Zobrazeno 1 - 10
of 201
pro vyhledávání: '"Wujun Chen"'
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-41 (2024)
Abstract Proteolysis-targeting chimeras (PROTACs) technology has garnered significant attention over the last 10 years, representing a burgeoning therapeutic approach with the potential to address pathogenic proteins that have historically posed chal
Externí odkaz:
https://doaj.org/article/73df80a5fdc748c4be93831ff8bf6fb9
Autor:
Wujun Chen, Xiaolin Wu, Jianxia Hu, Xiaolei Liu, Zhu Guo, Jianfeng Wu, Yingchun Shao, Minglu Hao, Shuangshuang Zhang, Weichao Hu, Yanhong Wang, Miao Zhang, Meng Zhu, Chao Wang, Yudong Wu, Jie Wang, Dongming Xing
Publikováno v:
Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-21 (2024)
Abstract Atherosclerosis is one of the leading causes of death worldwide. miR-26 is a potential biomarker of atherosclerosis. Standardized diagnostic tests for miR-26 (MIR26-DX) have been developed, but the fastest progress has been in predicting the
Externí odkaz:
https://doaj.org/article/7b161dbc163f4e7a9a4ed16ae9ac1163
Autor:
Jie Wang, Zongying Zhang, Rongxiang Liang, Wujun Chen, Qian Li, Jiazhen Xu, Hongmei Zhao, Dongming Xing
Publikováno v:
Materials Today Bio, Vol 26, Iss , Pp 101068- (2024)
Lymph nodes (LNs) occupy a critical position in initiating and augmenting immune responses, both spatially and functionally. In cancer immunotherapy, tumor-specific vaccines are blooming as a powerful tool to suppress the growth of existing tumors, a
Externí odkaz:
https://doaj.org/article/3ef17f9de0294eb28e8bc69462a584a2
Publikováno v:
Genes and Diseases, Vol 10, Iss 6, Pp 2457-2469 (2023)
Atherosclerosis is one of the leading causes of disease and death worldwide. The identification of new therapeutic targets and agents is critical. JAZF1 is expressed in many tissues and is found at particularly high levels in adipose tissue (AT). JAZ
Externí odkaz:
https://doaj.org/article/877d9f42344646d3b72a8f14efc78c60
Autor:
Wujun Chen, Yihui Liu, Ling Li, Bing Liang, Shuai Wang, Xiaodan Xu, Dongming Xing, Xiaolin Wu
Publikováno v:
Non-coding RNA Research, Vol 8, Iss 3, Pp 315-325 (2023)
Atherosclerosis is a significant risk factor for coronary heart disease (CHD) and myocardial infarction (MI). Atherosclerosis develops during foam cell generation, which is caused by an imbalance in cholesterol uptake, esterification, and efflux. LOX
Externí odkaz:
https://doaj.org/article/1d51795b7c5042b4a31b4b30cdf351a7
Publikováno v:
BMC Veterinary Research, Vol 19, Iss 1, Pp 1-9 (2023)
Abstract Background Ilicis chinensis folium extract (ICFE) is a powder extracted and processed with Ilex chinensis Sims (ICS) which has numerous bioactivities and is conventionally used in traditional Chinese medicine. Nonetheless, there has been no
Externí odkaz:
https://doaj.org/article/86196d86cfcb4ccd87bf0c0ff6fd20e6
Autor:
Xinlin Liu, Junwen Deng, Renshuai Zhang, Jiyao Xing, Yudong Wu, Wujun Chen, Bing Liang, Dongming Xing, Jiazhen Xu, Miao Zhang
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Despite the emergence of molecular targeted therapy and immune checkpoint inhibitors as standard first-line treatments for non-small cell lung cancer (NSCLC), their efficacy in some patients is limited by intrinsic and acquired resistance. Antibody-d
Externí odkaz:
https://doaj.org/article/8c72c3e2cee643778f44cc8226fecdb7
Autor:
Yingchun Shao, Jiazhen Xu, Bing Liang, Shuangshuang Zhang, Wujun Chen, Yanhong Wang, Dongming Xing
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 167, Iss , Pp 115589- (2023)
Cerebellar degeneration-related protein 1 antisense RNA (CDR1as), also known as ciRS-7, is a circular natural antisense transcript of CDR1. It is a widely studied and powerful representative of circular RNAs. Based on its widely reported role in canc
Externí odkaz:
https://doaj.org/article/4aa4e9ae93c945cca4064816eb7514bc
Publikováno v:
Arabian Journal of Chemistry, Vol 16, Iss 10, Pp 105146- (2023)
Some novel 4-aryl-9H-carbazoles were designed as potential tubulin polymerization inhibitors through structural optimization and bioisosteric strategy. These compounds showed effective antiproliferative activities against a diverse set of cancer cell
Externí odkaz:
https://doaj.org/article/fef20283db844083b3465c663f87a13c
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1694-1703 (2022)
BRDs proteins that recognise chromatin acetylation regulate gene expression, are epigenetic readers and master transcription coactivators. BRDs proteins are now emerging as targets for new therapeutic development. Blocking the function of any of BRDs
Externí odkaz:
https://doaj.org/article/972d442f7e2144a59fa7e46ce7436fc6