Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer's disease ligands.

Autor: Greven JA; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri., Wydra JR; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri., Greer RA; Department of Biomedical Engineering, University of Alabama at Birmingham, Alabama., Zhi C; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri., Camitta C; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri., Song Y; Department of Biomedical Engineering, University of Alabama at Birmingham, Alabama., Alexander-Brett JM; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri.; Center for Regenerative Medicine, Washington University School of Medicine, St. Louis, Missouri 63110.; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri 63110., Brett TJ; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri.; Center for Regenerative Medicine, Washington University School of Medicine, St. Louis, Missouri 63110.; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri 63110.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri 63110.; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri 63110.

Publikováno v: Research square [Res Sq] 2024 Sep 12. Date of Electronic Publication: 2024 Sep 12.