Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Wuhong Pei"'
Suppressing STAT3 activity protects the endothelial barrier from VEGF-mediated vascular permeability
Autor:
Li Wang, Matteo Astone, Sk. Kayum Alam, Zhu Zhu, Wuhong Pei, David A. Frank, Shawn M. Burgess, Luke H. Hoeppner
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 11 (2021)
Vascular permeability triggered by inflammation or ischemia promotes edema, exacerbates disease progression and impairs tissue recovery. Vascular endothelial growth factor (VEGF) is a potent inducer of vascular permeability. VEGF plays an integral ro
Externí odkaz:
https://doaj.org/article/e0dc8cc722bd42cda353c17a0dde9094
Autor:
Wei-Chia Tseng, Hannah E. Loeb, Wuhong Pei, Chon-Hwa Tsai-Morris, Lisha Xu, Celine V. Cluzeau, Christopher A. Wassif, Benjamin Feldman, Shawn M. Burgess, William J. Pavan, Forbes D. Porter
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 9 (2018)
Niemann-Pick disease type C1 (NPC1) is a rare autosomal recessive lysosomal storage disease primarily caused by mutations in NPC1. NPC1 is characterized by abnormal accumulation of unesterified cholesterol and glycolipids in late endosomes and lysoso
Externí odkaz:
https://doaj.org/article/56fcfa5c85bd4a1eb7330a4d2e257a35
Autor:
Arife Unal Eroglu, Timothy S. Mulligan, Liyun Zhang, David T. White, Sumitra Sengupta, Cathy Nie, Noela Y. Lu, Jiang Qian, Lisha Xu, Wuhong Pei, Shawn M. Burgess, Meera T. Saxena, Jeff S. Mumm
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 6 (2018)
Thousands of genes have been implicated in retinal regeneration, but only a few have been shown to impact the regenerative capacity of Müller glia—an adult retinal stem cell with untapped therapeutic potential. Similarly, among nearly 300 genetic
Externí odkaz:
https://doaj.org/article/26f4e85cc8724161b9abfd475abe72c6
Autor:
Wuhong Pei, Sunny C. Huang, Lisha Xu, Kade Pettie, María Laura Ceci, Mario Sánchez, Miguel L. Allende, Shawn M. Burgess
Publikováno v:
Cell Regeneration, Vol 5, Iss 1 (2016)
Background: We are using genetics to identify genes specifically involved in hearing regeneration. In a large-scale genetic screening, we identified mgat5a, a gene in the N-glycosylation biosynthesis pathway whose activity negatively impacts hair cel
Externí odkaz:
https://doaj.org/article/05dcd4fc8f2c4b448f12c912770d1eeb
Autor:
Sarthak Gupta, Amanda K. Ombrello, Emily Rominger, Megan Trick, Karyl S. Barron, Ryan S. Laird, Sinisa Savic, Shuichiro Nakabo, Daniela Ospina Cardona, Ivona Aksentijevich, Carmelo Carmona-Rivera, Gustaf Wigerblad, Mariana J. Kaplan, Emma M. Groarke, Laura W. Dillon, Chyi-Chia Richard Lee, Kalpana Manthiram, Kristina V. Wells, Nicholas Balanda, Zhijie Wu, Helen J. Lachmann, Daniel L. Kastner, Fernanda Gutierrez-Rodrigues, Achim Werner, Michele Nehrebecky, Lisha Xu, Alina Dulau-Florea, Wanxia L. Tsai, Bhavisha A Patel, Stefania Dell'Orso, Weixin Wang, Anthony J. Asmar, Danica Novacic, Katherine R. Calvo, David B. Beck, Robert A. Colbert, Massimo Gadina, William A. Gahl, Wendy Goodspeed, Natalie Deuitch, Dorota Rowczenio, Peter C. Grayson, Daron L. Ross, Sofia Rosenzweig, Anne Jones, Christopher S. Hourigan, James C. Mullikin, Stephen R. Brooks, Jason C. Collins, Wuhong Pei, May Christine V. Malicdan, Neal S. Young, Shawn M. Burgess, Keith A. Sikora, Mones Abu-Asab, Kyle Retterer, Patrycja Hoffmann, Hirotsugu Oda, Marcela A. Ferrada, Zuoming Deng, Benjamin D. Solomon, Jae Jin Chae
Publikováno v:
New England Journal of Medicine. 383:2628-2638
Background Adult-onset inflammatory syndromes often manifest with overlapping clinical features. Variants in ubiquitin-related genes, previously implicated in autoinflammatory disease, may...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99ad8cf39fc35fb40359e43ad0eff90c
https://doi.org/10.1056/nejmoa2026834
https://doi.org/10.1056/nejmoa2026834
Autor:
Stephen Wincovitch, Shawn M. Burgess, Nisc Comparative Sequencing Program, Lisha Xu, Kade P Pettie, Claire Slevin, Zelin Chen, Wuhong Pei
Publikováno v:
npj Regenerative Medicine, Vol 5, Iss 1, Pp 1-14 (2020)
NPJ Regenerative Medicine
NPJ Regenerative Medicine
