Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Wulf, Blankenfeldt"'
Autor:
Maria Braun-Cornejo, Camilla Ornago, Vidhisha Sonawane, Jörg Haupenthal, Andreas M. Kany, Eleonora Diamanti, Gwenaëlle Jézéquel, Norbert Reiling, Wulf Blankenfeldt, Peter Maas, Anna K. H. Hirsch
Publikováno v:
ACS Omega, Vol 9, Iss 36, Pp 38160-38168 (2024)
Externí odkaz:
https://doaj.org/article/e56a9b11024441f8a4f2917fc13a5392
Autor:
Fabian Piskol, Peer Lukat, Laurin Kaufhold, Alexander Heger, Wulf Blankenfeldt, Dieter Jahn, Jürgen Moser
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
Acinetobacter baumannii is an opportunistic human pathogen which can use host-derived L-carnitine as sole carbon and energy source. Recently, an L-carnitine transporter (Aci1347) and a specific monooxygense (CntA/CntB) for the intracellular cleavage
Externí odkaz:
https://doaj.org/article/24723026964341408995963a19b85573
Autor:
Chengzhang Fu, Yunkun Liu, Christine Walt, Sari Rasheed, Chantal D. Bader, Peer Lukat, Markus Neuber, F. P. Jake Haeckl, Wulf Blankenfeldt, Olga V. Kalinina, Rolf Müller
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract DNA polymerase III sliding clamp (DnaN) was recently validated as a new anti-tuberculosis target employing griselimycins. Three (2 S,4 R)−4-methylproline moieties of methylgriselimycin play significant roles in target binding and metabolic
Externí odkaz:
https://doaj.org/article/7e4cc23e8e7b46028e890b8dfe93715d
Autor:
Sarah Truthe, Tilman E. Klassert, Stefan Schmelz, Danny Jonigk, Wulf Blankenfeldt, Hortense Slevogt
Publikováno v:
Journal of Innate Immunity, Vol 16, Iss 1, Pp 105-132 (2024)
Background: Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is known as a major receptor for oxidized low-density lipoproteins (oxLDL) and plays a significant role in the genesis of atherosclerosis. Recent research has shown its invol
Externí odkaz:
https://doaj.org/article/d6ded191b0eb439486d19cea53a61c52
Autor:
Toni Mingers, Stefan Barthels, Violetta Mass, José Manuel Borrero-de Acuña, Rebekka Biedendieck, Ana Cooke, Tamara A. Dailey, Svetlana Gerdes, Wulf Blankenfeldt, Harry A. Dailey, Martin J. Warren, Martina Jahn, Dieter Jahn
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
Nature utilizes three distinct pathways to synthesize the essential enzyme cofactor heme. The coproporphyrin III-dependent pathway, predominantly present in Bacillaceae, employs an oxygen-dependent coproporphyrinogen III oxidase (CgoX) that converts
Externí odkaz:
https://doaj.org/article/c08797d53e68449fa3988cd244d0c552
Autor:
Fangfang Chen, Israfil Yalcin, Mingming Zhao, Chutao Chen, Wulf Blankenfeldt, Frank Pessler, Konrad Büssow
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract cis-Aconitate decarboxylase (ACOD1, IRG1) converts cis-aconitate to the immunomodulatory and antibacterial metabolite itaconate. Although the active site residues of human and mouse ACOD1 are identical, the mouse enzyme is about fivefold mor
Externí odkaz:
https://doaj.org/article/c50406fb587145cd92e795a1e7835eac
Autor:
Marco Kirchenwitz, Jessica Halfen, Kristin von Peinen, Silvia Prettin, Jana Kollasser, Susanne zur Lage, Wulf Blankenfeldt, Cord Brakebusch, Klemens Rottner, Anika Steffen, Theresia E.B. Stradal
Publikováno v:
European Journal of Cell Biology, Vol 102, Iss 4, Pp 151358- (2023)
Salmonella enterica serovar Typhimurium manipulates cellular Rho GTPases for host cell invasion by effector protein translocation via the Type III Secretion System (T3SS). The two Guanine nucleotide exchange (GEF) mimicking factors SopE and –E2 and
Externí odkaz:
https://doaj.org/article/f562a49199fb41ca8606daa57c42f1ee
Autor:
Sebastian Roman Borgert, Steffi Henke, Florian Witzgall, Stefan Schmelz, Susanne zur Lage, Sven-Kevin Hotop, Steffi Stephen, Dennis Lübken, Jonas Krüger, Nicolas Oswaldo Gomez, Marco van Ham, Lothar Jänsch, Markus Kalesse, Andreas Pich, Mark Brönstrup, Susanne Häussler, Wulf Blankenfeldt
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Abstract Pseudomonas aeruginosa is a major cause of nosocomial infections and also leads to severe exacerbations in cystic fibrosis or chronic obstructive pulmonary disease. Three intertwined quorum sensing systems control virulence of P. aeruginosa,
Externí odkaz:
https://doaj.org/article/0f0b91a8c4f34e998f22e33116f8f4b6
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Box C/D ribonucleoprotein complexes are RNA-guided methyltransferases that methylate the ribose 2’-OH of RNA. The central ‘guide RNA’ has box C and D motifs at its ends, which are crucial for activity. Archaeal guide RNAs have a second
Externí odkaz:
https://doaj.org/article/6b06d43f8c7b44b0bfbeb0e72c36370a
Autor:
Christian Schütz, Duy‐Khiet Ho, Mostafa Mohamed Hamed, Ahmed Saad Abdelsamie, Teresa Röhrig, Christian Herr, Andreas Martin Kany, Katharina Rox, Stefan Schmelz, Lorenz Siebenbürger, Marius Wirth, Carsten Börger, Samir Yahiaoui, Robert Bals, Andrea Scrima, Wulf Blankenfeldt, Justus Constantin Horstmann, Rebekka Christmann, Xabier Murgia, Marcus Koch, Aylin Berwanger, Brigitta Loretz, Anna Katharina Herta Hirsch, Rolf Wolfgang Hartmann, Claus‐Michael Lehr, Martin Empting
Publikováno v:
Advanced Science, Vol 8, Iss 12, Pp n/a-n/a (2021)
Abstract Pseudomonas aeruginosa (PA) infections can be notoriously difficult to treat and are often accompanied by the development of antimicrobial resistance (AMR). Quorum sensing inhibitors (QSI) acting on PqsR (MvfR) – a crucial transcriptional
Externí odkaz:
https://doaj.org/article/e48e16d2f7b2409bac151ac65a104396