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Akademický článek

Ginseng-derived nanoparticles alter macrophage polarization to inhibit melanoma growth

Autor: Meng Cao, Huaijiang Yan, Xuan Han, Ling Weng, Qin Wei, Xiaoyan Sun, Wuguang Lu, Qingyun Wei, Juan Ye, Xueting Cai, Chunping Hu, Xiaoyang Yin, Peng Cao

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-18 (2019)

Abstract Background It is unclear whether plant-derived extracellular vesicles (EVs) can mediate interspecies communication with mammalian cells. Tumor-associated macrophages (TAMs) display a continuum of different polarization states between tumoric

Externí odkaz: https://doaj.org/article/ece6e8e0dbbd4dd496b6bcdd559a8d35

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Akademický článek

Over-expression of Nav1.6 channels is associated with lymph node metastases in colorectal cancer

Autor: Shuiquan Lin, Yangbo Lv, Jianguang Xu, Xinglong Mao, Zhenhong Chen, Wuguang Lu

Publikováno v: World Journal of Surgical Oncology, Vol 17, Iss 1, Pp 1-10 (2019)

Abstract Background and objectives Lymph node metastasis is a key factor in predicting and determining the prognosis of patients with colorectal cancer (CRC). Sodium channels are highly expressed in a variety of tumors and are closely related to tumo

Externí odkaz: https://doaj.org/article/2e9943ba4f944414bc6db55dbec7b64d

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Akademický článek

Herbal Medicine AC591 Prevents Oxaliplatin-Induced Peripheral Neuropathy in Animal Model and Cancer Patients

Autor: Xiaolan Cheng, Jiege Huo, Dawei Wang, Xueting Cai, Xiaoyan Sun, Wuguang Lu, Yang Yang, Chunping Hu, Xiaoning Wang, Peng Cao

Publikováno v: Frontiers in Pharmacology, Vol 8 (2017)

Oxaliplatin is clinically compelling because of severe peripheral neuropathy. The side effect can result in dosage reductions or even cessation of chemotherapy, and no effective treatments are available. AC591 is a standardized extract of Huangqi Gui

Externí odkaz: https://doaj.org/article/56efcdcb56cb42f3ad0b640c633761bd

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Akademický článek

A Rationally Designed TNF-α Epitope-Scaffold Immunogen Induces Sustained Antibody Response and Alleviates Collagen-Induced Arthritis in Mice.

Autor: Li Zhang, Jin Wang, Aizhang Xu, Conghao Zhong, Wuguang Lu, Li Deng, Rongxiu Li

Publikováno v: PLoS ONE, Vol 11, Iss 9, p e0163080 (2016)

The TNF-α biological inhibitors have significantly improved the clinical outcomes of many autoimmune diseases, in particular rheumatoid arthritis. However, the practical uses are limited due to high costs and the risk of anti-drug antibody responses

Externí odkaz: https://doaj.org/article/16077632138048ee956fe8355a864073

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Akademický článek

Correction: Digitoflavone Inhibits IκBα Kinase and Enhances Apoptosis Induced by TNFα through Downregulation of Expression of Nuclear Factor κB-Regulated Gene Products in Human Pancreatic Cancer Cells.

Autor: Xueting Cai, Wuguang Lu, Yang Yang, Jie Yang, Juan Ye, Zhenhua Gu, Chunping Hu, Xiaoning Wang, Peng Cao

Publikováno v: PLoS ONE, Vol 8, Iss 10 (2013)

Externí odkaz: https://doaj.org/article/c354daaabda949d18d57b264c3a56e1e

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Akademický článek

Antinociceptive effects of analgesic-antitumor peptide (AGAP), a neurotoxin from the scorpion Buthus martensii Karsch, on formalin-induced inflammatory pain through a mitogen-activated protein kinases-dependent mechanism in mice.

Autor: Qinghong Mao, Jiaping Ruan, Xueting Cai, Wuguang Lu, Juan Ye, Jie Yang, Yang Yang, Xiaoyan Sun, Junli Cao, Peng Cao

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e78239 (2013)

In the present study, we investigated the anti-nociceptive effect and the underlying mechanism of the analgesic-antitumor peptide (AGAP), a neurotoxin from the scorpion Buthus martensii Karsch. AGAP in doses of 0.2, 1 and 5 µg was injected intraplan

Externí odkaz: https://doaj.org/article/89f55d3b740d47d2bca6dcb2b4daf983

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Akademický článek

Digitoflavone inhibits IκBα kinase and enhances apoptosis induced by TNFα through downregulation of expression of nuclear factor κB-regulated gene products in human pancreatic cancer cells.

Autor: Xueting Cai, Wuguang Lu, Yang Yang, Jie Yang, Juan Ye, Zhenhua Gu, Chunping Hu, Xiaoning Wang, Peng Cao

Publikováno v: PLoS ONE, Vol 8, Iss 10, p e77126 (2013)

Tumor necrosis factor-α (TNFα) activates both cell death and cell survival pathways. The activation of survival pathway renders most cancer cells resistant to TNF-induced cytotoxicity. We found that pretreatment with digitoflavone, a plant flavonoi

Externí odkaz: https://doaj.org/article/493a3316c851466bb5d1810acf7f96d3

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