Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Wuming Yan"'
Publikováno v:
Analytical Methods. 15:1054-1061
Quantitation of DMT-OH and six small molecule impurities in various oligonucleotide matrices is enabled by a high throughput LC-MS/MS method.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1133ae5624a1d04f63fb5f40dd7a0428
https://doi.org/10.1039/d2ay02020c
https://doi.org/10.1039/d2ay02020c
Autor:
Robert S. Gronke, Yannick Fillon, William F. Kiesman, Wuming Yan, Armin Delavari, Xuan Zhou, Li Xiao, Jing Yang, Hong Jiang, Firoz D. Antia, Xianglin Shi
The recent explosive growth in the number of oligonucleotide clinical development programs and drug approvals underscores their ability to treat diseases via mRNA regulation. Currently, solid-supported synthesis is limited to ≤ 5 kg (~ 1 mole) batc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c6498ee12b65a5e24a7c70aac319e21
https://doi.org/10.21203/rs.3.rs-594481/v1
https://doi.org/10.21203/rs.3.rs-594481/v1
Autor:
Xuan Zhou, Kiesman, William F., Wuming Yan, Hong Jiang, Antia, Firoz D., Jing Yang, Fillon, Yannick A., Li Xiao, Xianglin Shi
Publikováno v:
Journal of Organic Chemistry; 2/18/2022, Vol. 87 Issue 4, p2087-2110, 24p
Publikováno v:
Journal of the American Chemical Society. 137:6219-6225
The C1-C19 building block 46 of halichondrin Bs was synthesized via a selective activation/coupling of β-bromoenone 34 with aldehyde 35 in a Ni/Cr-mediated reaction. The first phase of study was a method development to effect a coupling of a "naked"
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2f7d70f9dd36c6684cce0d6a57b572e
https://doi.org/10.1021/jacs.5b03498
https://doi.org/10.1021/jacs.5b03498
Publikováno v:
Journal of the American Chemical Society. 137:6226-6231
A unified synthesis of the C1-C19 building blocks 8-10 of halichondrins A-C was developed from the common synthetic intermediates 26a,b. Acetylenic ketones 26a,b were in turn synthesized via selective activation/coupling of polyhalogenated nucleophil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f32dfcc94714fcb79809e9d459fa4952
https://doi.org/10.1021/jacs.5b03499
https://doi.org/10.1021/jacs.5b03499
Publikováno v:
Asian Journal of Organic Chemistry. 2:904-914
Secondary amines, the well-known enamine and iminium catalysts, can also be used as Lewis bases for the activation of electron-deficient olefins. In this Focus Review, a series of systematic studies from the last five years on activation of nitroolef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9714cad788df42dfcde7e4fe63500bf8
https://doi.org/10.1002/ajoc.201300048
https://doi.org/10.1002/ajoc.201300048
Autor:
Wuming Yang, Zhijia Tian
Publikováno v:
The Astrophysical Journal, Vol 970, Iss 1, p 38 (2024)
The ratio of metal abundance to hydrogen abundance of the solar photosphere, ( Z / X ) _s , has been revised several times. Standard solar models, based on these revised solar abundances, are in disagreement with seismically inferred results. Recentl
Externí odkaz:
https://doaj.org/article/62e57887f9284372a3b8e7dcd7c9cca5
Publikováno v:
Chemistry - An Asian Journal. 6:2720-2724
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe572c6ab4d3da68e3d1f27422f4aaad
https://doi.org/10.1002/asia.201100357
https://doi.org/10.1002/asia.201100357
Publikováno v:
Chemistry - A European Journal. 17:5011-5018
The N-2-aryl-1,2,3-triazole derivatives (NATs) were developed as a new class of UV/blue-light-emitting fluorophores. Though both N-1-aryl-1,2,3-triazoles and N-2-aryl-1,2,3-triazoles gave strong photo absorption under excitation at 330 nm, only the N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a8193626b2a2c5502d9b88ce9269080
https://doi.org/10.1002/chem.201002937
https://doi.org/10.1002/chem.201002937