Spinal muscular atrophy (SMA) is the most common genetic disease in children. SMA is generally caused by mutations in the gene SMN1. The survival of motor neurons (SMN) complex consists of SMN1, Gemins (2–8), and Strap/Unrip. We previously demonstr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83763848a741e4b1ea39aecc8ecac3fa
http://link.springer.com/article/10.1038/s41536-020-0089-0
http://link.springer.com/article/10.1038/s41536-020-0089-0
Suppressing STAT3 activity protects the endothelial barrier from VEGF-mediated vascular permeability
Autor:
Shawn M. Burgess, Luke H. Hoeppner, Matteo Astone, Wuhong Pei, Zhu Zhu, David A. Frank, Sk Kayum Alam, Li Wang
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 11 (2021)
bioRxiv
article-version (status) pre
article-version (number) 1
Disease Models & Mechanisms
article-version (VoR) Version of Record
bioRxiv
article-version (status) pre
article-version (number) 1
Disease Models & Mechanisms
article-version (VoR) Version of Record
Vascular permeability triggered by inflammation or ischemia promotes edema, exacerbates disease progression and impairs tissue recovery. Vascular endothelial growth factor (VEGF) is a potent inducer of vascular permeability. VEGF plays an integral ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b97439efa205c07fb3cfce006c53756
https://doi.org/10.1242/dmm.049029
https://doi.org/10.1242/dmm.049029
Autor:
Rachel Weinstein, Kevin Bishop, Elizabeth Broadbridge, Kai Yu, Blake Carrington, Abdel Elkahloun, Tao Zhen, Wuhong Pei, Shawn M. Burgess, Paul Liu, Erica Bresciani, Raman Sood
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 18; Pages: 10668
ZRSR2 (zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2) is an essential splicing factor involved in 3′ splice-site recognition as a component of both the major and minor spliceosomes that mediate the splicing of U2-type (major)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cdc704ebb1d15186ea15d8415f9967b
https://doi.org/10.3390/ijms231810668
https://doi.org/10.3390/ijms231810668
Autor:
John McElderry, Zelin Chen, Ramanagouda Ramanagoudr-Bhojappa, Blake Carrington, Shawn M. Burgess, Raman Sood, Erika Kim, Pengfei Liu, Kevin Bishop, Anupam Prakash, Wuhong Pei
Publikováno v:
Hum Mol Genet
DHX15, a DEAH box containing RNA helicase, is a splicing factor required for the last step of splicing. Recent studies identified a recurrent mutational hotspot, R222G, in DHX15 in ∼ 6% of acute myeloid leukemia (AML) patients that carry the fusion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed3c476363bd6de54b7a463ea9f206f3
https://doi.org/10.1093/hmg/ddz261
https://doi.org/10.1093/hmg/ddz261
Autor:
David B, Beck, Marcela A, Ferrada, Keith A, Sikora, Amanda K, Ombrello, Jason C, Collins, Wuhong, Pei, Nicholas, Balanda, Daron L, Ross, Daniela, Ospina Cardona, Zhijie, Wu, Bhavisha, Patel, Kalpana, Manthiram, Emma M, Groarke, Fernanda, Gutierrez-Rodrigues, Patrycja, Hoffmann, Sofia, Rosenzweig, Shuichiro, Nakabo, Laura W, Dillon, Christopher S, Hourigan, Wanxia L, Tsai, Sarthak, Gupta, Carmelo, Carmona-Rivera, Anthony J, Asmar, Lisha, Xu, Hirotsugu, Oda, Wendy, Goodspeed, Karyl S, Barron, Michele, Nehrebecky, Anne, Jones, Ryan S, Laird, Natalie, Deuitch, Dorota, Rowczenio, Emily, Rominger, Kristina V, Wells, Chyi-Chia R, Lee, Weixin, Wang, Megan, Trick, James, Mullikin, Gustaf, Wigerblad, Stephen, Brooks, Stefania, Dell'Orso, Zuoming, Deng, Jae J, Chae, Alina, Dulau-Florea, May C V, Malicdan, Danica, Novacic, Robert A, Colbert, Mariana J, Kaplan, Massimo, Gadina, Sinisa, Savic, Helen J, Lachmann, Mones, Abu-Asab, Benjamin D, Solomon, Kyle, Retterer, William A, Gahl, Shawn M, Burgess, Ivona, Aksentijevich, Neal S, Young, Katherine R, Calvo, Achim, Werner, Daniel L, Kastner, Peter C, Grayson
Publikováno v:
Arthritis Rheumatol
Adult-onset inflammatory syndromes often manifest with overlapping clinical features. Variants in ubiquitin-related genes, previously implicated in autoinflammatory disease, may define new disorders.We analyzed peripheral-blood exome sequence data in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8619cd7f680f820c748afb4ee52d1640
https://pubmed.ncbi.nlm.nih.gov/34463053
https://pubmed.ncbi.nlm.nih.gov/34463053