Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Wyatt J. Roth"'
Autor:
Mike Tobyn, Angela Olsofsky, Sayantan Chattoraj, Wyatt J. Roth, Patrick David Daugherity, Todd McDermott
Publikováno v:
Journal of Pharmaceutical Sciences. 107:2267-2282
Sticking and picking during tablet manufacture has received increasing interest recently, as it causes tablet defects, downtime in manufacturing, and yield losses. The capricious nature of the problem means that it can appear at any stage of the deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c4ccf2247a8891f156a0c24b4a20420
https://doi.org/10.1016/j.xphs.2018.04.029
https://doi.org/10.1016/j.xphs.2018.04.029
Publikováno v:
Journal of pharmaceutical sciences. 106(5)
The purpose of this work was to assess the impact of continuous mixing on tablet critical quality attributes (CQAs) manufactured using a continuous, direct compression process. A 9-run design of experiments (DoE) that bracketed the range of commercia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea60fe475a8c0e47800528f373f7e4dc
https://pubmed.ncbi.nlm.nih.gov/28153598
https://pubmed.ncbi.nlm.nih.gov/28153598
Publikováno v:
Frontiers in Genetics, Vol 5 (2014)
Frontiers in Genetics
Frontiers in Genetics
The development of new therapeutic agents for the mitigation of pediatric disorders is largely hindered by the inability for investigators to assess pediatric pharmacokinetics (PK) in healthy patients due to substantial safety concerns. Pediatric pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::038d085d83bf40420287e3b2c60ca372
Autor:
Rachel C. Vreeman, Wyatt J. Roth, Sophia Hannou, Jeremy N. Marchant-Forde, Gregory T. Knipp, Bruce R. Cooper, Robyn R. McCain, Candice B. Kissinger
Pediatric drug development is hampered by biological, clinical, and formulation challenges associated with age-based populations. A primary cause for this lack of development is the inability to accurately predict ontogenic changes that affect pharma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e5469253ad309a5eb81577af5f125dd
https://europepmc.org/articles/PMC3691418/
https://europepmc.org/articles/PMC3691418/
Expression and function of drug transporters and drug‐metabolizing enzymes (DMEs) in the gastrointestinal tract are critical attributes of intestinal physiology that influence the absorption of orally administered compounds. The purpose of this stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0220e1b8c0e9f789f2a3ab6287b1c089
https://europepmc.org/articles/PMC4547930/
https://europepmc.org/articles/PMC4547930/
Publikováno v:
Journal of pharmaceutical sciences. 101(4)
The HT-29 cell line forms a confluent monolayer with tight junctions, but displays different phenotypes when cultured for 21 days in galactose-supplemented media (differentiated) versus glucose-supplemented media (dedifferentiated). This study is aim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e21021209d911488d695ac0fd097853d
https://pubmed.ncbi.nlm.nih.gov/22213613
https://pubmed.ncbi.nlm.nih.gov/22213613
Autor:
Jean-Michel Kauffmann, Karim Amighi, Wyatt J. Roth, Jonathan Goole, Stephen M. Carl, David J. Lindley, Gregory T. Knipp
Publikováno v:
International journal of pharmaceutics. 393(1-2)
Traditionally most pharmaceutical excipients used for peroral dosage forms have been considered to be inert, although they have been known to play an important role in governing the release of the active pharmaceutical ingredient (API) required for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7830fa19c3538a76bcc76b31eb21b429
https://pubmed.ncbi.nlm.nih.gov/20417699
https://pubmed.ncbi.nlm.nih.gov/20417699