Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Wun-Chang Ko"'
Autor:
Li-Wen Chen, Wun-Chang Ko
Publikováno v:
Medicine in Drug Discovery, Vol 12, Iss , Pp 100106- (2021)
Quercetin and isoquercitrin were reported to have anti-inflammatory effects on typical asthma. Therefore, we investigated quercetin-3-O-glycosides to clarify the potential for treating atypical asthma. The inhibitions of quercetin-3-O-glycosides on P
Externí odkaz:
https://doaj.org/article/29cb7ee0179148939de76193111bc29f
Publikováno v:
Pharmaceutical Biology, Vol 57, Iss 1, Pp 380-384 (2019)
Context: Butylidenephthalide (Bdph) has been reported to inhibit rat uterine contractions, but significantly potentiate the noradrenaline (NA)-induced contractions in guinea-pig vas deferens (GPVDs). Objective: The present study elucidates the bindin
Externí odkaz:
https://doaj.org/article/a8adf0e772d2433eae8cbc64f156518e
Publikováno v:
Pharmaceutical Biology, Vol 56, Iss 1, Pp 378-384 (2018)
Context: The rhizome of Ligusticum chuaxiong Hort. (Umbelliferae) has been used by Chinese for several thousand years. Its main constituent, butylidenephthalide (Bdph), was proved to be active in inhibiting rat uterine contractions induced by prostag
Externí odkaz:
https://doaj.org/article/e9cf2919a63f42db97ece4db6189d299
Publikováno v:
BMC Pharmacology and Toxicology, Vol 18, Iss 1, Pp 1-7 (2017)
Abstract Background We recently reported that hesperetin-5,7,3’-O-triacetate (HTA) dually inhibited phosphodiesterase (PDE)3/4 with a therapeutic ratio of 20.8. The application and development of PDE4 inhibitors for treating asthma or COPD are limi
Externí odkaz:
https://doaj.org/article/d3efc0917d904a798ad2f20165371941
Publikováno v:
Drug Design, Development and Therapy. 14:519-526
Introduction Hesperetin-5,7,3'-O-trimethylether (HTME), a synthetic liposoluble hesperetin, has been reported to be a dual phosphodiesterase (PDE)3/4 inhibitor. We investigated its inhibitory effects on methacholine (MCh)-induced airway hyperresponsi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19d9dfa26bdcc4945fe12bab3a0217fe
https://doi.org/10.2147/dddt.s227432
https://doi.org/10.2147/dddt.s227432
Autor:
Wun-Chang Ko, Li-Wen Chen
Publikováno v:
Medicine in Drug Discovery, Vol 12, Iss, Pp 100106-(2021)
Quercetin and isoquercitrin were reported to have anti-inflammatory effects on typical asthma. Therefore, we investigated quercetin-3-O-glycosides to clarify the potential for treating atypical asthma. The inhibitions of quercetin-3-O-glycosides on P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::970cfa844806db5e710a75450520a050
https://doi.org/10.1016/j.medidd.2021.100106
https://doi.org/10.1016/j.medidd.2021.100106
Autor:
Wun-Chang Ko, Junn-Lain Chen
Publikováno v:
European Journal of Pharmacology. 811:129-133
Apigenin, was reported to have vasodilatory effects by inhibiting Ca2+ influx through both voltage- and receptor-operated calcium channels, but not by inhibiting cAMP- or cGMP-phosphodiesterases (PDEs) in rat thoracic aorta. However, apigenin was rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92dffd481cd7e240e0edd5a8d92004d4
https://doi.org/10.1016/j.ejphar.2017.06.014
https://doi.org/10.1016/j.ejphar.2017.06.014
Publikováno v:
BMC Pharmacology and Toxicology, Vol 18, Iss 1, Pp 1-7 (2017)
BMC Pharmacology & Toxicology
BMC Pharmacology & Toxicology
Background We recently reported that hesperetin-5,7,3’-O-triacetate (HTA) dually inhibited phosphodiesterase (PDE)3/4 with a therapeutic ratio of 20.8. The application and development of PDE4 inhibitors for treating asthma or COPD are limited by th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8251f8e992074b43e02b9c92587ee326
http://link.springer.com/article/10.1186/s40360-017-0146-5
http://link.springer.com/article/10.1186/s40360-017-0146-5
Publikováno v:
Drug Design, Development and Therapy
Introduction Hesperetin-5,7,3ʹ-O-trimethylether (HTME), a synthetic liposoluble hesperetin, has been reported to be a dual phosphodiesterase (PDE)3/4 inhibitor. We investigated its inhibitory effects on methacholine (MCh)-induced airway hyperrespons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::26d3e691d6169c90c3946d7ce80239f4
https://pubmed.ncbi.nlm.nih.gov/32099334
https://pubmed.ncbi.nlm.nih.gov/32099334
Autor:
Wun Chang Ko, Marcelo Chen
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 389:159-166
Z-Butylidenephthalide (Bdph) was reported to more potently inhibit electrically induced twitch responses than acetylcholine-induced tonic contraction in isolated guinea-pig ileum (GPI). The aim of the present study was to investigate the inhibitory e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::864b211f3ad723a594506eb876e2ed77
https://doi.org/10.1007/s00210-015-1183-5
https://doi.org/10.1007/s00210-015-1183-5