DNAJB8 oligomerization is mediated by an aromatic-rich motif that is dispensable for substrate activity

Autor: Ryder, Bryan D., Ustyantseva, Elizaveta, Boyer, David R., Mendoza-Oliva, Ayde, Kuska, Mikołaj I., Wydorski, Paweł M., Macierzyńska, Paulina, Morgan, Nabil, Sawaya, Michael R., Diamond, Marc I., Kampinga, Harm H., Joachimiak, Lukasz A.

Publikováno v: In Structure 6 June 2024 32(6):662-678

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Ensemble-based design of tau to inhibit aggregation while preserving biological activity.

Autor: Bali S; Molecular Biophysics Graduate Program, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States.; Center for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, University of Texas., Singh R; Center for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, University of Texas., Wydorski PM; Molecular Biophysics Graduate Program, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States.; Center for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, University of Texas., Wosztyl A; Molecular Biophysics Graduate Program, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States., Perez VA; Center for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, University of Texas., Chen D; Center for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, University of Texas., Rizo J; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States Southwestern Medical Center, Dallas, TX 75390, United States.; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States.; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States., Joachimiak LA; Center for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, University of Texas.; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States.

Publikováno v: Research square [Res Sq] 2024 Jan 16. Date of Electronic Publication: 2024 Jan 16.

Dual domain recognition determines SARS-CoV-2 PLpro selectivity for human ISG15 and K48-linked di-ubiquitin.

Autor: Wydorski PM; Molecular Biophysics Graduate Program, University of Texas Southwestern Medical Center, Dallas, TX 75390 USA.; Center for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390 USA., Osipiuk J; Center for Structural Biology of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL, 60667 USA.; Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Lemont, IL, 60439 USA., Lanham BT; Department of Chemistry and Biochemistry, Center for Biomolecular Structure and Organization, University of Maryland, College Park, MD 20742 USA., Tesar C; Center for Structural Biology of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL, 60667 USA.; Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Lemont, IL, 60439 USA., Endres M; Center for Structural Biology of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL, 60667 USA.; Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Lemont, IL, 60439 USA., Engle E; Department of Chemistry and Biochemistry, Center for Biomolecular Structure and Organization, University of Maryland, College Park, MD 20742 USA., Jedrzejczak R; Center for Structural Biology of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL, 60667 USA.; Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Lemont, IL, 60439 USA., Mullapudi V; Center for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390 USA., Michalska K; Center for Structural Biology of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL, 60667 USA.; Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Lemont, IL, 60439 USA., Fidelis K; Protein Structure Prediction Center, Genome and Biomedical Sciences Facilities, University of California, Davis, CA, 95616 USA., Fushman D; Department of Chemistry and Biochemistry, Center for Biomolecular Structure and Organization, University of Maryland, College Park, MD 20742 USA., Joachimiak A; Center for Structural Biology of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL, 60667 USA.; Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Lemont, IL, 60439 USA.; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, 60367 USA., Joachimiak LA; Center for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390 USA.; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390 USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jan 19. Date of Electronic Publication: 2023 Jan 19.