Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Wulf Dirk Leuschner"'
Autor:
Hélène Bonnevaux, Stephane Guerif, Jana Albrecht, Erwan Jouannot, Thibaud De Gallier, Christian Beil, Christian Lange, Wulf Dirk Leuschner, Marion Schneider, Cendrine Lemoine, Anne Caron, Céline Amara, Cédric Barrière, Justine Siavellis, Valérie Bardet, Ernesto Luna, Pankaj Agrawal, Donald R. Drake, Ercole Rao, Peter Wonerow, Chantal Carrez, Véronique Blanc, Karl Hsu, Dmitri Wiederschain, Paula G. Fraenkel, Angéla Virone-Oddos
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
Novel therapies are needed for effective treatment of AML. In the relapsed setting, prognosis is very poor despite salvage treatment with chemotherapy. Evidence suggests that leukemic stem cells (LSCs) cause relapse. The cell surface receptor CD123 i
Externí odkaz:
https://doaj.org/article/1e989dd4f1bc4fabbee1419fc76e4439
Autor:
Norbert Furtmann, Marion Schneider, Nadja Spindler, Bjoern Steinmann, Ziyu Li, Ingo Focken, Joachim Meyer, Dilyana Dimova, Katja Kroll, Wulf Dirk Leuschner, Audrey Debeaumont, Magali Mathieu, Christian Lange, Werner Dittrich, Jochen Kruip, Thorsten Schmidt, Joerg Birkenfeld
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
Next-generation multi-specific antibody therapeutics (MSATs) are engineered to combine several functional activities into one molecule to provide higher efficacy compared to conventional, mono-specific antibody therapeutics. However, highly engineere
Externí odkaz:
https://doaj.org/article/98e82558dbcc41848215d30e62e1cd5e
Autor:
Christof Schindler, Christine Faust, Hanno Sjuts, Christian Lange, Jennifer Kühn, Werner Dittrich, Wulf Dirk Leuschner, Werner Schiebler, Joachim Hofmann, Ercole Rao, Thomas Langer
Publikováno v:
Protein Engineering, Design and Selection. 35
The field of therapeutic antibodies and, especially bi- or multispecific antibodies, is growing rapidly. Especially for treating cancers, multispecific antibodies are very promising, as there are multiple pathways involved and multispecific antibodie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::795f90423eb72ef734dd79403b0a33c6
https://doi.org/10.1093/protein/gzac014
https://doi.org/10.1093/protein/gzac014
Autor:
Audrey Debeaumont, Joachim Meyer, Wulf Dirk Leuschner, Jochen Kruip, Joerg Birkenfeld, Nadja Spindler, Norbert Furtmann, Katja Kroll, Ingo Focken, Bjoern Steinmann, Magali Mathieu, Werner Dittrich, Christian M. Lange, Dilyana Dimova, Ziyu Li, Thorsten Schmidt, M. Schneider
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Next-generation multi-specific antibody therapeutics (MSATs) are engineered to combine several functional activities into one molecule to provide higher efficacy compared to conventional, mono-specific antibody therapeutics. However, highly engineere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb39be2d54ff87cd04ff0fa33366b6ed
https://doi.org/10.1080/19420862.2021.1955433
https://doi.org/10.1080/19420862.2021.1955433
Autor:
Zachary Mankoff, Ronnie Wei, Dennis R. Burton, Krisha McKee, Dana M. Lord, Richard A. Koup, Christian Lange, Wulf Dirk Leuschner, Keyun Wang, Mario Roederer, Stephen D. Schmidt, Tongqing Zhou, Dan H. Barouch, Rebecca Sendak, Lawrence J. Tartaglia, Sijy O'Dell, Zhi Yong Yang, Misook Choe, Robert T. Bailer, Lan Wu, John R. Mascola, Mangaiarkarasi Asokan, Young Do Kwon, Amarendra Pegu, Ercole Rao, Ling Xu, Mark Connors, Peter D. Kwong, Jochen Kruip, Xuejun Chen, John-Paul Todd, Gejing Deng, Mark K. Louder, Gary J. Nabel, Nicole A. Doria-Rose, Christian Beil, Jochen Beninga
Publikováno v:
Science. 358:85-90
A triple threat for HIV The HIV virus continually evolves tricks to evade elimination by the host. Prevention and a cure will likely rely on broadly neutralizing antibodies that can recognize and conquer multiple viral strains or subtypes. Xu et al.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2172c5bb6377f321101fd31b8b9bf76d
https://doi.org/10.1126/science.aan8630
https://doi.org/10.1126/science.aan8630
Autor:
Justine Siavellis, Stephane Guerif, Agnès Vergezac, Ernesto Luna, Laurent Bassinet, Peter Wonerow, Ercole Rao, Corina Oprea, Karl Hsu, Anne Caron, Wulf Dirk Leuschner, Donald Drake, Chantal Carrez, Paula G. Fraenkel, Erwan Jouannot, Dmitri Wiederschain, Veronique Blanc, Cedric Barriere, Jana Albrecht, Hélène Bonnevaux, Christian Beil, Christian M. Lange, Valérie Bardet, Céline Amara
Publikováno v:
Cancer Research. 78:1785-1785
Acute myeloid leukemia (AML) is characterized by the accumulation of abnormal blast cells in the bone marrow and blood. While high intensity chemotherapy and allogeneic stem cell transplantation cure a subset of patients with AML, many patients are i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f031bf0679db6845f3db9b21197535e1
https://doi.org/10.1158/1538-7445.am2018-1785
https://doi.org/10.1158/1538-7445.am2018-1785
Autor:
Wulf Dirk Leuschner, Werner Hoch
Publikováno v:
Journal of Biological Chemistry. 274:16907-16916
Glutamate receptors (GluR) are oligomeric protein complexes formed by the assembly of four or perhaps five subunits. The rules that govern the selectivity of this process are not well understood. Here, we expressed combinations of subunits from two r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bebdba78bdd80f0fc544798cca066649
https://doi.org/10.1074/jbc.274.24.16907
https://doi.org/10.1074/jbc.274.24.16907