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Secretion of the Shiga toxin B subunit (Stx1B) via an autotransporter protein optimizes the protective immune response to the antigen expressed in an attenuated E. coli (rEPEC E22Δler) vaccine strain

Autor: Edgar C. Boedeker, Chengru Zhu, Wyatt Byrd, Prashanth Setty, Fernando Ruiz-Perez

Publikováno v: Veterinary Microbiology. 211:180-188

We previously developed attenuated rabbit enteropathogenic E. coli (rEPEC) strains which are effective oral vaccines against their parent pathogens by deleting le r, a global regulator of virulence genes. To use these strains as orally administered v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f22246f87a34aedf124048eb1b916b92
https://doi.org/10.1016/j.vetmic.2017.10.006

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Attenuated Escherichia coli strains expressing the colonization factor antigen I (CFA/I) and a detoxified heat-labile enterotoxin (LThK63) enhance clearance of ETEC from the lungs of mice and protect mice from intestinal ETEC colonization and LT-induced fluid accumulation

Autor: Edgar C. Boedeker, Wyatt Byrd

Publikováno v: Veterinary Immunology and Immunopathology. 152:57-67

Although enterotoxigenic Escherichia coli (ETEC) infections are important causes of infantile and traveler's diarrhea there is no licensed vaccine available for those at-risk. Our goal is to develop a safe, live attenuated ETEC vaccine. We used an at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::260a90f82835489a5dcaf7071c59bbf9
https://doi.org/10.1016/j.vetimm.2012.10.001

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A directed intimin insertion mutant of a rabbit enteropathogenic Escherichia coli (REPEC) is attenuated, immunogenic and elicits serogroup specific protection

Autor: Wyatt Byrd, Sudeep Kumar, Edgar C. Boedeker, Sibtain Ahmed

Publikováno v: Veterinary Immunology and Immunopathology. 152:146-155

We previously showed ( Agin et al., 2005 ) that a truncated beta-intimin mutant of an O15 A/E REPEC strain, which does not contain the C terminal tir binding region of intimin but expresses the preceding immunodominant portion of the molecule in oute

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d1a557bb6a228a91ece3b4935f3d845
https://doi.org/10.1016/j.vetimm.2012.09.035

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The secreted effector protein EspZ is essential for virulence of rabbit enteropathogenic Escherichia coli

Autor: Edgar C. Boedeker, Wyatt Byrd, John Scott Wilbur, Hannah E. Ledvina, Gayatri Vedantam, Michael W. Riggs, V. K. Viswanathan, Shylaja Ramamurthy, Khaldoon Khirfan

Publikováno v: Infection and immunity. 83(3)

Attaching and effacing (A/E) pathogens adhere intimately to intestinal enterocytes and efface brush border microvilli. A key virulence strategy of A/E pathogens is the type III secretion system (T3SS)-mediated delivery of effector proteins into host

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3a464a55740218a2414ea3cb4188d63
https://pubmed.ncbi.nlm.nih.gov/25561713

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Mucosal immunization of BALB/c mice using enterotoxigenic Escherichia coli colonization factors CFA/I and CS6 administered with and without a mutant heat-labile enterotoxin

Autor: Frederick J. Cassels, Wyatt Byrd

Publikováno v: Vaccine. 21:1884-1893

Mice (BALB/c) were intranasally (IN) and intragastrically (IG) administered the ETEC colonization factors (CF), CFA/I and CS6, with and without the R192G mutant heat-labile enterotoxin (mLT), and immunogenicity and efficacy measured. The IN administr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19c73b0a2eb84a285a1289063c993c72
https://doi.org/10.1016/s0264-410x(03)00014-8

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Temperature-sensitive mutants of Actinobacillus pleuropneumoniae induce protection in mice

Autor: Anne Morris Hooke, Wyatt Byrd

Publikováno v: Infection and Immunity. 65:2206-2210

Temperature-sensitive mutants of Actinobacillus pleuropneumoniae 4074, serotype 1, were isolated after treatment with nitrosoguanidine and enrichment with penicillin and D-cycloserine. Of the four temperature-sensitive mutants evaluated in mice, one

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4038ba116c967b36943ad35f0a0ecb7d
https://doi.org/10.1128/iai.65.6.2206-2210.1997

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Virulence inhibition by zinc in shiga-toxigenic Escherichia coli

Autor: Edgar C. Boedeker, John K. Crane, Isaac Wyatt Byrd

Publikováno v: Infection and immunity. 79(4)

Previously, our laboratories reported that zinc inhibited expression of several important virulence factors in enteropathogenic Escherichia coli (EPEC) and reduced EPEC-induced intestinal damage in vivo . Since EPEC is genetically related to Shiga-to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e6a03079713324a8277dfcb27f22ad5
https://pubmed.ncbi.nlm.nih.gov/21245267

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Protective efficacy of conjugate vaccines against experimental challenge with porcine Actinobacillus pleuropneumoniae

Autor: S Kadis, Wyatt Byrd, Barry G. Harmon

Publikováno v: Veterinary Immunology and Immunopathology. 34:307-324

In an attempt to protect pigs against swine pleuropneumonia induced by Actinobacillus pleuropneumoniae (SPAP) by neutralizing the effects of three virulence factors of A. pleuropneumoniae--the capsular polysaccharide (CP), the lipopolysaccharide (LPS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0151b5826c49d2de20594dedefd73e2a
https://doi.org/10.1016/0165-2427(92)90172-m

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The encapsulation of enterotoxigenic Escherichia coli colonization factor CS3 in biodegradable microspheres enhances the murine antibody response following intranasal administration

Autor: Frederick J. Cassels, Wyatt Byrd

Publikováno v: Microbiology (Reading, England). 152(Pt 3)

The aim of this study was to measure serum and mucosal antibody responses following intranasal administration of biodegradable poly(dl-lactide-co-glycolide) (PLGA) microspheres loaded with the CS3 colonization factor isolated from enterotoxigenicEsch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff6dcb6ad5203a3eec1ab0266f72d81e
https://pubmed.ncbi.nlm.nih.gov/16514157

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