Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Wyatt W Yue"'
Autor:
Vincent Meynier, Steven W. Hardwick, Marjorie Catala, Johann J. Roske, Stephanie Oerum, Dimitri Y. Chirgadze, Pierre Barraud, Wyatt W. Yue, Ben F. Luisi, Carine Tisné
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The human mitochondrial genome is transcribed into two RNAs, containing mRNAs, rRNAs and tRNAs, all dedicated to produce essential proteins of the respiratory chain. The precise excision of tRNAs by the mitochondrial endoribonucleases (mt-RN
Externí odkaz:
https://doaj.org/article/9225da7769584f1e885d93f4594d97f7
Autor:
Linnea K. M. Blomgren, Melanie Huber, Sabrina R. Mackinnon, Céline Bürer, Arnaud Baslé, Wyatt W. Yue, D. Sean Froese, Thomas J. McCorvie
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract 5,10-methylenetetrahydrofolate reductase (MTHFR) commits folate-derived one-carbon units to generate the methyl-donor s-adenosyl-l-methionine (SAM). Eukaryotic MTHFR appends to the well-conserved catalytic domain (CD) a unique regulatory dom
Externí odkaz:
https://doaj.org/article/5004c4b595224327adf73c6b8e9c3779
Autor:
Thomas J. McCorvie, Douglas Adamoski, Raquel A. C. Machado, Jiazhi Tang, Henry J. Bailey, Douglas S. M. Ferreira, Claire Strain-Damerell, Arnaud Baslé, Andre L. B. Ambrosio, Sandra M. G. Dias, Wyatt W. Yue
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Cystathionine beta-synthase (CBS) is an essential metabolic enzyme across all domains of life for the production of glutathione, cysteine, and hydrogen sulfide. Appended to the conserved catalytic domain of human CBS is a regulatory domain t
Externí odkaz:
https://doaj.org/article/ab8b66b800d84595b9f0b297bda3a01f
Autor:
Glenda M. Beaman, Filipa M. Lopes, Aybike Hofmann, Wolfgang Roesch, Martin Promm, Emilia K. Bijlsma, Chirag Patel, Aykut Akinci, Berk Burgu, Jeroen Knijnenburg, Gladys Ho, Christina Aufschlaeger, Sylvia Dathe, Marie Antoinette Voelckel, Monika Cohen, Wyatt W. Yue, Helen M. Stuart, Edward A. Mckenzie, Mark Elvin, Neil A. Roberts, Adrian S. Woolf, William G. Newman
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Urofacial (also called Ochoa) syndrome (UFS) is an autosomal recessive congenital disorder of the urinary bladder featuring voiding dysfunction and a grimace upon smiling. Biallelic variants in HPSE2, coding for the secreted protein heparanase-2, are
Externí odkaz:
https://doaj.org/article/576f63e2c30d40a9aa5dc30cab4f03f1
Autor:
Sabrina R. Mackinnon, Gustavo A. Bezerra, Tobias Krojer, Tamas Szommer, Frank von Delft, Paul E. Brennan, Wyatt W. Yue
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
Primary hyperoxaluria type I (PH1) is caused by AGXT gene mutations that decrease the functional activity of alanine:glyoxylate aminotransferase. A build-up of the enzyme’s substrate, glyoxylate, results in excessive deposition of calcium oxalate c
Externí odkaz:
https://doaj.org/article/dfd6aa5544794ca1b1e7cb0be889d771
Autor:
Jesse A. Coker, Vittorio L. Katis, Michael Fairhead, Anja Schwenzer, Stine B. Clemmensen, Bent U. Frandsen, Willem A. de Jongh, Opher Gileadi, Nicola A. Burgess-Brown, Brian D. Marsden, Kim S. Midwood, Wyatt W. Yue
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Recombinant protein expression in eukaryotic insect cells is a powerful approach for producing challenging targets. However, due to incompatibility with standard baculoviral platforms and existing low-throughput methodology, the use of the Drosophila
Externí odkaz:
https://doaj.org/article/b1a66327cf994b558e7f1cba4b4aa7bc
Autor:
Gustavo A. Bezerra, William R. Foster, Henry J. Bailey, Kevin G. Hicks, Sven W. Sauer, Bianca Dimitrov, Thomas J. McCorvie, Jürgen G. Okun, Jared Rutter, Stefan Kölker, Wyatt W. Yue
Publikováno v:
IUCrJ, Vol 7, Iss 4, Pp 693-706 (2020)
DHTKD1 is a lesser-studied E1 enzyme among the family of 2-oxoacid dehydrogenases. In complex with E2 (dihydrolipoamide succinyltransferase, DLST) and E3 (dihydrolipoamide dehydrogenase, DLD) components, DHTKD1 is involved in lysine and tryptophan ca
Externí odkaz:
https://doaj.org/article/f5c7b911e55a49b5ba415171e6dd2ab1
Autor:
Henry J. Bailey, Gustavo A. Bezerra, Jason R. Marcero, Siladitya Padhi, William R. Foster, Elzbieta Rembeza, Arijit Roy, David F. Bishop, Robert J. Desnick, Gopalakrishnan Bulusu, Harry A. Dailey, Wyatt W. Yue
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Mutation of the C-terminal extension of 5′-aminolevulinate synthase 2 (ALAS2) is the molecular cause for X-linked protoporphyria, but the underlying mechanism is unclear. Based on crystal structures and MD simulations of ALAS2, the authors here sho
Externí odkaz:
https://doaj.org/article/b469b0462bc94b0e8a1d29a9113fb32b
Autor:
Nicholas G. Fox, Xiaodi Yu, Xidong Feng, Henry J. Bailey, Alain Martelli, Joseph F. Nabhan, Claire Strain-Damerell, Christine Bulawa, Wyatt W. Yue, Seungil Han
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
The iron-sulfur cluster (ISC) assembly complex is activated by frataxin (FXN) and Friedreich’s ataxia is caused by FXN deficiency. Here the authors present the 3.2 Å resolution cryo-EM structure of the human frataxin bound ISC complex and discuss
Externí odkaz:
https://doaj.org/article/8abcf6459af9457bb7545657bbc6ed8d
Autor:
Gabriele Bassi, Nicholas Favalli, Miriam Vuk, Marco Catalano, Adriano Martinelli, Anika Trenner, Antonio Porro, Su Yang, Chuin Lean Tham, Mustafa Moroglu, Wyatt W. Yue, Stuart J. Conway, Peter K. Vogt, Alessandro A. Sartori, Jörg Scheuermann, Dario Neri
Publikováno v:
Advanced Science, Vol 7, Iss 22, Pp n/a-n/a (2020)
Abstract A versatile and Lipinski‐compliant DNA‐encoded library (DEL), comprising 366 600 glutamic acid derivatives coupled to oligonucleotides serving as amplifiable identification barcodes is designed, constructed, and characterized. The GB‐D
Externí odkaz:
https://doaj.org/article/6523af672d2b411ba7e7080f84e45492