Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Wuxiyar Otkur"'
Autor:
Yawei Wang, Di Chen, Yu Liu, Daiwang Shi, Chao Duan, Jinghan Li, Xiang Shi, Yong Zhang, Zhanwu Yu, Nan Sun, Wei Wang, Yegang Ma, Xiaohan Xu, Wuxiyar Otkur, Xiaolong Liu, Tian Xia, Huan Qi, Hai-long Piao, Hong-Xu Liu
Publikováno v:
Cell Death and Disease, Vol 14, Iss 7, Pp 1-16 (2023)
Abstract Multiple primary lung cancers (MPLCs) pose diagnostic and therapeutic challenges in clinic. Here, we orchestrated the cellular and spatial architecture of MPLCs by combining single-cell RNA-sequencing and spatial transcriptomics. Notably, we
Externí odkaz:
https://doaj.org/article/437bea4b8caa4c69bb243ec2c2f6744e
Autor:
Wuxiyar Otkur, Xiaolong Liu, Huan Chen, Siyi Li, Ting Ling, Hanchen Lin, Renyu Yang, Tian Xia, Huan Qi, Hai-Long Piao
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background and purpose: GPR35, a member of the orphan G-protein-coupled receptor, was recently implicated in colorectal cancer (CRC). However, whether targeting GPR35 by antagonists can inhibit its pro-cancer role has yet to be answered.Experimental
Externí odkaz:
https://doaj.org/article/d8d3f62a5eab4ece9a2bdea4fa48593b
Autor:
Chibuzo Sampson, Qiuping Wang, Wuxiyar Otkur, Haifeng Zhao, Yun Lu, Xiaolong Liu, Hai‐long Piao
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 3, Pp n/a-n/a (2023)
Abstract Ubiquitination is one of the most important post‐translational modifications which plays a significant role in conserving the homeostasis of cellular proteins. In the ubiquitination process, ubiquitin is conjugated to target protein substr
Externí odkaz:
https://doaj.org/article/ea82d39736a347f7b02784acd338036c
Autor:
Zhen Ning, Xin Guo, Xiaolong Liu, Chang Lu, Aman Wang, Xiaolin Wang, Wen Wang, Huan Chen, Wangshu Qin, Xinyu Liu, Lina Zhou, Chi Ma, Jian Du, Zhikun Lin, Haifeng Luo, Wuxiyar Otkur, Huan Qi, Di Chen, Tian Xia, Jiwei Liu, Guang Tan, Guowang Xu, Hai-long Piao
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Different deubiquitinases are associated to cancer development. Here, the authors show that PPARgamma is stabilized by USP22-mediated deubiquitination leading to lipid accumulation and promoting hepatocellular carcinoma.
Externí odkaz:
https://doaj.org/article/7a0b38d3c50c4e26bad4fb004f16686a
Autor:
Tian Xia, Di Chen, Xiaolong Liu, Huan Qi, Wen Wang, Huan Chen, Ting Ling, Wuxiyar Otkur, Chen-Song Zhang, Jongchan Kim, Sheng-Cai Lin, Hai-long Piao
Publikováno v:
Cell Death and Disease, Vol 13, Iss 4, Pp 1-13 (2022)
Abstract Midkine (MDK), a secreted growth factor, regulates signal transduction and cancer progression by interacting with receptors, and it can be internalized into the cytoplasm by endocytosis. However, its intracellular function and signaling regu
Externí odkaz:
https://doaj.org/article/c2fb9973122349a3bcf3f95666dab8f3
Autor:
Xiumei Liu, Di Chen, Huan Chen, Wen Wang, Yu Liu, Yawei Wang, Chao Duan, Zhen Ning, Xin Guo, Wuxiyar Otkur, Jing Liu, Huan Qi, Xiaolong Liu, Aifu Lin, Tian Xia, Hong‐xu Liu, Hai‐long Piao
Publikováno v:
Cancer Communications, Vol 41, Iss 7, Pp 576-595 (2021)
Abstract Background Y‐box binding protein 1 (YB1 or YBX1) plays a critical role in tumorigenesis and cancer progression. However, whether YB1 affects malignant transformation by modulating non‐coding RNAs remains largely unknown. This study aimed
Externí odkaz:
https://doaj.org/article/61870f4567954b3baf8ca43784ba8483
Autor:
Lei Wang, Wuxiyar Otkur, Aman Wang, Wen Wang, Yitong Lyu, Lei Fang, Xiu Shan, Mingzhou Song, Yan Feng, Yi Zhao, Hai-Long Piao, Huan Qi, Ji-Wei Liu
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Melanoma is the most aggressive type of skin cancer with a high incidence and low survival rate. More than half of melanomas present the activating BRAF mutations, along which V600E mutant represents 70%–90%. Vemurafenib (Vem) is an FDA-approved sm
Externí odkaz:
https://doaj.org/article/eeefd80a7dfe413293aaf6dcbcacfdb9
Autor:
Di Chen, Yiran Zhang, Wen Wang, Huan Chen, Ting Ling, Renyu Yang, Yawei Wang, Chao Duan, Yu Liu, Xin Guo, Lei Fang, Wuguang Liu, Xiumei Liu, Jing Liu, Wuxiyar Otkur, Huan Qi, Xiaolong Liu, Tian Xia, Hong‐Xu Liu, Hai‐long Piao
Publikováno v:
Advanced Science, Vol 8, Iss 17, Pp n/a-n/a (2021)
Abstract Metabolite‐protein interactions (MPIs) play key roles in cancer metabolism. However, our current knowledge about MPIs in cancers remains limited due to the complexity of cancer cells. Herein, the authors construct an integrative MPI networ
Externí odkaz:
https://doaj.org/article/9ce71e8a9cb843a797dbaf101dacd7c4
Autor:
Wei-Wei, Liu, Fang, Wang, Can, Li, Xiao-Yu, Song, Wuxiyar, Otkur, Yu-Ying, Zhu, Toshihiko, Hayashi, Kazunori, Mizuno, Shunji, Hattori, Hitomi, Fujisaki, Takashi, Ikejima
Publikováno v:
Acta Pharmacologica Sinica. 43:2156-2167
Excessive exposure to UVB induces skin diseases. Silibinin, a flavonolignan used for treating liver diseases, is found to be effective against UVB-caused skin epidermal and dermal cell damage. In this study we investigated the molecular mechanisms un
Autor:
Wuxiyar Otkur, Jixia Wang, Tao Hou, Fan Liu, Renyu Yang, Yirong Li, Kaijing Xiang, Shaojun Pei, Huan Qi, Hanchen Lin, Han Zhou, Xiuli Zhang, Hai-long Piao, Xinmiao Liang
Publikováno v:
European Journal of Pharmacology. 949:175719