Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Wuqing Deng"'
Autor:
Fang Yang, Xiaojuan Chen, Xiaojuan Song, Raquel Ortega, Xiaojing Lin, Wuqing Deng, Jing Guo, Zhengchao Tu, Adam V. Patterson, Jeff B. Smaill, Yongheng Chen, Xiaoyun Lu
Publikováno v:
Journal of Medicinal Chemistry. 65:14809-14831
Autor:
Fang, Yang, Xiaojuan, Chen, Xiaojuan, Song, Raquel, Ortega, Xiaojing, Lin, Wuqing, Deng, Jing, Guo, Zhengchao, Tu, Adam V, Patterson, Jeff B, Smaill, Yongheng, Chen, Xiaoyun, Lu
Publikováno v:
Journal of medicinal chemistry. 65(21)
The FGF19-FGFR4 signaling pathway has been extensively studied as a promising target for the treatment of hepatocellular carcinoma (HCC). Several FGFR4-selective inhibitors have been developed, but none of them receives approval. Additionally, acquir
Autor:
Zhengchao Tu, Jiang Kaili, Xiaoyun Lu, Xiaojing Lin, Raquel Ortega, Adam V. Patterson, Yongheng Chen, Zhang Zhang, Jeff B. Smaill, Minhao Huang, Xiaojuan Chen, Ke Ding, Xiaojuan Song, Suming Chen, Wuqing Deng
Publikováno v:
ACS Med Chem Lett
[Image: see text] Covalent kinase inhibitors are rapidly emerging as a class of therapeutics with clinical benefits. Herein we report a series of selective 2-aminopyrimidine-based fibroblast growth factor receptor 4 (FGFR4) inhibitors exploring diffe