Výsledky vyhledávání - "Wybe Martin Kast"

Peptide Vaccination with an Anchor-Replaced CTL Epitope Protects Against Human Papillomavirus Type 16-Induced Tumors Expressing the Wild-Type Epitope

Autor: Jacques Neefjes, Wybe Martin Kast, Anne Neisig, C. J. M. Melief, Michel P. M. Vierboom, J. W. Drijfhout, ter Schegget J, Mariet C.W. Feltkamp

Publikováno v: Scopus-Elsevier

Anchor residues in cytotoxic T-lymphocyte (CTL) epitope-bearing peptides are buried deep in the major histocompatibility complex (MHC) class I antigen-presenting groove and are essential for binding to MHC class I molecules. We investigated whether a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::721eaca9a5dd7c83cc687782f1dcfaa3
https://doi.org/10.1097/00002371-199811000-00001

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PEPTIDE SPECIFICITY OF ALLOREACTIVE CD4 POSITIVE T LYMPHOCYTES DIRECTED AGAINST A MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I DISPARITY1

Autor: M. L. H. De Bruijn, K. J. H. Van Veen, Miriam Ossevoort, C. J. M. Melief, Wybe Martin Kast

Publikováno v: Transplantation. 62:1485-1491

The mouse strains C57BL/6 (B6, H2 b ) and K bm1 mutant bm1 have a defined difference of three amino acids at position 152, 155, and 156 in the MHC class I K molecule. This causes a change in the side and the bottom of the antigen presenting groove of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3949420c6a88846417462b7d031ccb0f
https://doi.org/10.1097/00007890-199611270-00017

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An HLA class I peptide-binding assay based on competition for binding to class I molecules on intact human B cells

Autor: S.H. van der Burg, Andreas J.A. Bremers, Wybe Martin Kast, Elisabeth Ras, Jan W. Drijfhout, Willemien E. Benckhuijsen, C. J. M. Melief

Publikováno v: Human Immunology

A peptide-binding assay employing the HLA class I molecules on intact human B cells is described. The peptide antigens are stripped from the HLA class I molecules by mild acid treatment, after which the cells are incubated with a FL-labeled reference

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2f64ffb21f746dda0a9025e45c370e1c
https://doi.org/10.1016/0198-8859(95)00105-0

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Dendritic Cells as Carriers for a Cytotoxic T-Lymphocyte Epitope-Based Peptide Vaccine in Protection Against a Human Papillomavirus Type 16-Induced Tumor

Autor: Miriam Ossevoort, Wybe Martin Kast, Mariet C.W. Feltkamp, Cornelis J. M. Melief, K. J. H. Van Veen

Publikováno v: Journal of Immunotherapy. 18:86-94

Previously we have demonstrated that two doses of a cytotoxic T lymphocyte (CTL) epitope-based peptide vaccine of human papillomavirus type 16 (HPV 16) E7 aa 49-57 elicit protection against outgrowth of HPV 16-transformed tumor cells (C3 cells) in B6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e95f68e11552a347a22b4924d23304b
https://doi.org/10.1097/00002371-199508000-00002

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The Use of Epstein-Barr Virus-Transformed B Lymphocyte Cell Lines in a Peptide-Reconstitution Assay

Autor: C.J.H. van de Velde, Peter J. K. Kuppen, S.H. van der Burg, C. J. M. Melief, Andreas J.A. Bremers, Wybe Martin Kast

Publikováno v: Journal of Immunotherapy

In the development of cytotoxic T lymphocyte (CTL)-mediated immunotherapy, the identification of CTL epitopes is of crucial importance. Binding of a peptide to major histocompatibility complex (MHC) class I molecules is one of the prerequisites for i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7766eedaf29c63eac9bc158900f6724e
https://doi.org/10.1097/00002371-199508000-00001

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Antigen capture and major histocompatibility class II compartments of freshly isolated and cultured human blood dendritic cells

Autor: Monique J. Kleijmeer, Miriam Ossevoort, M. Van De Keur, Peter Kenemans, C. J. M. Melief, M. P. M. Vierboom, Wybe Martin Kast, Hans W. Nijman, Hans J. Geuze, Viola Oorschot

Publikováno v: The Journal of Experimental Medicine

Dendritic cells (DC) represent potent antigen-presenting cells for the induction of T cell-dependent immune responses. Previous work on antigen uptake and presentation by human DC is based largely on studies of blood DC that have been cultured for va

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https://doi.org/10.1084/jem.182.1.163

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Production of Interleukin-2 by EL4 Tumor Cells Induces Natural Killer Cell- and T-Cell-Mediated Immunity

Autor: E. I. H. van der Voort, L. A. Gravestein, Maarten Zijlstra, C. J. M. Melief, M. J. W. Visseren, M. Koot, Wybe Martin Kast, H. J. Schoenmakers

Publikováno v: Journal of Immunotherapy. 15:119-128

Systemic administration of recombinant interleukin (rIL)-2 to cancer patients has met with limited clinical success since, despite significant antitumor effects, its use is associated with severe toxicity. Local production of IL-2 by IL-2 gene transf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ca039e4254e6fe9ddfba65dcfc45779
https://doi.org/10.1097/00002371-199402000-00005

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In vitro induction of human cytotoxic T lymphocyte responses against peptides of mutant and wild-type p53

Autor: Frank Momburg, Wybe Martin Kast, J. W. Drijfhout, C.J.H. van de Velde, S.H. van der Burg, Anneke Brand, Peter Kenemans, Hans W. Nijman, J. G. A. Houbiers, Cornelis J. M. Melief

Publikováno v: European Journal of Immunology

The central role of the p53 tumor suppressor gene product in oncogenesis is gradually being clarified. Point mutations in the p53 tumor suppressor gene are common in most human cancers and are often associated with p53 protein overexpression. Overexp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cceabe3ba49503845c7442a64d1de435
https://doi.org/10.1002/eji.1830230905

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Characterization of Cytotoxic T Lymphocyte Epitopes of a Self-Protein, p53, and a Non-Self-Protein, Influenza Matrix

Autor: C. J. M. Melief, M. P. M. Vierboom, S.H. van der Burg, Peter Kenemans, J. G. A. Houbiers, Wybe Martin Kast, Hans W. Nijman

Publikováno v: Journal of Immunotherapy

We previously described a motif prediction of major histocompatibility complex allele-specific peptides and an in vitro assay for actual measurement of peptide binding to human leukocyte antigen HLA-A2.1 molecules. Using this method we have identifie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9e12e1742c81561397b630684136ddff
https://doi.org/10.1097/00002371-199308000-00007

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Pretransplantation Blood Transfusion Revisited

Autor: C. J. M. Melief, E. van Twuyver, J. M. Wilmink, I. J. M. ten Berge, R. J. D. Mooijaart, L. P. de Waal, A. R. van der Horst, Wybe Martin Kast

Publikováno v: New England journal of medicine, 325(17), 1210-1213. Massachussetts Medical Society

BACKGROUND: Blood transfusion before organ transplantation has a beneficial effect on allograft survival; the mechanism of this effect has remained a mystery. In murine models, the presence of common histocompatibility antigens in the blood donor and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d2af17ef4507cb649d25e9a1c85baf
https://doi.org/10.1056/nejm199110243251704

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