Defining predictors of responsiveness to advanced therapies in Crohn's disease and ulcerative colitis: protocol for the IBD-RESPONSE and nested CD-metaRESPONSE prospective, multicentre, observational cohort study in precision medicine.

Autor: Wyatt NJ; Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.; Department of Gastroenterology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Watson H; Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Anderson CA; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Kennedy NA; Department of Gastroenterology, Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK.; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK., Raine T; Department of Gastroenterology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Ahmad T; Department of Gastroenterology, Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK.; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK., Allerton D; Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK., Bardgett M; Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK., Clark E; Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK., Clewes D; Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK., Cotobal Martin C; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Doona M; Department of Gastroenterology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Doyle JA; Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Frith K; Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK., Hancock HC; Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK., Hart AL; Department of Gastroenterology, St Mark's Hospital and Academic Institute, London, UK.; Department of Surgery and Cancer, Imperial College London, London, UK., Hildreth V; Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK., Irving PM; Department of Gastroenterology, Guy's and St Thomas' NHS Foundation Trust, London, UK.; School of Immunology & Microbial Sciences, King's College London, London, UK., Iqbal S; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Kennedy C; Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK., King A; Department of Gastroenterology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Lawrence S; Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK., Lees CW; Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, UK.; Edinburgh IBD Unit, Western General Hospital, NHS Lothian, Edinburgh, UK., Lees R; Department of Gastroenterology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Letchford L; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Liddle T; Research Informatics Team, Clinical Research, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Lindsay JO; Department of Gastroenterology, Barts Health NHS Trust, London, UK.; Centre for Immunobiology, Blizard Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK., Maier RH; Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK., Mansfield JC; Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.; Department of Gastroenterology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Marchesi JR; Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, St Mary's Hospital, Imperial College London, London, UK., McGregor N; Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK., McIntyre RE; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Ostermayer J; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Osunnuyi T; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Powell N; Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, St Mary's Hospital, Imperial College London, London, UK.; Department of Gastroenterology, Imperial College Healthcare NHS Trust, London, UK., Prescott NJ; Department of Medical and Molecular Genetics, Guy's Hospital, King's College London, London, UK., Satsangi J; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Sharma S; Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK., Shrestha T; Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK., Speight A; Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.; Department of Gastroenterology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Strickland M; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Wason JM; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Whelan K; Department of Nutritional Sciences, King's College London, London, UK., Wood R; Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK., Young GR; Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Zhang X; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Parkes M; Department of Gastroenterology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Stewart CJ; Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Jostins-Dean L; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Lamb CA; Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK christopher.lamb@newcastle.ac.uk.; Department of Gastroenterology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.

Publikováno v: BMJ open [BMJ Open] 2024 Apr 17; Vol. 14 (4), pp. e073639. Date of Electronic Publication: 2024 Apr 17.

Phytoplankton responses to dust addition in the Fe-Mn co-limited eastern Pacific sub-Antarctic differ by source region.

Autor: Wyatt NJ; School of Ocean and Earth Science, National Oceanography Centre Southampton, University of Southampton, Southampton SO14 3ZH, United Kingdom.; School of Geography, Earth and Environmental Sciences, University of Plymouth, Plymouth PL4 8AA, United Kingdom., Birchill A; School of Geography, Earth and Environmental Sciences, University of Plymouth, Plymouth PL4 8AA, United Kingdom., Ussher S; School of Geography, Earth and Environmental Sciences, University of Plymouth, Plymouth PL4 8AA, United Kingdom., Milne A; School of Geography, Earth and Environmental Sciences, University of Plymouth, Plymouth PL4 8AA, United Kingdom., Bouman HA; Department of Earth Sciences, University of Oxford, Oxford OX1 2JD, United Kingdom., Shoenfelt Troein E; Department of Earth, Atmospheric and Planetary Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139., Pabortsava K; National Oceanography Centre, Southampton SO14 3ZH, United Kingdom., Wright A; School of Ocean and Earth Science, National Oceanography Centre Southampton, University of Southampton, Southampton SO14 3ZH, United Kingdom., Flanagan O; School of Ocean and Earth Science, National Oceanography Centre Southampton, University of Southampton, Southampton SO14 3ZH, United Kingdom., Bibby TS; School of Ocean and Earth Science, National Oceanography Centre Southampton, University of Southampton, Southampton SO14 3ZH, United Kingdom., Martin A; National Oceanography Centre, Southampton SO14 3ZH, United Kingdom., Moore CM; School of Ocean and Earth Science, National Oceanography Centre Southampton, University of Southampton, Southampton SO14 3ZH, United Kingdom.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Jul 11; Vol. 120 (28), pp. e2220111120. Date of Electronic Publication: 2023 Jul 03.