Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Wun Chey Sin"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Angiotensin-converting enzyme II (ACE2) is a monocarboxypeptidase expressed throughout multiple tissues and its catalysis of bioactive peptides regulates the renin-angiotensin system mediating blood pressure homeostasis. ACE2 is implicated i
Externí odkaz:
https://doaj.org/article/ddf2c4d670de4062ba736ae72016e9aa
Autor:
Yuji Kajiwara, Erming Wang, Minghui Wang, Wun Chey Sin, Kristen J. Brennand, Eric Schadt, Christian C. Naus, Joseph Buxbaum, Bin Zhang
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-20 (2018)
Abstract GJA1 (connexin43) has been predicted as the top key driver of an astrocyte enriched subnetwork associated with Alzheimer’s disease (AD). In this study, we comprehensively examined GJA1 expression across 29 transcriptomic and proteomic data
Externí odkaz:
https://doaj.org/article/977690558e094e1a87219300ec7b9707
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 15, p 5216 (2020)
The environment that envelops the cancer cells intimately affects the malignancy of human cancers. In the case of glioma, an aggressive adult brain cancer, its high rate of recurrence after total resection is responsible for a poor prognosis. Connexi
Externí odkaz:
https://doaj.org/article/b19f3607440d4cb5a2d8afecdce0ddd3
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 4, p 1159 (2018)
The tumor microenvironment is known to have increased levels of cytokines and metabolites, such as glutamate, due to their release from the surrounding cells. A normal cell around the tumor that responds to the inflammatory environment is likely to b
Externí odkaz:
https://doaj.org/article/4666631360374604bb2cc63c2d45493a
Autor:
Rocío Talaverón, Arantxa Tabernero, Andrea Álvarez-Vázquez, Wun Chey Sin, Raquel Flores-Hernández, Sara G. Pelaz, José M. Medina, Laura García-Vicente, Christian C. Naus, Myriam Jaraíz-Rodríguez, Marta Domínguez-Prieto, John F. Bechberger
Publikováno v:
Neuro-Oncology
Background Malignant gliomas are the most frequent primary brain tumors and remain among the most incurable cancers. Although the role of the gap junction protein, connexin43 (Cx43), has been deeply investigated in malignant gliomas, no compounds hav
Autor:
Warren M. Meyers, Sanja Rogic, Iulia Dascalu, Daniel B. Callaghan, Wei Wj, Fabian Meili, Kurt Haas, Wun Chey Sin, Paul Pavlidis
SYNGAP1 is a Ras and Rap GTPase with important roles in regulating excitatory synaptic plasticity. While manySYNGAP1missense and nonsense mutations have been associated with intellectual disability, epilepsy, schizophrenia and autism spectrum disorde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b733934ca22b2d2060adbdba96d9bd1
https://doi.org/10.1101/2020.04.21.053686
https://doi.org/10.1101/2020.04.21.053686
Autor:
Daniel B. Callaghan, William J. Wei, Sanja Rogic, Warren M. Meyers, Kurt Haas, Fabian Meili, Iulia Dascalu, Paul Pavlidis, Wun Chey Sin
Publikováno v:
Am J Hum Genet
Summary SYNGAP1 is a neuronal Ras and Rap GTPase-activating protein with important roles in regulating excitatory synaptic plasticity. While many SYNGAP1 missense and nonsense mutations have been associated with intellectual disability, epilepsy, sch
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 5216, p 5216 (2020)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
The environment that envelops the cancer cells intimately affects the malignancy of human cancers. In the case of glioma, an aggressive adult brain cancer, its high rate of recurrence after total resection is responsible for a poor prognosis. Connexi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ac0996acb26297e37f31b29c4604799
Publikováno v:
Journal of Cell Communication and Signaling. 12:723-730
Glioma is a highly aggressive form of brain cancer, with some subtypes having 5-year survival rates of less than 5%. Tumour cell invasion into the surrounding parenchyma seems to be the primary driver of these poor outcomes, as most gliomas recur wit
Autor:
Leonard J. Foster, Pierre-Olivier Strale, Marc Mesnil, Wun-Chey Sin, Jenna Noordenbos, Vincent C. Chen, Alisha T Poole, Christian C. Naus, Qurratulain Aftab, Caitlin Le, Emmanuel Ojefua, Chris Sitko, Nikolay Stoynov
Publikováno v:
Frontiers in Neuroscience
Frontiers in Neuroscience, Frontiers, 2019, 13, ⟨10.3389/fnins.2019.00143⟩
Frontiers in Neuroscience, Vol 13 (2019)
Frontiers in Neuroscience, Frontiers, 2019, 13, ⟨10.3389/fnins.2019.00143⟩
Frontiers in Neuroscience, Vol 13 (2019)
Extracellular matrix (ECM) remodeling, degradation and glioma cell motility are critical aspects of glioblastoma multiforme (GBM). Despite being a rich source of potential biomarkers and targets for therapeutic advance, the dynamic changes occurring