Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Wuming, Gong"'
Autor:
Il-Youp Kwak, Byeong-Chan Kim, Juhyun Lee, Taein Kang, Daniel J. Garry, Jianyi Zhang, Wuming Gong
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-13 (2024)
Abstract The breakthrough high-throughput measurement of the cis-regulatory activity of millions of randomly generated promoters provides an unprecedented opportunity to systematically decode the cis-regulatory logic that determines the expression va
Externí odkaz:
https://doaj.org/article/0af5c93b8a9a47479bfdcf64431a6871
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-28 (2023)
Abstract Assay for Transposase-Accessible Chromatin with sequencing (ATAC-seq) reveals chromatin accessibility across the genome. Currently, no method specifically detects differential chromatin accessibility. Here, SeATAC uses a conditional variatio
Externí odkaz:
https://doaj.org/article/d56d0fbeef97442287bbd3c39241eadc
Autor:
Naoko Koyano-Nakagawa, Wuming Gong, Satyabrata Das, Joshua W. M. Theisen, Tran B. Swanholm, Daniel Van Ly, Nikita Dsouza, Bhairab N. Singh, Hiroko Kawakami, Samantha Young, Katherine Q. Chen, Yasuhiko Kawakami, Daniel J. Garry
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The embryonic limb bud is known to be patterned by a Shh morphogen gradient, though how Shh expression is activated remains less clear. Here the authors show that Etv2 acts as a pioneer transcription factor to mediate accessibility of the ZRS enhance
Externí odkaz:
https://doaj.org/article/78037045b7d940fa8cf10e68eb7f55dd
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-14 (2022)
Abstract Background DCLEAR is an R package used for single cell lineage reconstruction. The advances of CRISPR-based gene editing technologies have enabled the prediction of cell lineage trees based on observed edited barcodes from each cell. However
Externí odkaz:
https://doaj.org/article/689f5a5067d742eb825770955795380d
Publikováno v:
Biology, Vol 12, Iss 10, p 1291 (2023)
In this study, we constructed a model to predict abnormal cardiac sounds using a diverse set of auscultation data collected from various auscultation positions. Abnormal heart sounds were identified by extracting features such as peak intervals and n
Externí odkaz:
https://doaj.org/article/91c8c9e2ddfa49119c0aebbd2bd74f0e
Autor:
Satyabrata Das, Vinayak Gupta, Johannes Bjorge, Xiaozhong Shi, Wuming Gong, Mary G. Garry, Daniel J. Garry
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Ets variant 2 (Etv2), a member of the Ets factor family, has an essential role in the formation of endothelial and hematopoietic cell lineages during embryonic development. The functional role of ETS transcription factors is, in part, dependent on th
Externí odkaz:
https://doaj.org/article/ab072e7171734121a591fca05cfc9b52
Autor:
Bhairab N. Singh, Wuming Gong, Satyabrata Das, Joshua W. M. Theisen, Javier E. Sierra-Pagan, Demetris Yannopoulos, Erik Skie, Pruthvi Shah, Mary G. Garry, Daniel J. Garry
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Abstract Etv2, an Ets-transcription factor, governs the specification of the earliest hemato-endothelial progenitors during embryogenesis. While the transcriptional networks during hemato-endothelial development have been well described, the mechanis
Externí odkaz:
https://doaj.org/article/eda0d5c70def493b993477499d9dd848
Autor:
Bhairab N. Singh, Naoko Koyano-Nakagawa, Wuming Gong, Ivan P. Moskowitz, Cyprian V. Weaver, Elizabeth Braunlin, Satyabrata Das, Jop H. van Berlo, Mary G. Garry, Daniel J. Garry
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
Due to the limited proliferation capacity of adult mammalian cardiomyocytes, the human heart has negligible regenerative capacity after injury. Here the authors show that a Hedgehog-Gli1-Mycn signaling cascade regulates cardiomyocyte proliferation an
Externí odkaz:
https://doaj.org/article/e834b139d7d24de2a7e908969edba69b
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
Time series single cell expression data has large variance between time points and is challenging for analysis. Here, the authors develop a new dimension reduction and data visualization tool for large scale temporal scRNA-seq data which identifies t
Externí odkaz:
https://doaj.org/article/3107b11735c5411d8a8c981b9ffc4189
Publikováno v:
BMC Bioinformatics, Vol 19, Iss 1, Pp 1-10 (2018)
Abstract Background The single cell RNA sequencing (scRNA-seq) technique begin a new era by allowing the observation of gene expression at the single cell level. However, there is also a large amount of technical and biological noise. Because of the
Externí odkaz:
https://doaj.org/article/eab0087e6a5748c9becf89601d4f5ace