Mechanism of biomolecular recognition of trimethyllysine by the fluorinated aromatic cage of KDM5A PHD3 finger.

Autor: Pieters BJGE; Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands., Wuts MHM; Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands., Poater J; ICREA and Departament de Química Inorgànica i Orgànica & IQTCUB, Universitat de Barcelona, Martí i Franquès 1-11, 08028, Barcelona, Spain., Kumar K; Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, OX1 3TA, Oxford, UK., White PB; Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands., Kamps JJAG; Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands., Sherman W; Schrӧdinger, Inc., 120 West 45th Street, New York, NY, 10036, USA.; Silicon Therapeutics, 451 D St., Boston, MA, 02210, USA., Pruijn GJM; Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands.; Radboud Institute for Molecular Life Sciences, Radboud University, Geert Grooteplein Zuid 26-28, 6525 GA, Nijmegen, The Netherlands., Paton RS; Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, OX1 3TA, Oxford, UK., Beuming T; Schrӧdinger, Inc., 120 West 45th Street, New York, NY, 10036, USA.; Latham Biopharm Group 101 Main Street, Suite 1400 Cambridge, MA, 02142, USA., Bickelhaupt FM; Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands.; Department of Theoretical Chemistry and Amsterdam Center for Multiscale Modeling, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands., Mecinović J; Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands. mecinovic@sdu.dk.; Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, 5230, Odense, Denmark. mecinovic@sdu.dk.

Publikováno v: Communications chemistry [Commun Chem] 2020 Jun 01; Vol. 3 (1), pp. 69. Date of Electronic Publication: 2020 Jun 01.