Mitchell Dyer, Marian A. Rollins-Raval, Wyeth Alexander, A Tactic Publication, William E. Plautz, Brian S. Zuckerbraun, Jay S. Raval, Shannon Haldeman, Matthew D. Neal

Publikováno v: Transfusion. 60:1308-1318

Background Increases in plasma von Willebrand Factor (VWF) levels, accompanied by decreases in the metalloprotease ADAMTS13, have been demonstrated soon after traumatic injury while downstream effects remain unclear. Study design and methods A cohort

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2590b7ad106ed086a73f2d58bd84ad31
https://doi.org/10.1111/trf.15856

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Platelet-derived extracellular vesicles released after trauma promote hemostasis and contribute to DVT in mice

Autor: Will Plautz, Patricia Loughran, Yingjie Liu, Yoel Sadovsky, Matthew D. Neal, Wyeth Alexander, Brian S. Zuckerbraun, Tomasz Brzoska, Hui Li, Qiwei Chen, Prithu Sundd, Mitchell Dyer, Shannon Haldeman, Brian A. Boone, Jurgis Alvikas, Adnan Hassoune

Publikováno v: J Thromb Haemost

Background Traumatic injury can lead to dysregulation of the normal clotting system, resulting in hemorrhagic and thrombotic complications. Platelet activation is robust following traumatic injury and one process of platelet activation is to release

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c62f1f8f142f13dbbb3ae13044c2df4
https://europepmc.org/articles/PMC6773503/

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Measurement of microparticle tissue factor activity in clinical samples: A summary of two tissue factor-dependent FXa generation assays

Autor: Peter M. Voorhees, Yohei Hisada, Angela M. Taylor, Nigel S. Key, Wyeth Alexander, Coleen A. McNamara, Raj S. Kasthuri, Nigel Mackman, Fariborz Mobarrez, Ursula Rauch, Marco Witkowski, Håkan Wallén

Publikováno v: Thrombosis Research. 139:90-97

Thrombosis is a leading cause of morbidity and mortality. Detection of a prothrombotic state using biomarkers would be of great benefit to identify patients at risk of thrombosis that would benefit from thromboprophylaxis. Tissue factor (TF) is a hig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d4a932bfa6b36afc15870083ddc1d82
https://doi.org/10.1016/j.thromres.2016.01.011

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Prolonged Circulation of Ultra-Large Von Willebrand Factor and a Reduction in ADAMTS13 Activity Promotes Microvascular Disease Following Traumatic Injury

Autor: Marian A. Rollins-Raval, Brian S. Zuckerbraun, Jay S. Raval, Matthew D. Neal, Mitchell Dyer, Jason L. Sperry, Shannon Haldeman, William E. Plautz, Francis X. Guyette, Wyeth Alexander, Margaret V. Ragni

Publikováno v: Blood. 134:444-444

Introduction: Increases in plasma von Willebrand Factor (vWF) levels, accompanied by decreases in its respective metalloprotease, ADAMTS13, have been demonstrated in diseases of microvascular injury. We hypothesized that following severe trauma, a bu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d3fa81d3abec979563fb8bc883e2c417
https://doi.org/10.1182/blood-2019-124531

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Detection of tissue factor-positive extracellular vesicles by laser scanning confocal microscopy

Autor: Yohei Hisada, Nigel Mackman, Wyeth Alexander, Alyson C. Auriemma, Cihan Ay

Publikováno v: Thrombosis research. 150

Introduction Increased levels of tissue factor-positive extracellular vesicles (TF + EVs) have been detected in the plasma of patients with various diseases, including cancer and endotoxemia. Levels of TF + EVs in plasma samples can be measured by an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5edd0e213e218c1a7a00628e21e87bfb
https://pubmed.ncbi.nlm.nih.gov/28043041

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